Protein Alignment cep290 and CEP120

DIOPT Version :9

• Sequence 1: NP_001261227.1
• Gene: cep290 / 38099
• FlyBaseID: FBgn0035168
• Length: 1978
• Species: Drosophila melanogaster
• Sequence 2: NP_001362334.1
• Gene: CEP120 / 153241
• HGNCID: 26690
• Length: 986
• Species: Homo sapiens
• Alignment Length: 1116
• Identity: 210/1116 - (18%)
• Similarity: 416/1116 - (37%)
• Gaps: 314/1116 - (28%)

  Fly   261 RDKEVERLKKQLEGKSISSGQTNSSNSQSQQEEEHAKLRQLLESR---EQRIEKLEEKIKSMAEE 322
            |.|.:..::.:.:|:.:::...:    .:.|.|...:|...::.:   :.|:::...|::..|.:
Human    23 RPKHMLVVEAKFDGEQLATDPVD----HTDQPEFATELAWEIDRKALHQHRLQRTPIKLQCFALD 83

  Fly   323 MVSSTR-AMNQLCQEKERAHDPEQPRACCQMIEERLREATARCQQLSEMLEAAEQDNVLKSQQAL 386
            .|:|.: .:..:..:...|.:.:|.....|::..:..:..:.. |:|..||.       .::..:
Human    84 PVTSAKETIGYIVLDLRTAQETKQAPKWYQLLSNKYTKFKSEI-QISIALET-------DTKPPV 140

  Fly   387 HAISALEAYKRDEDGLIPALRRCSGLEQKVAARDKQLRAYIQELNSLHEV--------------- 436
            .:..|..|..|  ||.:||:  .:||:      .:.:.|.:.|....|::
Human   141 DSFKAKGAPPR--DGKVPAI--LAGLD------PRDIVAVLNEEGGYHQIGPAEYCTDSFIMSVT 195

  Fly   437 ----VQENELLRRKLHIPDD-------VVIMAKNVHSKQ----RNKDKQIERLTLKLRTSEE--- 483
                .|..:|:...:.:|:.       ..::..:|.::.    .|.:.:.||.::::|:|.|
Human   196 IAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILR 260

  Fly   484 --LRLQLKLE-----------KSE------LRRKLLELQQ-----DSPQTLNESLQAPSEVGEVP 524
              |.||.||:           .:|      |::...|:.|     :...||:...:|..::..:|
Human   261 VYLALQSKLQIHLCCGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIP 325

  Fly   525 HSVHLENSPRRG-----QGDGAASSEM-----QNRYD------EVLA--ENETLRSGMYEILEKL 571
                :|.:|..|     |.:|..|..:     ||.::      :||.  :.:||.......:..:
Human   326 ----VELAPTVGVSVALQREGIDSQSLIELKTQNEHEPEHSKKKVLTPIKEKTLTGPKSPTVSPV 386

  Fly   572 REY--------DATS---EHITIDSDLLRRLIEALPGGTTTPQRLQGQLLELKAREE---ALRQL 622
            ..:        |||.   |.:..|.|             |.|..        ||...   :|.||
Human   387 PSHNQSPPTKDDATESEVESLQYDKD-------------TKPNP--------KASSSVPASLAQL 430

  Fly   623 LEQQNYSDSETGELSSV----HSLCEVPEIAEEHPVEEDAVLNTATRPSSPTEATMGLRRPTVPD 683
            :...|.|:..:|:..:|    |..|...::...|.:|....:|...|.|.|   ..|...|.:.:
Human   431 VTTSNASEVASGQKIAVPATSHHFCFSIDLRSIHALEIGFPINCILRYSYP---FFGSAAPIMTN 492

  Fly   684 PEEKPTNEALAELSILRKHYDELRLHMSADGSDLMNRNQELHDQMIALELQLEQQRNSYSYMRRD 748
            |..:           :||:. |:.|..|....|......:|.|..:.:.|.:|.....    :..
Human   493 PPVE-----------VRKNM-EVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKD----KMS 541

  Fly   749 YDQLLTETR--------KQELRFIDDKASLARQLEHSKSELCEAREELEQV--------NRR--- 794
            .|.||...|        .::.||:.           |..|.|..:...|.|        |.|
Human   542 KDLLLGIARIQLSNILSSEKTRFLG-----------SNGEQCWRQTYSESVPVIAAQGSNNRIAD 595

  Fly   795 --NLYTAEEQQKLEHRNAIL--SMQLGQAMEQLLGELK----PTEICAEYGIIRENYQLDYITAQ 851
              ...|.|:...::.|...:  |.|...|::|....|.    |:||..|   .||.  |:|..|.
Human   596 LSYTVTLEDYGLVKMREIFISDSSQGVSAVQQKPSSLPPAPCPSEIQTE---PRET--LEYKAAL 655

  Fly   852 DFE---EQQQELLTWRSKQAEL----------QRETKQLEGLLHVANEQIHSQQRLLNEITDNHI 903
            :.|   |.|:::...:.||.||          ::..::.|.|:          ::.:.|.|....
Human   656 ELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLV----------KKKVAEYTILEG 710

  Fly   904 NLRHLVADLQSSSDEKLMLAKVQRDLDSVKAECSRLETEREK----LQ-----LKADCLQTQLEA 959
            .|:..:.||:....:   ||.|:.:|...|.|   |::||::    ||     .|.||:. |:|.
Human   711 KLQKTLIDLEKREQQ---LASVESELQREKKE---LQSERQRNLQELQDSIRRAKEDCIH-QVEL 768

  Fly   960 SELSLKQTQQD---FQQERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQKFQRRLEE 1021
            ..|.:||.::|   .||:..:::.|:|.|:......||
Human   769 ERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKD--------------------------- 806

  Fly  1022 EQVQQRHRDHTALIDEVTAVVQAKIGLNEESSQQLVKLIKSETQTRL-LEQRC-----EILQAKQ 1080
               ||.::....|..|:..:...|:        :|.:.::|.|:::| .:|:.     |:.:.||
Human   807 ---QQNNKPEIRLQSEINLLTLEKV--------ELERKLESATKSKLHYKQQWGRALKELARLKQ 860

  Fly  1081 EELVRELGELRMSQATDTEHWSTIQALFGEGEPRSQLKVDAETNTDAVAPNLAMRRAVQLIDRES 1145
            .|...::..|:..|    |....::..:...|.:..:|.:.:...|.......:|:..|...::|
Human   861 REQESQMARLKKQQ----EELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDS 921

  Fly  1146 SPIGSPLRKHPHLDTATQTLE----AQVEFSETAVQTNGILSQQNQAVQTADAVEDNRRDSRAEL 1206
            :.|.|..:..||.....:.|:    ..:|..:|.::| |:.:.:::.:...|
Human   922 TEIASGKKDGPHGSVLEEGLDDYLTRLIEERDTLMRT-GVYNHEDRIISELD------------- 972

  Fly  1207 QKMQETLQEAN 1217
            ::::|.|.::|
Human   973 RQIREILAKSN 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cep290	NP_001261227.1	SMC_prok_B	208..>973	CDD:274008	167/860 (19%)
CEP120	NP_001362334.1	C2	9..114	CDD:387358	13/94 (14%)
		DUF3668	118..340	CDD:372096	42/243 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..424		16/94 (17%)
		Smc	<640..917	CDD:224117	71/340 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	914..937		6/22 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000