DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dci and CDYL2

DIOPT Version :9

Sequence 1:	NP_612065.1	Gene:	Dci / 38100	FlyBaseID:	FBgn0035169	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	XP_011521168.1	Gene:	CDYL2 / 124359	HGNCID:	23030	Length:	540	Species:	Homo sapiens

Alignment Length:	263	Identity:	74/263 - (28%)
Similarity:	130/263 - (49%)	Gaps:	27/263 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QGYKELLVEQQGKLLVAKFNNPKKKNCINRVAYQEMTRVLTEVNDDEGVTIVVFTGVGDIFTSGN 68
            :|:..:|:..|          ....|.:.....:|:.|.|.....|:. .:::.:.||.:|.||.
Human   292 EGFTHILLSSQ----------TSDNNALTPEIMKEVRRALCNAATDDS-KLLLLSAVGSVFCSGL 345

  Fly    69 DLSQ-----SSNTDDIDAFFKQSNATFKAM---VLSFVNCRKIVLALVNGPAIGIGATIVGLCDV 125
            |.|.     ||:..      |:|....:|:   |.:|:..:|.::..:||||:|:||:|:.|||:
Human   346 DYSYLIGRLSSDRR------KESTRIAEAIRDFVKAFIQFKKPIVVAINGPALGLGASILPLCDI 404

  Fly   126 AWCSETTYFYTPFTKLGLVPEGGSSYMLPLILGRSKASEILLLSEPLSAQEAYQFNFVSRIFKAS 190
            .|.||..:|.||:..:.|.|.|.|||..|.|||.:.|:|:|.....|:||||.....||::|..:
Human   405 VWASEKAWFQTPYATIRLTPAGCSSYTFPQILGVALANEMLFCGRKLTAQEACSRGLVSQVFWPT 469

  Fly   191 ELESVIWPKLRQYSELPTNSLLQGKRLVKDGFLENLIK-ANEAECKQLLQQFQHPEFAQAIIDFA 254
            .....:..::::.:......|.:.|.||: .||::::: .||.||..|.|.:...:...::..:.
Human   470 TFSQEVMLRVKEMASCSAVVLEESKCLVR-SFLKSVLEDVNEKECLMLKQLWSSSKGLDSLFSYL 533

  Fly   255 SRK 257
            ..|
Human   534 QDK 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dci	NP_612065.1	crotonase-like	9..197	CDD:119339	60/195 (31%)
CDYL2	XP_011521168.1	CHROMO	40..89	CDD:214605
CDYL2	XP_011521168.1	crotonase-like	286..482	CDD:119339	61/206 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1471901at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42274
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3644
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850