DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cep290 and GC5

DIOPT Version :9

Sequence 1:	NP_001261227.1	Gene:	cep290 / 38099	FlyBaseID:	FBgn0035168	Length:	1978	Species:	Drosophila melanogaster
Sequence 2:	NP_001185441.1	Gene:	GC5 / 844322	AraportID:	AT1G79830	Length:	976	Species:	Arabidopsis thaliana

Alignment Length:	1014	Identity:	202/1014 - (19%)
Similarity:	375/1014 - (36%)	Gaps:	231/1014 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1051 ESSQQLVKLIKSETQTRLLEQRCEILQAKQEELVRELGELRMSQATDTEHWSTIQALFGEGEPRS 1115
            |:..|:.:..:.....:|..::...::|.:|..||.    ...||.:.|...|:.....:.||:|
plant    91 ENPSQIEQKEEEAGSVKLATEQAVSVEANKETNVRR----EADQADNPEVTETVVLDPKDDEPQS 151

  Fly  1116 QLKVDAETNTDAVAPNLAMRRAVQLIDRESSPIGSPLRKHPHLD-TATQTLEAQVEFSETAVQTN 1179
            |:.::..:......|             |||...:.|:.:..|: ||:|..:.:...||......
plant   152 QILLEESSEYSLQTP-------------ESSGYKTSLQPNEKLEMTASQDSQPEQPKSEAEESQP 203

  Fly  1180 GILSQQNQAVQTADAVEDNRRDSRAELQKMQETLQEANQRIEILGKQLEASRSESRESASPQGGV 1244
            .....:...|:..|.|.....|.:.::..|.||..|.    ||||:.||...|......||....
plant   204 EDSEAKEVTVENKDTVHSPVLDGQHKITYMDETTNEQ----EILGENLEGRTSSKNFEVSPDINH 264

  Fly  1245 VEK--TILSFHTLLLEKDQSIQKYQDLLQTERDQSQQALSKQVAENESLRATVNNLNFNIKTKDA 1307
            |.:  :.::..:|:.|.|.|..:.....::..|:..:.:...|:.....|...:.||
plant   265 VNRIESPVAHPSLIFESDGSPYESSIPKRSSSDEISERIVDFVSREIDSRLDTSELN-------- 321

  Fly  1308 EIQGLKEKLRQKPEVPVERNPSTDSRSSSSSDSSVNELTDEKIEELFESSSVERPPQEELEVPVE 1372
                             |...|:.:.:.|.|...:.||...|.|.....::::...::     .:
plant   322 -----------------ESQRSSSATNVSDSADVILELEKTKKEIKMLENALQGAARQ-----AQ 364

  Fly  1373 AGPENIVTEEPEGEEEKQDTEELKEVPTLHKQIKDLKDKLEYSERSLKTREEEVDIL-KEKLKLC 1436
            |..:.|.....|.|:.|..||:||. .:...:::.|::  ||.:| :.|.|.:|..| ||:..|.
plant   365 AKADEIAKLMHENEQLKSVTEDLKR-KSNEAEVESLRE--EYHQR-VATLERKVYALTKERDTLR 425

  Fly  1437 QEREKSVESTVNPELDQLRIFLDEKDKHIKDLMDTLKNFHDDQ----------QRYIKDTSNFSE 1491
            :|:.|..::..         .|.|||:.|..:|...:.....|          :..|::.....:
plant   426 REQNKKSDAAA---------LLKEKDEIINQVMAEGEELSKKQAAQEAQIRKLRAQIREAEEEKK 481

  Fly  1492 DQIAKLAADLNRTE-------ATNKIYHTQMEALRRQLANVTQREKQARDLSQSLRQQLLKRPVV 1549
            ..|.||.::.|:.|       ||.|:....:|  :.|....:|::..:..|:.:...|.|...
plant   482 GLITKLQSEENKVESIKRDKTATEKLLQETIE--KHQAELTSQKDYYSNALAAAKEAQALAEE-- 542

  Fly  1550 SIKTELNARVKNENQLK----RIQQLELDLDEARGQLQRQQTLLEAKRTRSANEVQLWEKQKRYQ 1610
              :|...||.:.||:||    |...|...|:|.|..|.:::.....:......|::  :.|:|||
plant   543 --RTNNEARSELENRLKEAGERESMLVQALEELRQTLSKKEQQAVYREDMFRGEIE--DLQRRYQ 603

  Fly  1611 -------------------------------QQAEKTKARLEETE-------------LALEKT- 1630
                                           |..|.|:..|.:.|             .|:|:|
plant   604 VKSRCFVVSMHISFFGYRLLASERRCEELITQVPESTRPLLRQIEAMQETSYRTAEAWAAVERTL 668

  Fly  1631 RALLQAARTTIARLEKDKQILESKLGRNGPPSNSSGGNNLKCCRTPSCPNLQHVGVSKFAPSPSE 1695
            .:.||.|.:..|..|:.::.:..:|.:                      .|..:.|.:
plant   669 NSRLQEAESKAATAEERERSVNERLSQ----------------------TLSRINVLE------- 704

  Fly  1696 SPETYTGPSSECSSPAHHHTQIFDQSQLDLIEALKSRIELQQRKIIAMELEGRGSNALTTELEKL 1760
                     ::.|.......|:....:.:...|.::|.|....|..|..|||| :|.|..|:.:|
plant   705 ---------AQLSCLRAEQGQLSKSLEKERQRAAENRQEYLAAKEEADTLEGR-ANQLEVEIREL 759

  Fly  1761 QERCQAIEAQNIRLEARNLQLQLDSDLLRQGDSSDRLQ-KRIKHLEDYIMALKEEMARNESRREL 1824
            :.:.:. |.|.:.|....:|..|:.      :.:.||. :|...:....::.:..:||..|..|.
plant   760 RRKHKQ-ELQEVLLHNELIQKDLER------EKASRLDLERTARINSSAVSEQLPIARQNSAFEN 817

  Fly  1825 GS---GLKVSTNQGQSAEQTILSLRNLVEKLRSENKFLKDGRRSTESRSSMDST----------- 1875
            ||   .|..:::.|...|...|.     ..|.|.:||       :|.||..::|
plant   818 GSLPRKLSSASSLGSMEESYFLQ-----ASLDSSDKF-------SEKRSMPEATMSPYYMKSITP 870

  Fly  1876 PAEAARLQQQHAE---------ALEKI-SALQQELQKRTTKCSQCGGRSK--DAANEELKFIKEQ 1928
            .|..|.|:|:..|         ::|.| .:|.:||.|.|.:|.:..|.:.  .....||:.::::
plant   871 SAYEATLRQKEGELASYMTRLASMESIRDSLAEELVKMTAECEKLRGEADRVPGIKAELEALRQR 935

  Fly  1929 LVKKTQLL----QKAKVLLTRAAAKEKVLREQLALWKRK 1963
            .....:|:    ::.:.|.......:::.|||:.:...|
plant   936 HAAALELMGERDEELEELRADIVDLKEMYREQVNMLVNK 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cep290	NP_001261227.1	SMC_prok_B	208..>973	CDD:274008
GC5	NP_001185441.1	TMF_DNA_bd	432..505	CDD:289127	14/81 (17%)
GC5	NP_001185441.1	TMF_TATA_bd	859..971	CDD:289123	22/111 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000