DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr20 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_612066.1	Gene:	dpr20 / 38101	FlyBaseID:	FBgn0035170	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	287	Identity:	55/287 - (19%)
Similarity:	101/287 - (35%)	Gaps:	106/287 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 EDVQRIGQATNLTVQAGSSIHLNCR-ISLLQDKTVSWVRHNTQDEG--------KD--------- 314
            ||. ||.....:.:|||:..:|.|| .:.....|:.|.|..||.||        ||
Human   121 EDT-RIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQ 184

  Fly   315 ---NGNALDL------------LTVGMHTYTGDKRYKMEFQYPNNWRLKI--TNVKKDDEAIYEC 362
               |...||:            :..|..|     ..:::..:|....|.|  ..|::.:..::.|
Human   185 LLINPTDLDIGRVFTCRSMNEAIPSGKET-----SIELDVHHPPTVTLSIEPQTVQEGERVVFTC 244

  Fly   363 QISTHPPRV----------------------------------------------IQINLHVNAP 381
            |.:.:|..:                                              ..:|:|. ||
Human   245 QATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHF-AP 308

  Fly   382 KVMIVDEVGDPLQEKYYEIDSTLQLSCV-VRNVAMTSSVVFWKHMDNILNYDVTRGG----VSVK 441
            ::::     || :....:|.|.:.|:|| |.|..:|   :.|...|:  |......|    .::.
Human   309 RIVV-----DP-KPTTTDIGSDVTLTCVWVGNPPLT---LTWTKKDS--NMGPRPPGSPPEAALS 362

  Fly   442 TELMEDGANSTLSIAKISKTDSGNYTC 468
            .:::.:  ::.|.:..:::.|:|.|||
Human   363 AQVLSN--SNQLLLKSVTQADAGTYTC 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr20	NP_612066.1	IG_like	278..365	CDD:214653	26/121 (21%)
		Ig	279..378	CDD:299845	28/179 (16%)
		Ig	400..471	CDD:299845	18/74 (24%)
		IG_like	402..480	CDD:214653	17/72 (24%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352
		Ig	25..116	CDD:299845
		Ig2_KIRREL3-like	138..219	CDD:143236	17/85 (20%)
		I-set	223..304	CDD:254352	6/80 (8%)
		Ig_2	227..305	CDD:290606	7/77 (9%)
		Ig_2	311..405	CDD:290606	20/90 (22%)
		IG_like	314..405	CDD:214653	19/82 (23%)
		Ig5_KIRREL3	407..504	CDD:143306
		IG_like	416..504	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810