DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cep290 and Cep290

DIOPT Version :9

Sequence 1:	NP_001261227.1	Gene:	cep290 / 38099	FlyBaseID:	FBgn0035168	Length:	1978	Species:	Drosophila melanogaster
Sequence 2:	XP_006513589.1	Gene:	Cep290 / 216274	MGIID:	2384917	Length:	2756	Species:	Mus musculus

Alignment Length:	2744	Identity:	515/2744 - (18%)
Similarity:	983/2744 - (35%)	Gaps:	949/2744 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RQKQELYETLLELAE-SIDELPKKSLRKTLEL---TLAVLEYKGEQVQ-QLQESAAGGLSSDRRL 79
            ||::...:.|:.|:: .::||..:.....:.|   |.::::.|.::|: .|:|....|   :.:.
Mouse    20 RQEELADKLLISLSKVEVNELKNEDQENMIHLFRITQSLMKMKAQEVELALEEVEKAG---EEQA 81

  Fly    80 QDENEKLKRMLQKLEDERDGLKSKA-----KELGEEIRQLELRLQEAAQQAEISDKDSSDPLSEL 139
            :.||: ||..:.|||:|.:..:..|     :.|.:||||||       :|.|..|::..|...||
Mouse    82 KFENQ-LKTKVMKLENELEMAQQSAGGRDTRFLRDEIRQLE-------KQLEQKDRELEDMEKEL 138

  Fly   140 DKQ----EQL-LQNIDSKNKHIKRLLKEIETLQNQNIAQSKTIVLHEREL------------QTI 187
            ||:    ||| |:|.:::|::.| |.:|.|.|:...|...|.|...:..|            |..
Mouse   139 DKEKKVNEQLALRNEEAENENSK-LRRENEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLS 202

  Fly   188 KAN--LVQLSQDI-------TKVEQERKSLKQKEQQQALEITRL--------------EGNLTFL 229
            |.|  |||...:|       .|:|.:.:.:::..::...|:.::              :..:..:
Mouse   203 KKNYELVQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQI 267

  Fly   230 EVEREKQEVEMRQFLDKYEAKS--------------LGWRQALDDRDKEV---ERLKKQLEGKSI 277
            :.|.|...:::|:..|..:||.              ..|:..|..:|.|:   :::.:.|.|| :
Mouse   268 KKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGK-L 331

  Fly   278 SSGQTNSSNSQSQQEEEHAKLRQLLESREQRIEKLEEKIKSMAEEMVSSTRAM----NQLCQEKE 338
            .:.|.::..|...      .|:|.::.|:.:|:.|.|:::...:||..:|..:    |:|.::|.
Mouse   332 KNAQLDADKSNIM------ALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKG 390

  Fly   339 RAHDPEQP-----RACCQMIEERLREATARCQQLSEMLEAAEQDNVLKSQQALHAISALEAYKRD 398
            .::..:|.     .:..|::||:.:||    ::::|:.||..::   |.::.:.|:..|:.|:..
Mouse   391 TSNFYQQTHYMKIHSKVQILEEKTKEA----ERIAELAEADARE---KDKELVEALKRLKDYESG 448

  Fly   399 EDGLIPALRRCSGLEQKVAARDKQLRAYIQELNSL----HEVVQENELLRRKLHIPDDVVIMAKN 459
            ..||..|:......:.::..||.::....:|:|.|    ::::.|||.||.:..:....:|....
Mouse   449 VYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIDLTE 513

  Fly   460 VHSKQRNKDKQI----------------ERLTLK-----------------------LRTSEELR 485
            ..:.:|.|.:|.                |||.||                       |..||...
Mouse   514 FRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASGLTIDDLNLSETFS 578

  Fly   486 LQLKLE-------------------KSELRRKLLE-------LQQDSPQ---------------- 508
            .:.|:|                   ||..:.:||.       :|.|..:
Mouse   579 HENKIEGRKLNFMSLNNMNETQSKIKSSAKTELLHRRPSFSVVQSDQSEAEENMATRSLSRMLSG 643

  Fly   509 ----------------------------------TLNESLQAP--------------------SE 519
                                              |:.|..:||                    .|
Mouse   644 IHQSVGSAGDPIVSLTRCSSFMQVKDSSATPEAITIREIFKAPCLRSLRKLESLVSTFSKDGSEE 708

  Fly   520 VGE-------------------------------------------------------------- 522
            :.|
Mouse   709 LSEYLCSLSDDHMKRGSGNHRGLEKTRFLQKSSSSFQVSPAAAELMQKLSHRQSSAIFPQQSYDR 773

  Fly   523 ---------------VPHSVHLENSPRRGQGDGAASSEM-------------------------- 546
                           :.|:| |.....:||.:..:.:||
Mouse   774 DVDKVTSEDNQVYSQIEHAV-LSLKDDKGQSELPSQTEMLSSKTQVNLSDLVPITAQSKPSLIHP 837

  Fly   547 ----------------------------------------------------------------- 546

Mouse   838 LEKLIGQPQRQLAFLRSQNETIVQDLPIQEEQSRNAELELDHQRSQAEQNEFLSRELAEKEKDLE 902

  Fly   547 ---------QNRYDEVLAENETLRSGMYEILEKLREYDATSE------HITIDSDLLRRLIEAL- 595
                     |::..|::.||:.|..||.|||:.:::....|:      .:.|.|  |.||:.|:
Mouse   903 RSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPS--LERLVNAME 965

  Fly   596 ----PGGTTTPQRLQGQLLELKAREEALRQLLEQQ-----NYS-------------DSETGELSS 638
                .|.......|:.|:.:|..|.|.|||.|.|.     |||             :.||..|..
Mouse   966 SKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKETDLLRQ 1030

  Fly   639 --------------------------------VHSLCEVPE------------------------ 647
                                            :|.|.|:..
Mouse  1031 SAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRH 1095

  Fly   648 ----------------------IAE-----EHPVEEDAV-------LNTATRPSSPTEATM---G 675
                                  |.|     |...|:|||       |.:|.:..|.....|   .
Mouse  1096 QQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSEN 1160

  Fly   676 LRRPTVPDPEEKPTNEALAELSILRKHYD--ELRLHMSADGSDLMNRN----------------- 721
            .|:.||....||         |::|::..  |:..|:..:..  .:||
Mouse  1161 SRKITVLQVNEK---------SLIRQYTTLVEMERHLRKENG--KHRNDVIAMEAEVTEKLGSLQ 1214

  Fly   722 -------------QELHDQMIAL-ELQL-EQQRNSYSYMRRDY---DQLLTETRKQELRFID-DK 767
                         |::.|..::| ||:| .:|.|..:...||.   |.:|.: |...|..:: :.
Mouse  1215 RFKEMAIFKIAALQKVIDNSVSLSELELANKQYNELTTKYRDILQKDNMLVQ-RTSNLEHLECEN 1278

  Fly   768 ASLARQLEHSKSELCEAREELEQV-----------NRRNLYTAE--------------------- 800
            |||..|:|....||...:|:|..:           |..|:..|:
Mouse  1279 ASLKEQMEAISKELEITKEKLHTIEQAWEQETKLGNDSNMDKAKKSMTNSDIVSISKKITVLEMK 1343

  Fly   801 ---EQQKLEH--------RNAILSM-QLGQAMEQLLGELKPTEICAE--YGIIRENYQLDYITAQ 851
               |:|:.||        |.::..| :....:|....||....:.|:  ..::|:.. .|.:|..
Mouse  1344 ELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDEL-ADSVTKA 1407

  Fly   852 DFEEQQQELLTWRSKQAELQRETKQLEGLLHVANEQI---HSQQRLLNEITDNHINLRHLVADLQ 913
            ..:..:|.:|.....:.||:.|..:|..:..:|..|:   :|||:...:..:   :||..:.|.|
Mouse  1408 VSDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVE---SLRTQLLDFQ 1469

  Fly   914 SSSDEKLMLAKVQRDLDSVK----AECSRLETEREKLQLKADCLQTQLEASELSLKQTQQDFQQ- 973
            :.||||.::||:.:.:.|::    ....:||:...|||        ::||..|.|:|...:.:|
Mouse  1470 AQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQ--------KMEAYNLRLEQKLDEKEQA 1526

  Fly   974 ---ERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQRRL------------EEEQ 1023
               .|.....:.|.|:.::..|:.:::...||.       ..:||.:.:            |.:.
Mouse  1527 LYYARLEGRNRAKHLRQTIQSLRRQFSGALPLA-------QQEKFSKTMIQLQNDKLKIMQEMKN 1584

  Fly  1024 VQQRHRDHTALIDEVTAVVQAKI-GLNEESSQQLVKLIKS--------ETQTRLLEQRCEILQAK 1079
            .||.||:    ::..|..::.|: ||.|     |:..:|.        ....::.|.|.:.|:..
Mouse  1585 SQQEHRN----MENKTLELELKLKGLEE-----LISTLKDARGAQKVINWHVKIEELRLQELKLN 1640

  Fly  1080 QEELVRELGELRMSQATDTEHWSTIQALFGEGEPRSQLKVDAETNTDAVAPNLAMRRAVQLIDRE 1144
            : |||:...|::......:|:..||.:|  |.|...|.|...|.........:.:.|.:.:.|.:
Mouse  1641 R-ELVKGKEEIKYLNNIISEYEHTINSL--EEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQ 1702

  Fly  1145 SSPIGSPLRKHP----HLDTATQTLEAQVEFSETAVQTNGILSQQNQAVQTADAVEDNRRDSRAE 1205
            .:.|.|..:|..    .:...:..|..|:|.:...::.|..:..:.||  |..::|:..::..:.
Mouse  1703 QNEILSAAQKFEDSTGSMPDPSLPLPNQLEIALRKIKENIQVILKTQA--TCKSLEEKLKEKESA 1765

  Fly  1206 LQKMQETLQEANQRIEILGKQLEASRSE-------SRESASPQG----GVVEKTILSFHTLLLEK 1259
            |:..::.:...::.|..|..:|.|:...       .|:...|:.    .:..:||.:....|..|
Mouse  1766 LRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEPKSHHTMKIAHQTIANMQARLNHK 1830

  Fly  1260 DQSIQKYQDLLQTERDQSQQALSK-------------QVAEN--ESLRATVNNLNFNIKTKDAEI 1309
            ::.::|||.||:..|::.::.:.|             |.|:|  ...|.|..:|   :|...|.:
Mouse  1831 EEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDL---LKQSPAPV 1892

  Fly  1310 QGLKE--KLRQKPEVPVERNPSTDS-----RSSSSSDSSVNELTDEKIEELFESSSVERPPQEEL 1367
            ...|.  :|.:..:...|::.|..|     :..|.......|:|:.|:.| ||::.:..  ||
Mouse  1893 PTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVRE-FENTKLRL--QE-- 1952

  Fly  1368 EVPVEAGPENIVTEEPEGEEEKQDTEELKE-VPTLHKQIKDLKDKLE-----YSERSLKTREEEV 1426
                        |...|.::.|.:.|:|:. :...||..:.||.:|:     .|.....|....|
Mouse  1953 ------------THASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLV 2005

  Fly  1427 DILKEKLKLCQEREKSVESTVNPELDQLRIFLDEK------------------DKHIKDLMDTLK 1473
            |.||.:|.|.::::|::...:.....::....:|:                  ::|.::|...::
Mouse  2006 DRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIE 2070

  Fly  1474 NFHDDQQRYIKDTSNFSEDQIAKLAADLNRTEATNKIYHTQMEALRRQLANVTQREKQARDL-SQ 1537
            :.:::..: :|:....|:::...||.|||  |..|::...|      :..|...|||...|. :.
Mouse  2071 DLNENLLK-LKEALKTSKNKENSLADDLN--ELNNELQKKQ------KAYNKILREKDGIDQEND 2126

  Fly  1538 SLRQQLLKRPVVSIKTELNARVKNENQLKRIQQLELDLDEARGQLQRQQTLLEAKRTR---SANE 1599
            .||:| :||    :.:.|.::...:|:...|.:|:..:.:...||:|:...::.|..:   |..|
Mouse  2127 ELRRQ-IKR----LSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSSKEE 2186

  Fly  1600 VQLWEKQKRYQQQAEKTKARLEETELALEKTRALLQAARTTIARLEKDKQILESKLGRNGPPSNS 1664
            :..||:.|::|.:.|..:.||:|.|.........|...:...|:.:|:|..|:.||...|...:
Mouse  2187 LIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLKTTGMTVD- 2250

  Fly  1665 SGGNNLKCCRTPSCPNLQHVGVSKFAPSPSESPETYTGPSSECSSPAHHHTQIFDQSQLDL---- 1725
                             |.:|| :...|..|..|                   ..:..|||
Mouse  2251 -----------------QVLGV-RALESEKELEE-------------------LKKKNLDLENDI 2278

  Fly  1726 --------------IEALKSRIELQQRKIIAME---LEGRGSNALTTELEKLQERC---QAIEAQ 1770
                          :|.|..:.:..|.|:..:|   .:.:.|.:||:|:|. .:.|   |.::.:
Mouse  2279 LYMRTQQALPRDSVVEDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIES-DDHCQKEQELQKE 2342

  Fly  1771 NIRLEARNLQL-----QLDSDLLRQGDSSDRLQKRIKHLEDYIMALKEEMARNESRRELGSGLKV 1830
            |::|.:.|::|     |.:.||       .||:.::|.|::....||:  .:.|..|:||. ::.
Mouse  2343 NLKLSSENIELKFQLEQANKDL-------PRLKNQVKDLKEMCEFLKK--GKLELERKLGQ-VRG 2397

  Fly  1831 STNQGQS---AEQTILSLRNLVEKLRSENKFLKD------------------------------- 1861
            :...|::   .|:||..::.:|||::.||:.||.
Mouse  2398 AGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHF 2462

  Fly  1862 GRRST---ESRS-SMDSTPAEAARLQQQ---HAEALEKISALQQELQ----KRTTKCSQCGGRSK 1915
            ||:.:   ||:: ..:...||..||:::   ..||.||:...:..|:    |...:..:.|.|.:
Mouse  2463 GRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQ 2527

  Fly  1916 DAANE-----------------------ELKFIKEQLVKKTQLLQKAKVLLTRAAAKEKVLREQL 1957
            .|.:.                       ::|.::..:.||.|.:...|.|:..|..:|:..::..
Mouse  2528 FAESRAPQLEGADSKSWKSIVVSRVYETKMKELESDIAKKNQSITDLKQLVREATEREQKAKKYT 2592

  Fly  1958 ALWKRKCSELQNVP 1971
            ...:::...|:|||
Mouse  2593 EDLEQQIEILKNVP 2606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cep290	NP_001261227.1	SMC_prok_B	208..>973	CDD:274008	217/1333 (16%)
Cep290	XP_006513589.1	Smc	<112..461	CDD:224117	83/370 (22%)
		PRK05771	429..>557	CDD:235600	26/130 (20%)
		SMC_prok_B	<846..1553	CDD:274008	135/732 (18%)
		SMC_prok_B	1360..2135	CDD:274008	173/841 (21%)
		CEP209_CC5	1567..1694	CDD:374641	28/138 (20%)
		Smc	1918..2677	CDD:224117	156/769 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18879
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100