DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr20 and Dscaml1

DIOPT Version :9

Sequence 1:	NP_612066.1	Gene:	dpr20 / 38101	FlyBaseID:	FBgn0035170	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001074739.2	Gene:	Dscaml1 / 114873	MGIID:	2150309	Length:	2053	Species:	Mus musculus

Alignment Length:	359	Identity:	77/359 - (21%)
Similarity:	139/359 - (38%)	Gaps:	73/359 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 SMKGQDMESLSLQAGSGTVSPKSSPDSSGHKKNA-SFQQIGSQNVNALVPATVATTSSGLP---S 198
            |::|...|:|.:              ||..|.:: ::|...::.........:.....|.|   |
Mouse   362 SIRGLSNETLLI--------------SSAQKSHSGAYQCFATRKAQTAQDFAIIVLEDGTPRIVS 412

  Fly   199 SSNASLATPTE------PARNRS----TGLVRNSAVKVDSKHPLSKGQKTDAPMLNYIFDTFSSA 253
            |.:..:..|.|      .|:...    |..:.:..|..|..|..::...:|...::::..|
Mouse   413 SFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVRDGSHRTNQYTMSDGTTISHMNVT---- 473

  Fly   254 NKHHHHDQRYGPHFEDVQRIGQATNLTVQ-AGSSIHLNCRISLLQDKTVSWVRHNTQDEGKDNGN 317
                      ||...|    |.....|.: :..|.....||::....::..:|:.|...|:|  .
Mouse   474 ----------GPQIRD----GGVYRCTARNSVGSAEYQARINVRGPPSIRAMRNITAVAGRD--T 522

  Fly   318 ALDLLTVGMHTYTGDKRYKMEFQYPNNWR--------LKITNVKKD-DEAIYECQISTHPPRVIQ 373
            .::...:| :.|...|.||.....|:|.|        ||:|:|:|. ||..|.|.:...|...|.
Mouse   523 LINCRVIG-YPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSIS 586

  Fly   374 INLHVNAPKVMIVDEVGDPLQEKYYEIDSTLQLSCVVRNVAMTSSVVFWKHMDNILNYDVTRGGV 438
            .::||    .:.|..:..|.:.....|...|.:.|||.:..|...:. |:....::   ::..||
Mouse   587 QSVHV----AVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRIT-WRKDGQVI---ISGSGV 643

  Fly   439 SVKT-ELMEDGANSTLSIAKISKTDSGNYTCSIS 471
            :::: |.|     |:|.|:.:|...:|||||..|
Mouse   644 TIESKEFM-----SSLQISSVSLKHNGNYTCIAS 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr20	NP_612066.1	IG_like	278..365	CDD:214653	25/96 (26%)
		Ig	279..378	CDD:299845	27/108 (25%)
		Ig	400..471	CDD:299845	20/71 (28%)
		IG_like	402..480	CDD:214653	20/71 (28%)
Dscaml1	NP_001074739.2	IGc2	43..110	CDD:197706
		Ig	125..218	CDD:353325
		I-set	226..311	CDD:336764
		Ig_3	317..389	CDD:339005	8/40 (20%)
		Ig	408..498	CDD:353325	18/107 (17%)
		IGc2	519..577	CDD:197706	19/60 (32%)
		Ig	615..681	CDD:319273	19/67 (28%)
		Ig_DSCAM	707..785	CDD:143211
		Ig	803..891	CDD:353325
		FN3	887..981	CDD:238020
		FN3	988..1085	CDD:238020
		FN3	1093..1186	CDD:238020
		FN3	1191..1282	CDD:238020
		Ig	1307..1377	CDD:319273
		FN3	1384..1474	CDD:238020
		FN3	1488..1560	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1716..1741
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1773..1803
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1840..1862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1974..2053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810