Protein Alignment cep290 and alm1

DIOPT Version :9

• Sequence 1: NP_001261227.1
• Gene: cep290 / 38099
• FlyBaseID: FBgn0035168
• Length: 1978
• Species: Drosophila melanogaster
• Sequence 2: NP_594092.1
• Gene: alm1 / 2542883
• PomBaseID: SPAC1486.04c
• Length: 1727
• Species: Schizosaccharomyces pombe
• Alignment Length: 2125
• Identity: 443/2125 - (20%)
• Similarity: 799/2125 - (37%)
• Gaps: 662/2125 - (31%)

  Fly     4 DIPETVSLR-----------KFRDFSARQKQELYETLLELAESIDELPKKSLRKTLELTLAVLEY 57
            ||...||:.           |.:|.:|.:.|      |.|.|...|..:..|.|.:..    ||
pombe    23 DIKPLVSVNGFAVFISAIKTKVKDINALKDQ------LVLQEVNHEHKENVLTKKINF----LE- 76

  Fly    58 KGEQVQQLQESAAGGLSSDRR-----LQDENEKLKRMLQKLEDERDGLKSKAKELGEEIRQLELR 117
                 ||||.|  ...:.:.|     |::|||.||..|:......|.|.::    .:.:|:....
pombe    77 -----QQLQSS--NNQAEESRNLISVLRNENESLKTNLENQNKRFDALTTE----NQSLRRANSE 130

  Fly   118 LQEAAQQAEISDKDSSDPLSELDKQEQLLQNIDSKNKHI-------KRLLKEIETLQNQNIAQSK 175
            |||       ..|.:|:.||....|.:.|||   :|.|:       .:.|.:||..:.|::..|.
pombe   131 LQE-------QSKIASEQLSIAKDQIEALQN---ENSHLGEQVQSAHQALSDIEERKKQHMFASS 185

  Fly   176 TIVLHERELQTIKANLVQLSQDITKVEQERKSLKQKEQQQALEITRLEGNLTFLEVEREKQEVEM 240
            :..:.|..|...|:.||   .|:..::.:...:.:|.:..:.::..||..|..|    .:|..|:
pombe   186 SSRVKEEILVQEKSALV---SDLASLQSDHSKVCEKLEVSSRQVQDLEKKLAGL----AQQNTEL 243

  Fly   241 RQFLDKYEAKSLGW------RQALDDRDKEVERLKKQLEGKSISSGQTNSSNSQSQQEEEHAKLR 299
            .:.:..:|.|...:      .:.|:.....::.|::::|.:...:....|.:|:.|.|.  |.|:
pombe   244 NEKIQLFEQKRSNYSSDGNISKILETDPTSIKELEEEVETQKRLTALWESKSSELQSEV--AALQ 306

  Fly   300 QLLESREQRIEKLEEKIKSMAEEMVSSTRAMNQLCQEKERAHDPEQPRACCQMIEERLREATARC 364
            :.|.|::.....:.|::.:..::::.|..::.:| |||   :|
pombe   307 EKLTSQQSLYNNVTEELNNNKQQLLISENSLREL-QEK---YD---------------------- 345

  Fly   365 QQLSEMLEAAEQDNVLKSQQALHAISA-----------LEAYKRDEDGLIPALRRCSGLEQKVAA 418
            ..:||:....|..|.        ::||           |.|.:..|............|:|||::
pombe   346 SVVSELQVVKENKNT--------SVSAGVGLFSPLAQKLSAVQNPEFSFTKVYSDNMKLQQKVSS 402

  Fly   419 RDKQLRAYIQELNSLHEVV---------QENELLRRKLHIPDDVVIMAKNVHSKQRNKDK-QIER 473
            ...||.....:.:|..|.|         |.:|::|..:::.    .:::::.:...|..| |.|.
pombe   403 LKLQLDRLTNKFSSFCEQVKQRIPVVKQQRSEIVRNNIYMN----FLSESLETSNNNLTKVQAEL 463

  Fly   474 LTLKLRTSEELRLQL---KLEKSELRRKLLELQQDSPQTLNE--SLQAPSEVGEVPHSVHLENSP 533
            |:.|:| .|...|||   :.:.|:|.|:::.|..:... |||  |...|:.|     .|.|:
pombe   464 LSTKMR-QEACYLQLTASRTQCSDLSREVICLMAELDH-LNETKSRNVPATV-----QVALD--- 518

  Fly   534 RRGQGDGAASSEMQNRYDEVLAENETLR---SGMYEILEKLR--EYDATSEHITIDSDLLRRLIE 593
            ...|....||..:.|:   .||...:::   |...|:.||:|  |.|...:..|:...:...:.|
pombe   519 EYAQNPSTASETLVNK---ELANFSSIKEAVSKTLELREKVRALECDVEIQKQTVQYQISNAVKE 580

  Fly   594 ALPGGTTTPQ--RLQGQLLELKAREEAL---RQLLEQQNYSDSETGELSSVHSLCEVPEIAEEHP 653
              ...|.:.|  .|:.:|...|.:.|:|   |.||::. .:.|.:..||...|...:
pombe   581 --NSNTLSEQIKNLESELNSSKIKNESLLNERNLLKEM-LATSRSSILSHNSSAGNI-------- 634

  Fly   654 VEEDAVLNTATRPSSPTEATMGLRRPTVPDPEEKPTNEALAELSILRKHYDELRLHMSADGSDLM 718
                                         |.:.|..:|:..|   |.|:|:..|..|:|....|.
pombe   635 -----------------------------DDKMKSIDESTRE---LEKNYEVYRNEMTAIQESLS 667

  Fly   719 NRNQELHDQMIALELQLEQQRNSYSYMRRDYDQLLTETRKQELRFIDDKASLARQLEHSKSELCE 783
            .|||:|..:|.|:..:||..:         |.|.|:..|                       |..
pombe   668 KRNQDLLSEMEAIRKELENSK---------YQQQLSTDR-----------------------LTN 700

  Fly   784 AREELEQVNRRNLYTAEEQQKLEHRNAILSMQLGQAMEQLLGELKPTEICAEYGIIRENYQLDYI 848
            |..::|                             |.::...||:.         |.:|.| |.|
pombe   701 ANNDVE-----------------------------AFKKEAKELRS---------INQNLQ-DII 726

  Fly   849 TAQDFEEQQQELLTWRSKQAELQRETKQLEGLLHVANEQIHSQQRLLNEITDNHINLRHLVADLQ 913
            :.||                  ||.:|..|.||||            |.:.:      .|..:|.
pombe   727 SRQD------------------QRASKFAEELLHV------------NSLAE------RLKGELN 755

  Fly   914 SSSDEKLMLAKVQRDLDSVKAECSRLETEREKLQLKADCLQTQLEASELSLKQTQQDFQQERTNS 978
            :|..||.:..:.|..|.|   |..:|..|||:|......|||.|...:||....:..|:.|:.:
pombe   756 ASKGEKDLRKRTQERLIS---ENDKLLAERERLMSLVSDLQTFLNQQQLSDAARKVKFESEKES- 816

  Fly   979 DIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQRRLEEEQVQQRHRDHTALIDEVTAVVQ 1043
                  |..||..||:...|      ::|.:.:.||   .||:..::...|..|.::::
pombe   817 ------LSLSLQKLKESNEK------MSNDLHSLQK---SLEKSGIEYSSRIKTLMLEK------ 860

  Fly  1044 AKIGLNEESSQQLVKLIKSETQTRLLEQRCEILQAKQEEL--VRELGELRMSQATDTEHWSTIQA 1106
                      |.|     ||...:||:.: ::::.|.:||  |.||         :.:.:||::|
pombe   861 ----------QSL-----SEDNRKLLDNQ-QMMEIKLQELNGVIEL---------EKQRFSTLEA 900

  Fly  1107 LFGEGEPRSQLKVDAETNTDAVAPNLAMRRAVQLIDRES------SPIGSPLRKHPHLDTATQTL 1165
            .|      :|.|..:.:..:|:..:       .|.|.:|      |.....||....|..|::..
pombe   901 KF------TQQKNTSYSEREALLES-------SLSDLQSKHTSLESQYNYSLRNIEQLQAASKLA 952

  Fly  1166 EAQVEFSETAVQTNGILSQQNQAVQTADAVEDNRRDSRAELQK---MQETLQEANQRIEILGKQL 1227
            |..||..:|        ......:||::::|.|.....:..|:   :|:.:..::.|.|.:.|.
pombe   953 EEMVERVKT--------EYDEYRLQTSESLEKNHLKITSLEQRIVILQDEIASSSLRCENITKD- 1008

  Fly  1228 EASRSESRESASPQGGVVEKTILSFHTLLLEKDQSIQKYQDLLQTERDQSQQALSKQVAENESLR 1292
                ||:|.:                 ||||:::.:   .:.|.:.|:..:|.|.|:....:.|.
pombe  1009 ----SETRVA-----------------LLLEENKHL---NNELSSHRNAEKQHLEKENDYKQQLL 1049

  Fly  1293 ATVNNLNFNIKTK-DAEIQGLKEKLRQKPEVPVERNPSTDSRSSSSSDSSVNELTDEKIEELFES 1356
            ....:|.   ||: |.|    ||.||.           .|:||           |.:|:.|.: :
pombe  1050 LVTEDLR---KTREDYE----KELLRH-----------ADARS-----------TLQKLREDY-T 1084

  Fly  1357 SSVERPPQEELEVPVEAGPENIVTEEPEGEEEKQDTEELKEVPTLHKQIKDLKDKLEYS------ 1415
            .::|:......|:.::||   |...:|....||:|... :||..|.||...|..:|:.|
pombe  1085 KALEQVEDLNKEIALKAG---INESQPFPISEKEDPLR-QEVYVLKKQNAMLLTQLQSSNLNFAE 1145

  Fly  1416 -------------------ERSLKTREEEVDIL----------KEKLKLCQE------------- 1438
                               :..:|...:|::|:          .:|||...|
pombe  1146 ITSPSPDLDSVMKLGLSDLQNHVKRISKEMEIISCQRQLLFLENKKLKRTVESSNRVIADLQRGI 1210

  Fly  1439 REKSVEST----------------VNPELDQLRIFLDEKDKHIKDL---MDTLKNFHDDQQRYIK 1484
            .||.|.||                :|.....||..|:..::.|.:|   ::|||.
pombe  1211 TEKDVSSTSESVGERSNYLNMVALLNESNKSLRENLERNEEVITELREKIETLKT---------- 1265

  Fly  1485 DTSNFS------EDQIAKLAADLNRTEATNKIYHTQMEALRRQLANVTQREKQARDLSQSL--RQ 1541
            |.:||.      |.|:....|.:.:.|.:|:.|....:.:...|.:.|.....|..|...|  ::
pombe  1266 DLANFRLNKEQLESQLQTEKAAVKKLENSNEEYKRHNQEILLSLNSSTSTSSDASRLKNELVSKE 1330

  Fly  1542 QLLKRPVVSIKTELNARVKN-ENQLKRIQQLELDLDEARGQLQRQQTLLEAKRTRSANEVQLWEK 1605
            .|::        |||..:.: :::|:.::....||:..|.|.|.:...||.|.|:.|   ..|
pombe  1331 NLIE--------ELNQEIGHLKSELETVKSKSEDLENERAQNQSKIEQLELKNTKLA---AAW-- 1382

  Fly  1606 QKRYQQQAEKTKARLEETELALEKTRALLQAARTTIARLEKDKQILESKLGR--------NGPPS 1662
            :.:|:|...|          :|||...:.|       :|.:....||:|:..        |.|.:
pombe  1383 RTKYEQVVNK----------SLEKHNQIRQ-------QLSQKTSELEAKVAECHQLNEQLNKPSA 1430

  Fly  1663 NSSGGNNLKCCRTPSCPNLQHVGVSKFAPSPSESPETYTGPSSECSSPAHHHTQIFDQSQLDLIE 1727
                        ||:       ..::..|| :.|.|.:.....|.||.....::|     :|::.
pombe  1431 ------------TPT-------ATTQSEPS-TVSLEEFNSTKEELSSTQRKLSEI-----MDILN 1470

  Fly  1728 ALKSRIELQQRKIIAMELEGRGSNALTTEL--EKLQERCQAIEAQNIRLEARNLQLQLDSDLLRQ 1790
            ..|.  ||::.:..:.:.||...:   ||:  |:..||.:.::.:.:||.:|         :.::
pombe  1471 TTKE--ELEKVRQNSNKSEGTSKD---TEIPNEEEMERKKVMQQEVLRLRSR---------IAKE 1521

  Fly  1791 GDSSDRLQKRIKHLEDYIMALKEEMARNESRRELGSGLKVSTNQGQSAEQTILSLRNLVEKLRSE 1855
            ...::.|:|:.:.|:|.:.||:|.:              ||:.:.:||            .:.::
pombe  1522 LQKNELLRKQNQVLQDQVKALQETV--------------VSSEEAESA------------SVHAD 1560

  Fly  1856 NKFLKDGRRS------------TESRSSMDSTPAEAARLQQQHAEALEKISALQQELQKRTTKCS 1908
            .|.|::.:::            .||.|...::.|:.....|:..|...:|  ||::::::..:..
pombe  1561 TKDLENLKKTEEMLSVTFQVIFNESISDFSTSTADFTTFVQKEWEKRREI--LQKDVEEQVAQSH 1623

  Fly  1909 QCGGRSKDAANEELKFIKEQLVKKTQLLQK--AKVLLTRAAAKEK 1951
            |   :..|...:||: ::.:|  |..:|:|  |:|......:|:|
pombe  1624 Q---KQLDNIRKELE-MRNKL--KLSMLEKNLARVRAELEQSKKK 1662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cep290	NP_001261227.1	SMC_prok_B	208..>973	CDD:274008	166/806 (21%)
alm1	NP_594092.1	Smc	84..885	CDD:224117	223/1065 (21%)
		SMC_prok_B	764..1567	CDD:274008	216/1037 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000