DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cep290 and Cep120

DIOPT Version :9

Sequence 1:	NP_001261227.1	Gene:	cep290 / 38099	FlyBaseID:	FBgn0035168	Length:	1978	Species:	Drosophila melanogaster
Sequence 2:	NP_848801.2	Gene:	Cep120 / 225523	MGIID:	2147298	Length:	988	Species:	Mus musculus

Alignment Length:	1290	Identity:	234/1290 - (18%)
Similarity:	416/1290 - (32%)	Gaps:	477/1290 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 SSDPLSELDKQE---QLLQNIDSKNKHIKRLLK-----EIETLQNQNIAQSKT--IVLHERELQT 186
            ::||:...|:.|   :|...||.|..|..||.:     :...|..|..|:...  |||..|..|.
Mouse    40 ATDPVDHTDQPEFATELAWEIDRKVLHQHRLQRTPIKLQCFALDPQTSAKETVGYIVLDLRTAQE 104

  Fly   187 IKAN---LVQLSQDITKVEQERKSLKQKEQQQALEITRLEGNLTFLEVEREKQEVEMRQFLDKYE 248
            .|..   ...||...||.:.|                 ::.:|| ||.:.:.|       :|.|:
Mouse   105 TKQAPKWYQLLSNKYTKFKAE-----------------VQISLT-LETDTKAQ-------VDSYK 144

  Fly   249 AKSLGWRQALDDRDKEVERLKKQLEGKSISSGQTNSSNSQSQQEEEH--------------AKLR 299
            ||      |...||.:|......::.|.|.:..............||              .:|.
Mouse   145 AK------AAPPRDGKVLASLAGVDPKDIVAVLNEEGGYHQIGPAEHCTDPFILSVTIAFATQLE 203

  Fly   300 QLLESREQRIEKLEEKI-------KSMAEEMVSSTRAMNQLCQEKERAHDPEQPRACCQMIEERL 357
            ||:....:..|:..|..       ..:..|..|.....|   .|.|||             ..|:
Mouse   204 QLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFSDLINPN---FEPERA-------------SVRI 252

  Fly   358 REATARCQQLSEMLEAAEQDNVLKSQQALHAISALEAYKRDEDGLIPALRRCSGLEQKVAARDKQ 422
            |.:.                .:|:...|||  |.|:            :..|.| :|.:.:.:..
Mouse   253 RSSV----------------EILRVYLALH--SKLQ------------IHLCCG-DQSLGSTEIP 286

  Fly   423 LRAYIQ----ELNSLHEVVQE--------NELLRRKLHIPDDVV-IMAKNVHSKQRNKDKQIERL 474
            |...::    |:|. |.|..|        |...::...:|.|:. .:..:|..::...|.| ..:
Mouse   287 LNGLLKKGSTEINQ-HPVTVEGAFTLDPPNRAKQKLAPVPLDLAPTVGVSVALQREGIDSQ-SLI 349

  Fly   475 TLKLRTSEELRLQLKLEKSELRRKLLELQQDSPQTLNESLQAPSEVGEVPHSVHLENSPRRGQGD 539
            .||.:...|.....|...:.::.|.|    ..|::..||...|....:.|        |.:   |
Mouse   350 ELKTQNGHEAEHSQKRVLTPIKEKTL----TGPKSPRESPAPPPPPNQTP--------PTK---D 399

  Fly   540 GAASSEMQN-RYDEVLAENETLRSGMYEILEKLREYDAT---SEHITIDSDLLRRLIEALPGGTT 600
            .|..||::: :||:   :.:....|:..:...|.:.:||   ||.:|
Mouse   400 DATESEVESLQYDK---DPKPTVKGIGSVPASLAQPEATCGASEVVT------------------ 443

  Fly   601 TPQRLQGQLLELKAREEALRQLLEQQNYSDSETGELSSVHSLCEVPEIAEEHPVEEDAVLNTATR 665
                 .||.:.:.|                       :.|..|...::...|.:|....:|...|
Mouse   444 -----SGQKIAVPA-----------------------ASHHFCFSVDLRSVHDLELSFPVNCILR 480

  Fly   666 PSSPTEATMGLRRPTVPDPEEKPTNEALAELSILRKHYDELRLHMSADGSDLMNRNQELHDQMIA 730
            .|.|   ..|...|.:.:|..:           :||:. |:.|..|....|......:|.|..:.
Mouse   481 YSYP---FFGSAAPIMTNPPVE-----------VRKNM-EVFLPQSYCAFDFATMPHQLQDTFLR 530

  Fly   731 LELQLE------------------QQRNSYS-----YMRRDYDQLLTETRKQELRFIDDKASLAR 772
            :.|.:|                  |..|..|     ::..:.:|...:|..:.:..|..:.|..|
Mouse   531 IPLLVELWHKDKMSKDLLLGVARIQLSNILSSEKTRFLGANGEQCWRQTYSESVPVIAAQGSNNR 595

  Fly   773 QLEHSKSELCEAREELEQVNRRNLYTAEEQQ---------------------KLEHR-----NAI 811
            .|:.|.:   ...|:...|..|.::.:|..|                     ::|.|     .|.
Mouse   596 ILDLSYT---MTLEDYGLVKMREIFVSESSQGVPAVDQKPSSPPPAPCPSEIQMEPRETLEYKAA 657

  Fly   812 LSMQLGQAMEQLL--GELKPTEIC------------------------AEYGIIRENYQLDYITA 850
            |.:::.:.|::.:  .:||..|:.                        |||.|:....|.   ..
Mouse   658 LELEMWKEMQEDIFESQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYSILEGKLQK---AL 719

  Fly   851 QDFEEQQQELLTWRSKQAELQRETKQLEGLLHVANEQIHSQQRLLNEITDNHINLRHLVADLQSS 915
            .:.|.::|:|   .|.:||||||.|:|:          ..::|.|.|:.|:
Mouse   720 TELETREQQL---ASAEAELQRERKELQ----------LERERNLQELQDS-------------- 757

  Fly   916 SDEKLMLAKVQRDLDSVKAECSRLETEREKLQLKADCLQTQLEASELSLKQTQQD---FQQERTN 977
                     |:|..|                    ||:. |:|...|.|||.::|   .||:..:
Mouse   758 ---------VRRARD--------------------DCVY-QVELERLKLKQLEEDKQRLQQQLND 792

  Fly   978 SDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQRRLEEEQVQQRHRDHTALIDEVTAVV 1042
            :..|:|.|:......||                              ||.::....|..|:..:.
Mouse   793 AGNKYKTLEKEFQQFKD------------------------------QQNNKPEIRLQSEINLLT 827

  Fly  1043 QAKIGLNEESSQQLVKLIKSETQTRLLEQRCEILQAKQEELVRELGELRMSQATDTEHWSTIQAL 1107
            ..|:        :|.:.::|.|:::        |..||:                   |..
Mouse   828 LEKV--------ELERKLESATKSK--------LHYKQQ-------------------WGR---- 853

  Fly  1108 FGEGEPRSQLKVDAETNTDAVAPNLAMRRAVQLIDRESSPIGSPLRKHPHLDTATQTLEAQVEFS 1172
                                     |::...:|..||.....:.|:|.            |.|..
Mouse   854 -------------------------ALKELARLKQREQESQMARLKKQ------------QEELE 881

  Fly  1173 ETAVQTNGILSQQNQAVQTADAVEDNRRDSRAELQKMQETLQEANQRIEILGKQLEASRSESRES 1237
            :  ::...:.:::.:.|:|.   :....|.|.||.::::  ||.||       ..:.....|.:.
Mouse   882 Q--MRLRYLAAEEKETVRTE---QQELLDIRNELNRLRQ--QEQNQ-------YQDCKEIASGKL 932

  Fly  1238 ASPQGGVVEKTILSFHTLLLEKDQSIQK-----YQDLLQTERD-QSQQALSKQVA 1286
            .||:|..:|:.:..:.|.|:|:..::.:     ::|.:.:|.| |.::.|:|..|
Mouse   933 GSPRGSGLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREVLTKNSA 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cep290	NP_001261227.1	SMC_prok_B	208..>973	CDD:274008	157/880 (18%)
Cep120	NP_848801.2	C2	9..114	CDD:301316	20/73 (27%)
		DUF3668	118..340	CDD:289201	53/300 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..425		17/88 (19%)
		C2	<533..566	CDD:175973	5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..644		0/19 (0%)
		CEP63	667..920	CDD:293650	71/425 (17%)
		DASH_Spc19	<711..791	CDD:285487	31/139 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000