DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr20 and SDK1

DIOPT Version :9

Sequence 1:NP_612066.1 Gene:dpr20 / 38101 FlyBaseID:FBgn0035170 Length:525 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:556 Identity:109/556 - (19%)
Similarity:195/556 - (35%) Gaps:153/556 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 KSTTDATKFSSSRGDLHLDCAVPNLIRL-----LLLIATIMGSGLVQAKTIYDSVNMIQSLDALV 74
            :..::.|.:||     .....:|:|.:|     ..::...||: |:|.|:......|...:|  .
Human   140 RDDSELTTYSS-----EYKYIIPSLQKLDAGFYRCVVRNRMGA-LLQRKSEVQVAYMGSFMD--T 196

  Fly    75 EPRETTK----VPLQTTPATPPTAHAHIHNQVSTLRSSYEDSDDGVDGDYVIPESQTSTVAILDQ 135
            :.|:|..    ..|...|.|     ::...||:..|          :|..:||.::   :||   
Human   197 DQRKTVSQGRAAILNLLPIT-----SYPRPQVTWFR----------EGHKIIPSNR---IAI--- 240

  Fly   136 DSSMKGQDMESLSLQAGSGTVSPKSSPDSSGHKKNASFQQIG-SQNVNALVPATVATT------- 192
              :::.|.:...:..:.:|....::..:.:|..|.:.|..:. :::|.  .|.|:|.|       
Human   241 --TLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVG--TPETMAPTIVVPPGN 301

  Fly   193 SSGLPSSSNASL--ATPTEPARNRSTGLVRNSAVKVDSKHP----LSKGQKTDAPMLNYIFD--- 248
            .|.:..||..:|  .....|..:.|....||........|.    |:....|.|....|:.:   
Human   302 RSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAAL 366

  Fly   249 ---TFSSANKHHHHDQRYGPHF--EDVQRIGQATNLTVQAGSSIHLNCRISLLQDKTVSWVRHNT 308
               .|..|...........|:|  |...||......||..|      |:...:...|:.|.:   
Human   367 PGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIG------CQAMGVPLPTLQWYK--- 422

  Fly   309 QDEGKDNGNALDLLTVGMHTYTGDKRYKMEFQYPNNWRLKITNVKKDDEAIYEC-------QIST 366
                       |.:::   :...:.|||:    ..:..|:|..::.:|..|::|       :|.|
Human   423 -----------DAISI---SRLQNPRYKV----LASGGLRIQKLRPEDSGIFQCFASNEGGEIQT 469

  Fly   367 HPPRVIQINLHVNAPKVMIVDEVGDPLQEKYYEIDSTLQ------LSCVVRNVAMTSSVVFWKHM 425
            |              ..:.|..:.....::  .:|:|:.      |.|.|...  ....:.||..
Human   470 H--------------TYLDVTNIAPVFTQR--PVDTTVTDGMTAILRCEVSGA--PKPAITWKRE 516

  Fly   426 DNILNYDVTRGGVSV-KTELMEDGANSTLSIAKISKTDSGNYTCSISEFQ------------NFT 477
            ::||    ..|.|.: :..|:|.|.   |.||.:...|:|||||..:..:            |.|
Human   517 NHIL----ASGSVRIPRFMLLESGG---LQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRT 574

  Fly   478 IVVH------ILNGESFAELH----HGGAVGWHSTW 503
            .:||      ::.|.: |.||    |...|.....|
Human   575 SIVHPPEDHVVIKGTT-ATLHCGATHDPRVSLRYVW 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr20NP_612066.1 IG_like 278..365 CDD:214653 15/93 (16%)
Ig 279..378 CDD:299845 18/105 (17%)
Ig 400..471 CDD:299845 23/77 (30%)
IG_like 402..480 CDD:214653 24/96 (25%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352 11/53 (21%)
Ig 122..176 CDD:143165 6/40 (15%)
Ig 219..265 CDD:299845 10/63 (16%)
IGc2 312..364 CDD:197706 10/51 (20%)
I-set 386..475 CDD:254352 23/129 (18%)
Ig 404..472 CDD:143165 17/108 (16%)
I-set 480..570 CDD:254352 23/100 (23%)
Ig 494..570 CDD:299845 21/84 (25%)
I-set 575..664 CDD:254352 9/36 (25%)
Ig 580..664 CDD:299845 7/31 (23%)
FN3 668..759 CDD:238020
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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