DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cep290 and cep290

DIOPT Version :9

Sequence 1:NP_001261227.1 Gene:cep290 / 38099 FlyBaseID:FBgn0035168 Length:1978 Species:Drosophila melanogaster
Sequence 2:XP_009296179.1 Gene:cep290 / 560588 ZFINID:ZDB-GENE-041111-243 Length:2741 Species:Danio rerio


Alignment Length:2529 Identity:532/2529 - (21%)
Similarity:966/2529 - (38%) Gaps:710/2529 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSMD----------IPETVSLRKFRDFSARQKQELY------ETLLELA--------ESIDELPK 41
            |.||          |.:.:.:.|.||..|...:::.      :|||.:.        |.:|....
Zfish    11 MGMDPEDLGDEDEKICDLILMVKPRDLKADDSEKMIQLFRISQTLLRMKLDEIKCAYEVVDSAGA 75

  Fly    42 KSLRKTLELTLAVLEYKGEQVQQLQESAAGGLSSDRR-LQDENEKLKRMLQKLEDERDGLKSKAK 105
            :..|...||...||:.:.| ::..|....||   |:. |:||..:|:..|::.|.|...|:   |
Zfish    76 EQARIENELKAKVLKLESE-LEMAQRVMGGG---DKHFLRDEIRQLESHLERKEKEVTQLE---K 133

  Fly   106 ELGEEIR---QLELRLQEAAQQAEISDKDSSDPLSELD-KQEQLLQNIDSKNK--------HIKR 158
            |:|:|.:   :|.||    |::||..::.....:.:|. |.|||.|:|:...|        ..|.
Zfish   134 EMGKERKSNEELALR----AEEAEEKNRKLKREIKQLTRKNEQLQQDIEFYRKEAEQRESLQTKE 194

  Fly   159 LLKEIE---TLQNQNIAQSKTIVLHEREL--------QTIKANLVQLSQDITKVEQERKSLKQKE 212
            ...||:   |..||.:.|....:.|..::        :.::.||.:..:::.|:..|...:|   
Zfish   195 ESNEIQRRLTKANQQLYQCMEELQHAEDMAANLRSENEHLQKNLEESVKEMEKMTDEYNKMK--- 256

  Fly   213 QQQALEITRLEGNLTFLEVEREKQEVEMRQFLDKYE--------------AKSLGWRQALDDRDK 263
                :.:.:.:..:..|..:|:..::::|:..|:.:              ||...|:..|..:|.
Zfish   257 ----IAVQQTDAIMDQLRKDRDHAKLQVRELTDQIQARVEEDDPVMAAVNAKVEEWKSVLSGKDL 317

  Fly   264 EV---ERLKKQLEGKSISSGQTNS--SNSQSQQEEEHAKLRQLLESREQRIEKLEEKIKSMAEEM 323
            |:   :::.:.|..| :.:.|.:|  ||..:.|:..: :|...::.|:.:|:.|.|:::....||
Zfish   318 EILEYQQMIRDLREK-LRTAQMDSDKSNIIALQQVIY-ELCGAVQERDNQIKMLSEQVEQYTTEM 380

  Fly   324 VSSTRAMNQLCQ--EKERAHDPEQPR------ACCQMIEERLREATARCQQLSEMLEAAEQDNVL 380
            ..:...:.:|.:  :|::.|..:..|      |..|:.|.::.|| .|..||:|. :|.::|..|
Zfish   381 ERNAMLIEELKRPLKKDKGHSSDHQRRLEDLSAKLQVAERKVLEA-QRAAQLAER-DARDKDKEL 443

  Fly   381 KSQQALHAISALEAYKRDEDGLIPALRRCSGLEQKVAARDKQLRAYIQELNSL----HEVVQENE 441
            ..     .:|.:..|:...|||..|:......:.::..||:::...|:|:|.|    :.::.|||
Zfish   444 ND-----TLSRIRLYESGTDGLEAAISEIKECKNQIRVRDREIEGMIKEINQLEMKINNLLDENE 503

  Fly   442 LLRRKLHI-PDDVVIMAKNVHS---KQRNKD-------KQIERLTLKLRTSEELRLQLK------ 489
            .||.:|.: |.:.:.:::...|   |||...       |:||||       ||.||:||      
Zfish   504 DLRERLGLNPKEELDLSEFRRSKILKQRQYKAENQVLLKEIERL-------EEERLELKQRIRAL 561

  Fly   490 -------------LEKSELRRKLLELQQDSPQT------LNESLQAPSEVGEVPHSVHLENSPRR 535
                         |:.|...:.:..|:..|..|      .||.||  .|:......:.|..|   
Zfish   562 VKDKGVTVVSNSLLDNSVEEKPVRSLRPSSGSTDDEIKRKNERLQ--KELSNKEKELELRRS--- 621

  Fly   536 GQGDGAASSEMQNRYDEVLAENETLRSGMYEILEKLREYD---ATSEHITIDSDLLRRLIEAL-- 595
                  .|::.:.:.:|:|.||:.|..||.|||:.:::..   .||..::|.|  |.||:.||  
Zfish   622 ------ESTQFKAKLNEMLNENKQLEQGMKEILQAIQDTQKKTPTSTGVSIPS--LERLVNALEM 678

  Fly   596 ---PGGTTTPQRLQGQLLELKAREEALRQ------------------------LLEQQNYSDSET 633
               .|.......|:.|:.:|..|.|.|||                        .||.:..|.|::
Zfish   679 KYSEGKFDASLHLRTQVDQLTGRNEELRQEMKTAREEAANTLSQLTKANEKIARLESEMESMSKS 743

  Fly   634 GELSSVHSLCEVPEIAEEHPVEEDAV--LNTAT-------------------------RPSSPTE 671
            ...|..|....:||  |..|...:|:  ||..|                         |..:...
Zfish   744 TGSSIPHKTLALPE--EMTPTSAEAINALNEYTVQLLQEIKNKGDSIEQLGSALEEYKRKFAVIR 806

  Fly   672 ATMGLRRPTVPDPEE--KPTNEALAEL-----------SILRKHYDELRLHMSADGSDLMNRNQE 723
            ...||.........|  :...::.|||           ::..|.|:.|...:..|.|::.....|
Zfish   807 HQQGLLYKEHQSERESWQKERDSFAELKSKLEEQREVDAVKIKEYNHLLETLEKDPSEIRREMAE 871

  Fly   724 LHDQMIALE-------------LQLEQQ-RNSYSYMRRDYDQL---LTETRKQELRFID----DK 767
            ...:::.|.             |:|||. |...:.::.|:.|:   :||......||.:    ..
Zfish   872 TGRKIVVLRVNEKCLTRRYTTLLELEQHLRKENAKLKEDFTQMQAAVTERIGYLQRFKEMAAFKM 936

  Fly   768 ASLAR----------------------------------------QLEHSKSELCEAREELEQVN 792
            |||.:                                        .|||.::|....||.::.:|
Zfish   937 ASLQKSLDVSVPASELERANKQYTELTIKYRNLLQKDNHLVQKTTSLEHLETENMSLRERIDSIN 1001

  Fly   793 ------RRNLYTAE-------------------------------------------EQQKLEHR 808
                  :..|:|.|                                           |:|:.|| 
Zfish  1002 KELEISKEKLHTLEQAFENISTTGGEIIMDKATKAVANSEIVSVSRRITTLEMKELNERQRAEH- 1065

  Fly   809 NAILSMQLGQAM-EQLLGELKPTEICAEYGIIRENYQLD---------YITAQDFE-EQQQELLT 862
                    .|.| |.|...||..|        ..|::|:         .:.||..| |.:.||..
Zfish  1066 --------AQKMYEHLRNSLKQVE--------ERNFELETKFAELTKLNLEAQRIERELRDELAD 1114

  Fly   863 WRSK----------------QAELQRETKQLEGLLHVANEQIHS----QQRLLNEITDNHINLRH 907
            ..||                :|.|:.|..:|..:..||..|:.:    ||....|:.    :||.
Zfish  1115 SVSKHISDADRKRITELEKTEANLRIEVSKLREVSDVAKMQVSALDARQQSREKEVE----SLRR 1175

  Fly   908 LVADLQSSSDEKLMLAKVQRDLDSVK----AECSRLETEREKLQLKADCLQTQLEASELSLKQTQ 968
            .|.|.|:.||||.::||:.:.:.:::    ...||||....:||.    |:.|....|..|.:.|
Zfish  1176 QVLDYQAESDEKALIAKLHQHIVALQLSETTAISRLEATNTRLQK----LEAQKLRDEQKLDEQQ 1236

  Fly   969 QDFQQERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQR---RLEEEQVQQRHRD 1030
            |.....|.....:.:.|:|::..|:.:::...||.       ..:||..   .|:|::.  |.|:
Zfish  1237 QALWHARQEGHQRARHLRHTIQALRRQFSGALPLA-------QQEKFSNTMLHLQEDRA--RVRE 1292

  Fly  1031 HTALIDEVTAVVQAKI--------GLNE--------ESSQQLVKLIKSETQTRLLE--------- 1070
            ...:.:|.....:.|.        ||.|        :.:|::.:..|.....||||         
Zfish  1293 DAQITEEERRKAEGKAQELELKLKGLEELIATLKDAKGAQKVSEWHKKLEDVRLLEMRQSRELNT 1357

  Fly  1071 QRCEI-----LQAKQEELVRELGELRMSQATDTEHWSTIQALFGEGEPRSQLKVDAETNTDAVAP 1130
            ||.||     ..|:||..:..|.|..:.|....|.   .|.::.:.|.:.:.::|:.........
Zfish  1358 QREEIKYLKNCVAEQERTISGLEEELVQQNNLLEE---RQLIWDQREVQLERQLDSYEKQQNEVL 1419

  Fly  1131 NLAMR--RAVQLIDRESSPIGSPL-------RKHPH--LDTAT--QTLEAQVEFSETAVQTNGIL 1182
            |.|.:  .|...:...:.|:.:.|       ::|..  |:|.|  :.||.:::..|.|:.:    
Zfish  1420 NTAQKFEEATGSLPDPNQPLANQLDYALGKIKEHVRTILETKTTCKILEEKLKEKEAALWS---- 1480

  Fly  1183 SQQNQAVQTADAVEDNRRDSRAELQKMQETLQEANQRIEILGKQLEASRSESRESASPQGGVVEK 1247
            |:||  |.:.|.|          :.:::..|..|.:|.::|.   :.|:.|..|| .|...|..:
Zfish  1481 SEQN--VLSRDKV----------INELRLRLPAAAEREKLLA---DLSKQEDSES-QPTLKVAHQ 1529

  Fly  1248 TILSFHTLLLEKDQSIQKYQDLLQTERDQSQQALSKQVAENESLRATVNNLNFNIKTKDAEIQGL 1312
            ||.:....|.:|::.::|||:||...| |.|:.::|:  ..|.:||....|:..:.|.....:..
Zfish  1530 TINNLQGRLDQKEEVLKKYQNLLGKAR-QEQEEIAKR--HEEEVRALHQKLDVYMDTSLDRFKQT 1591

  Fly  1313 KEKLRQKPEVPVERNPSTD--------SRSSSSSDSSVNELTDEKIEELFESSSVERPPQEELEV 1369
            ..:|.:||.:.|   |::.        .::.:..|:|::.|: :|::.:.:....:|  |.....
Zfish  1592 ALELIKKPTITV---PTSKHLVRLAEMEQTVAEQDNSLSSLS-QKLKIVTQELDQQR--QVTAAQ 1650

  Fly  1370 PVEAGPENIVTEEPEGEEEK---QDTEELK-EVPTLHKQIKDLKDKLEYSERS-----LKTREEE 1425
            .:|...:....|:....:.|   |:.|||: ::..:.|::..|:.:||..:.:     ..|.:..
Zfish  1651 AMEHAADMARLEDKHAAQMKGLSQEAEELRAQLIQMEKELHYLRTELEAQKEANVRSPSNTMKNL 1715

  Fly  1426 VDILKEKLKLCQEREKSVESTVNPELDQLRIFLDEK----------------------DKHIKDL 1468
            |:.||.:|.|   :||.::: ::..|.:||..|..:                      ||..|:|
Zfish  1716 VERLKNQLAL---KEKQLKA-LSKALLELRAELTSQAEQQIITNAAQKEEALNVQQIVDKQTKEL 1776

  Fly  1469 MDTLKNFHDDQQ------RYIKDTSNFSEDQIAKLAADLNRTEATNKIYHTQMEALRRQLANVTQ 1527
            ...:::.:::.|      |..|...|..::.:..|..||.|::.:.               |..|
Zfish  1777 RACVRDLNEELQLAKDGVRAAKARENSLKEDLETLNKDLQRSQKSQ---------------NKLQ 1826

  Fly  1528 REKQARDLSQSLRQQLLKRPVVSIKTELNARVKNENQL-----KRIQQLELDLD--EARGQLQRQ 1585
            .||:|  |.:.|.:  ||:.:..:.:.|.|:|:::...     |:|::||.:||  .......::
Zfish  1827 SEKEA--LEEHLNE--LKKKIQRLSSGLQAQVESDGPTVDALQKKIRKLEHELDRKSISEPADKR 1887

  Fly  1586 QTLLEAKRTRSANEVQLWEKQKRYQQQAEKTKARLEETELALEKTRALLQAARTTIARLEKDKQI 1650
            .||.|.|  .|..||..||:.|::|.:.:|.:..|:|.|..::.....|...:...:|||::|..
Zfish  1888 STLKEDK--SSKEEVVRWEEGKKWQARVDKMRNVLKEKEREVDSQAKQLATMKELYSRLEQEKVS 1950

  Fly  1651 LESKL-GRNGPPSNSSGGNNLKCCR------------------------TPSCPNLQHV------ 1684
            |:.|| ||........|...|:..:                        .|....::.:      
Zfish  1951 LQKKLKGRGVTADQVVGARTLEADKEIEELHKRNAELEQQIKVMKQQQALPRDAAMEDITNRNRY 2015

  Fly  1685 ----------GVSKFAPS-PSE----SPETYTGPS------------SECSSPAHHHTQIFDQSQ 1722
                      .:||..|| ||:    ||...:..|            .:..|...:.|.:..:.:
Zfish  2016 LEERLYSMESRLSKEPPSRPSDRHSTSPSQLSWSSKVRSMTFDVIEAEQTQSSLLNSTVVVTEKE 2080

  Fly  1723 LDLIE------------------------ALKSRIELQQRKIIAME-LEGRGSNALTTELEKLQE 1762
            :.:||                        ..|::|:|:|:.::..: .|...||.....:||.:|
Zfish  2081 ISVIEDKATQTSFRSIDMGTAEVNQDDENVAKNKIDLEQKALMKDDKTEQEESNKEKGSVEKDEE 2145

  Fly  1763 RCQAIE-AQNIRLEARNLQLQLDSDLLRQGDSSDRLQKRIKHLEDYIMALKEEMARNESRRELGS 1826
            :....: .|::.:      .:...:.|:..|.::.|:..:.|.|.....|.|:....|:......
Zfish  2146 QPDETQRGQDVAV------FEYAQEELKTNDEAEELESELTHREMMEKPLDEDQLEVENEETNAE 2204

  Fly  1827 GLKVST-NQGQ-----------------------------------SAEQTILSLRNLVE-KLRS 1854
            .:..|| ||.:                                   ..|:|.||.....: ||.|
Zfish  2205 EMLYSTMNQAELETPKVLLEGDEDYGQEPEELLKCECDPSAESKELDEEETALSNSTTFDAKLVS 2269

  Fly  1855 ENKFLKDGRRSTESRS-----SMDSTPAEA-ARLQQQ---HAEALEKISALQQELQKRTTKCSQC 1910
            |...::..:..|....     |..||..|. |..:..   |.:|  |::.|..:.....:|..:.
Zfish  2270 EQPAMEKNKSFTPEAGFNPNLSEVSTSRELNANTENDILGHLKA--KVTRLNDKEHSMKSKARKT 2332

  Fly  1911 GGRSKDAANE-ELKFIKEQLVKKTQLLQKAKVLLTRAAAKEKVLREQLALWKRKCSELQ 1968
            .||..|..:: |.:|.||.|...|:.|: .:..|.:|......|::|::..|..||.|:
Zfish  2333 SGRGSDTPSQREHEFQKENLRLSTENLE-LRFQLEQANKDLPRLKDQVSDLKEMCSVLK 2390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cep290NP_001261227.1 SMC_prok_B 208..>973 CDD:274008 222/1048 (21%)
cep290XP_009296179.1 DUF342 <77..185 CDD:302792 36/123 (29%)
Smc 131..1004 CDD:224117 249/1176 (21%)
SMC_prok_B 1125..1992 CDD:274008 213/1050 (20%)
CEP209_CC5 1279..1406 CDD:293182 28/137 (20%)
SMC_prok_B 1781..2650 CDD:274008 49/245 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28HFX
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D19529at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR18879
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
65.970

Return to query results.
Submit another query.