DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr20 and dscam

DIOPT Version :9

Sequence 1:	NP_612066.1	Gene:	dpr20 / 38101	FlyBaseID:	FBgn0035170	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_031751619.1	Gene:	dscam / 100216449	XenbaseID:	XB-GENE-921689	Length:	2039	Species:	Xenopus tropicalis

Alignment Length:	490	Identity:	93/490 - (18%)
Similarity:	158/490 - (32%)	Gaps:	181/490 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GSGLVQAKTIYDSVNMIQSLDALVEPRETTKVPLQTTPATPPTAHAHIHNQVSTLRSSYEDSDD- 114
            ||.:.:....|.:..:|.||        ..|.||:.. .:|....:.:.:|:| |..|...:||
Frog   289 GSYVCEVWNNYGNAEVIGSL--------YVKQPLKVN-ISPRKVKSSVGSQIS-LACSVTGTDDP 343

  Fly   115 --------------------GVDGDYVI----PESQTSTVAILDQDSSMKGQDMESLSLQAGS-- 153
                                ||:.:.:|    .:|.:.......:...|..||...:.|:.|:
Frog   344 DLSWYRNGEIINAGNNVRITGVNRETLIMDGMAKSDSGAYQCFVRREKMSAQDYVQVVLEDGTPK 408

  Fly   154 -------GTVSP----------KSSP--------DSSGHKKNASFQQIGSQNVNALVPATVATTS 193
                   ..|||          |.:|        |.....||      |:..::.|:     |:.
Frog   409 IISAFSEKVVSPGEPVSLMCNVKGTPLPTITWTLDDDPIIKN------GNHRISQLI-----TSE 462

  Fly   194 SGLPSSSNASLATPTEP--------ARNRSTGLVRNSAVKVDSKHPLSKGQKTDAPMLNYIFDTF 250
            ..:.|..|   .|.|:.        ..|.|.|:|...| :::.:.|.|
Frog   463 GNVVSYLN---ITNTQVRDGGVYRCTANNSAGVVLYQA-RINVRGPAS----------------- 506

  Fly   251 SSANKHHHHDQRYGPHFEDVQRIGQATNLTVQAGSSIHLNCRISLLQDKTVSWVRHNTQDEGKDN 315
                                  |....|:|..||...:::||:......::.|.:         |
Frog   507 ----------------------IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK---------N 540

  Fly   316 GNALDLLTVGMHTYTGDKRYKMEFQYPNNWRLKITNVKKD-DEAIYECQISTHPPRVIQINLHVN 379
            .|.|..             ...:..:.||..||:::|:|| ||..|.|.:...|......::||.
Frog   541 SNLLPF-------------NHRQVAFENNGTLKLSDVQKDVDEGEYMCNVLVQPQLSTSQSVHVT 592

  Fly   380 APKVMIVDEVGDPLQEKYYEIDSTLQLSCVVRNVAMTSSVVFWKH-----------MDNILNYDV 433
            ..    |.....|.:.:.:.|...:.:.|||.:..:..::.:.|.           :|||   |.
Frog   593 VK----VPPFIQPFESQRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNI---DF 650

  Fly   434 TRGGVSVKTELMEDGANSTLSIAKISKTDSGNYTC 468
            |                |:|.|:.:|...:|||||
Frog   651 T----------------SSLRISNLSLMHNGNYTC 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr20	NP_612066.1	IG_like	278..365	CDD:214653	21/87 (24%)
		Ig	279..378	CDD:299845	21/99 (21%)
		Ig	400..471	CDD:299845	19/80 (24%)
		IG_like	402..480	CDD:214653	18/78 (23%)
dscam	XP_031751619.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	124..217	CDD:416386
		Ig strand A'	127..136	CDD:409353
		Ig strand B	140..147	CDD:409353
		Ig strand C	157..162	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand D	172..176	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	193..201	CDD:409353
		Ig strand G	205..217	CDD:409353
		Ig strand A	225..228	CDD:409353
		Ig strand A'	234..237	CDD:409353
		IG_like	236..310	CDD:214653	6/28 (21%)
		Ig strand B	242..249	CDD:409353
		Ig strand C	255..260	CDD:409353
		Ig strand C'	262..264	CDD:409353
		Ig strand D	270..274	CDD:409353
		Ig strand E	276..280	CDD:409353
		Ig strand F	289..297	CDD:409353	2/7 (29%)
		Ig strand G	300..310	CDD:409353	3/17 (18%)
		Ig	313..395	CDD:416386	14/83 (17%)
		Ig strand A	314..319	CDD:409353	1/5 (20%)
		Ig strand A'	322..326	CDD:409353	0/3 (0%)
		Ig strand B	329..339	CDD:409353	4/10 (40%)
		Ig strand C	344..350	CDD:409353	0/5 (0%)
		Ig strand C'	351..354	CDD:409353	0/2 (0%)
		Ig strand E	368..374	CDD:409353	1/5 (20%)
		Ig strand F	381..389	CDD:409353	0/7 (0%)
		Ig	406..501	CDD:416386	20/109 (18%)
		Ig strand A	406..409	CDD:409353	0/2 (0%)
		Ig strand A'	415..419	CDD:409353	0/3 (0%)
		Ig strand B	422..431	CDD:409353	0/8 (0%)
		Ig strand C	436..442	CDD:409353	0/5 (0%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	452..460	CDD:409353	1/12 (8%)
		Ig strand E	464..473	CDD:409353	2/11 (18%)
		Ig strand F	480..488	CDD:409353	0/7 (0%)
		Ig strand G	491..501	CDD:409353	3/10 (30%)
		Ig	504..593	CDD:416386	27/149 (18%)
		Ig strand A	505..507	CDD:409353	1/40 (3%)
		Ig strand A'	512..516	CDD:409353	2/3 (67%)
		Ig strand B	519..526	CDD:409353	0/6 (0%)
		Ig strand C	533..539	CDD:409353	1/5 (20%)
		Ig strand C'	540..542	CDD:409353	1/1 (100%)
		Ig strand D	549..553	CDD:409353	0/3 (0%)
		Ig strand E	557..563	CDD:409353	2/5 (40%)
		Ig strand F	571..579	CDD:409353	2/7 (29%)
		Ig strand G	583..593	CDD:409353	2/9 (22%)
		Ig	596..686	CDD:416386	20/93 (22%)
		Ig strand A	597..599	CDD:409353	0/1 (0%)
		Ig strand A'	604..608	CDD:409353	0/3 (0%)
		Ig strand B	611..620	CDD:409353	2/8 (25%)
		Ig strand C	625..632	CDD:409353	0/6 (0%)
		Ig strand C'	634..636	CDD:409353	0/1 (0%)
		Ig strand D	643..648	CDD:409353	1/4 (25%)
		Ig strand E	651..658	CDD:409353	4/22 (18%)
Ig strand F	665..673	CDD:409353	5/5 (100%)
Ig strand G	676..685	CDD:409353
Ig_DSCAM	689..784	CDD:409397
Ig strand B	707..711	CDD:409397
Ig strand C	720..724	CDD:409397
Ig strand E	749..753	CDD:409397
Ig strand F	763..768	CDD:409397
Ig strand G	777..780	CDD:409397
Ig_DSCAM	785..885	CDD:409398
Ig strand B	805..809	CDD:409398
Ig strand C	818..822	CDD:409398
Ig strand E	849..853	CDD:409398
Ig strand F	863..868	CDD:409398
Ig strand G	876..879	CDD:409398
FN3	886..980	CDD:238020
FN3	987..1084	CDD:238020
FN3	1093..1185	CDD:238020
FN3	1190..1279	CDD:238020
Ig_3	<1303..1364	CDD:404760
Ig strand B	1304..1311	CDD:409353
Ig strand C	1317..1322	CDD:409353
Ig strand C'	1327..1333	CDD:409353
Ig strand D	1337..1341	CDD:409353
Ig strand E	1343..1347	CDD:409353
Ig strand F	1356..1364	CDD:409353
Ig strand G	1367..1377	CDD:409353
FN3	1381..1471	CDD:238020
FN3	1497..1568	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910