DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cep290 and Cep290

DIOPT Version :10

Sequence 1:NP_612064.1 Gene:Cep290 / 38099 FlyBaseID:FBgn0035168 Length:1978 Species:Drosophila melanogaster
Sequence 2:XP_313977.5 Gene:Cep290 / 1274776 VectorBaseID:AGAMI1_010779 Length:2094 Species:Anopheles gambiae


Alignment Length:2217 Identity:703/2217 - (31%)
Similarity:1137/2217 - (51%) Gaps:414/2217 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 LELAE-SID-ELPKKSLRKTLELTLAVLEYKGEQVQQLQESAAGGLSSDRRLQDENEKLKRMLQK 92
            ||:|. |.| :|..||.:|...|....|.::.|||:||:::...| ..|...|:..::.||.::|
Mosquito    24 LEIANLSTDVKLDSKSSKKLFRLAQVALRFRNEQVRQLKQTLVEG-KDDFGSQERMKEWKRTIEK 87

  Fly    93 LEDERDGLKSKAKELGEEIRQLELRLQEAAQQAEISDKDSSDPLSELDKQEQLLQNIDSKNKHIK 157
            ||.||..|::|.|::.||..:|:.:|.|...... ..:||.|.|||:::|::|..||..||||||
Mosquito    88 LELERHTLRTKLKDVMEENAKLQAKLAEGLHGGS-EGEDSPDALSEIERQQELYNNISMKNKHIK 151

  Fly   158 RLLKEIETLQNQNIAQSKTIVLHERELQTIKANLVQLSQDITKV------EQERKSLKQKEQQQA 216
            |||::|:.|:.:|..|..||...:..|.....|:..|:....::      :||..|...|:.|| 
Mosquito   152 RLLRDIDDLEKRNNFQVDTINGLQVSLNDATLNITALTHQYEELQARWSEQQELNSKLNKKLQQ- 215

  Fly   217 LEITRLEGNLTFLEVEREKQEVEMRQFLDKYEAKSLGWRQALDDRDKEVERLK-------KQLEG 274
                 :||.|..:..|:|..:.::.....::..:...|...:|.|:||:..||       .|..|
Mosquito   216 -----MEGELMGVCDEKENLQEQLNTTRTEHTNQVAEWEDQIDQREKELNELKIRYDDLLSQFPG 275

  Fly   275 KSISSGQTNSSNSQSQQEEEHAKLRQLLESREQRIEKLEEKIKSMAEEMVSSTRAMNQLCQEKER 339
            ..|.:           :..|:..:.:.||.:::.|..||:||.::::|:..||..||::.:||.|
Mosquito   276 IDIEA-----------ERREYKLMAERLEQKDEIIVDLEQKILTLSKEIHRSTEVMNRISEEKAR 329

  Fly   340 A-HDPEQPRACCQMIEERLREATARCQQLSEMLEAAEQDNVLKSQQALHAISALEAYKRDEDGLI 403
            | .:..|...|||....:|.:|..||:::.|:|...|.||.:||:||:.||.||..|:..|:||.
Mosquito   330 ASQEKRQESHCCQEYRMQLEKANERCREMQEILADVEDDNRVKSKQAVEAIEALRRYENGEEGLA 394

  Fly   404 PALRRCSGLEQKVAARDKQLRAYIQELNSLHEVVQENELLRRKLHIPDDVVIMAKNVHSKQRNKD 468
            .||::...|::||.:||||:|..|.|:|..:|:..||.:||::|.|.||.|:...::.:||:...
Mosquito   395 SALKKVHRLQEKVNSRDKQIRQLISEINLANEIAIENGVLRKRLGIEDDEVVATSSILAKQKKIA 459

  Fly   469 KQIERLTLKLRTSEELRLQLKLEKSELRRKLLELQQDSPQTLNESLQAPSEVGEVPHSVHLENSP 533
            |..|||.||||.|||:||||||||::|:|:|..|.|:..:..|.|.....:.|:.     |..||
Mosquito   460 KVNERLALKLRASEEMRLQLKLEKNDLKRQLAALAQNLKRQTNNSDVPDPDTGKT-----LPQSP 519

  Fly   534 RRGQ----GDGAAS--------------------------------------------------- 543
            .:|.    .|.|||                                                   
Mosquito   520 GKGSVADVDDLAASIDDVQVIKFCEKCMKQYNVYDSMKHCKACIFRHSFSYCDKCVGQLQMNFDE 584

  Fly   544 -------------------SEMQNRYDEVLAENETLRSGMYEILEKLREYDATSEHITIDSDLLR 589
                               .|::.:|..|:.|||.||.||:|||||||||||.|:.:|||.|.|.
Mosquito   585 DRPKGTSRSAETDANHHRIRELEQQYITVIEENENLREGMHEILEKLREYDAMSDRLTIDRDTLE 649

  Fly   590 RLIEAL-----PGGTTTPQRLQGQLLELKAREEALRQLLEQQNYSDSETGELSSVHSLCEVPEIA 649
            :|:..|     ..|..:..|....|| ..|||   |:||                        :.
Mosquito   650 KLLNVLSVRPMSVGWHSGMRFPNDLL-AAARE---RELL------------------------LK 686

  Fly   650 EEHPVEEDAVLNTATRPSSPTEATMGLRRPTVPDP----EEKPTNEALAELSILRKHYDELRLHM 710
            |...:..||..|  .|.|...::|     .:|.|.    .|...:|::..|...:..:.|..|..
Mosquito   687 ERLAIVVDADAN--GRISKSIQST-----ESVNDSGNVCNEDDNSESIERLEPEQIDFSEQVLLK 744

  Fly   711 SADGSDLMNRNQEL---HDQMIALELQLEQQRNSYSYM-------RRDYDQLLTETRKQELRFID 765
            :.:...||.:|::|   :::::|::.:|:..:..|:.|       ..:.|:||.:| ...||.|:
Mosquito   745 AVEIDRLMEKNEQLRVENERLLAVQDELQVTQKLYTEMLHITNASENEKDRLLVQT-VDRLRDIE 808

  Fly   766 D-KASLARQLEHSKSELCEAREELEQVNRRNLYTAEEQQKLEHRNAILSMQLGQA---------- 819
            . ..:|.|:::..|:|            ..||:.:..|.|:||.|.:..::|..|          
Mosquito   809 SGVCTLQRKVDFLKAE------------NDNLHNSLRQIKIEHLNLLHELRLQLATRSSELKQPE 861

  Fly   820 -----------------MEQLLGEL--KPTEICAEYGIIRENYQ--------------------- 844
                             :|:|..||  ..:|....|.|..:|.:                     
Mosquito   862 AIDGAKGDSFDSLDSDQIEKLESELMRMKSEATNIYNIFLKNIREVDKDHLLEVDYSKLNQLSIV 926

  Fly   845 -----LDYITAQDFEEQQQELLTWRSKQAELQRE---TKQLEGLLHVANEQIHSQQRLLNEITDN 901
                 ::::|..:::..:..|   ...:.|||||   :..||.||.|:||||.|||.|:::.::.
Mosquito   927 DNSLAVEFVTKDEYKRMKDRL---DGLERELQRELVKSGHLEELLKVSNEQIRSQQSLISKYSEE 988

  Fly   902 HINLRHLVADLQSSSDEKLMLAKVQRDLDSVKAECSRLETEREKLQLKADCLQTQLEASELSLK- 965
            .::|||||.||||:|:||.:||:..::|:.|:.:...|:.|..|::|  ..||...|...|.|: 
Mosquito   989 EVSLRHLVVDLQSASNEKYLLARANKELELVREQEENLKLENSKMKL--TLLQKLEELDNLKLRH 1051

  Fly   966 -QTQQDFQQERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNFVFAYQK---FQRRLEEEQVQQ 1026
             |.:|:|..|:.::.:|.:||:.||.:|...:..:.|...:..|:..|.|   .:..|.|||.:.
Mosquito  1052 DQQRQEFSAEQRDNKLKIRFLKKSLQLLTIGHHSYLPTSAIPEFIKMYTKALELRESLTEEQRKY 1116

  Fly  1027 RHRDHTALIDEVTAVVQAKIGLNEESS--QQLVKLIKSETQTRLLEQRCEILQAKQEELVRELGE 1089
            :|:    :.||....:.||:..|.|.:  |..:.|||.|:|:..|.::..:.|.:.::|.||..:
Mosquito  1117 QHQ----MRDEEYERIFAKLKENLEGNHIQDKINLIKYESQSEYLTRQLILCQEQVDQLQRENKQ 1177

  Fly  1090 LRMSQATDTEHWSTIQALFGEGEPRSQ----------LKVDAETNTDAVAPNLAMRRAVQLIDRE 1144
            |||.:...|.||.|::.||||...||:          ::|..||::..:       ..:.:|:  
Mosquito  1178 LRMKEIDYTRHWDTLELLFGEEAQRSRQDRDKYFDKAVQVAVETSSKCI-------NTIPIIE-- 1233

  Fly  1145 SSPIGSPLRKHPHLDTATQTLEAQVEFSETAVQTN-------------GILSQQNQAVQTADAVE 1196
             ..:|...|:....||.:. .:.:.|.|:|....|             .:.||..||:..|..  
Mosquito  1234 -DTLGEGPRRCSSGDTISD-FDGRSEHSQTGAHVNEQIAVTVHTVAQRSLESQLKQAMMLAST-- 1294

  Fly  1197 DNRRDSRAELQKMQETLQEANQRIEILGKQLEASRSESRESA-SP--------QGGVVEKTILSF 1252
                 ..|.|.:.:..|.|...||::|.|.||...|..:|.| ||        :..::..||.|.
Mosquito  1295 -----RSALLLEAESRLSECQGRIKLLEKSLEEKESLLKEQAQSPSVAKHDRVEDSILSTTIGSL 1354

  Fly  1253 HTLLLEKDQSIQKYQDLLQTERDQSQQALSKQVAENESLRATVNNLNFNIKTKDAE--------- 1308
            ..||||||.::.:||:||::||.:..|...:.:|:..:|:.|:::|...:..|..|         
Mosquito  1355 QNLLLEKDTTLSRYQELLKSERSEHSQVYDENMAQIRNLKKTIDDLEQKLYEKQKECDNIATQLN 1419

  Fly  1309 ----IQGLKEKLRQKPEVPVERNPSTDSRSSSSSDSSVNELTDEKIEELFESSSVERPPQEELEV 1369
                ::.|:|.:.:||. .||     |..::.|||:...:.||:.||.::|....:....::|.|
Mosquito  1420 DMNRLKALQESVPEKPR-SVE-----DEAATGSSDAGAIDYTDKIIENIYEIDEKKEREIQDLNV 1478

  Fly  1370 PVEAGPENIVTEEPEGEEEKQDTEELKEVPTLHKQIKDLKDKLEYSERSLKTREEEVDILKEKL- 1433
            .|:....|:  :|.|.|:::           |..|::|...:.:.||:.|:.:|.|:..|.::| 
Mosquito  1479 QVKMLERNV--QELENEQKR-----------LQLQLRDANAREKKSEKLLREKEMELVALNDRLT 1530

  Fly  1434 KLCQEREKSVESTVN-PELDQLRIFLDEKDKHIKDLMDTLKNFHDDQQRYIKDTSNFSEDQIAKL 1497
            |...:..:..|:..: .|::||:..|:|||:||:||.:||..||:||:.::.|||..|.:|:::|
Mosquito  1531 KETHDLREFTETIASAQEIEQLKEMLEEKDRHIQDLTETLSQFHEDQRSFMNDTSLHSAEQVSQL 1595

  Fly  1498 AADLNRTEATNKIYHTQMEALRRQLANVTQREKQARDLSQSLRQQLLKRPVVSIKTELNARVKNE 1562
            :|||||:||:|::..||:|||:||:.::.|||||:|||.::|:.||:||||:::|.:..:..:.:
Mosquito  1596 SADLNRSEASNRVLKTQIEALKRQIVSIQQREKQSRDLVKTLKNQLIKRPVIAMKADRMSTPRED 1660

  Fly  1563 NQLKRIQQLELDLDEARGQLQRQQTLLEAKRTRSANEVQLWEKQKRYQQQAEKTKARLEETELAL 1627
            :..:|:||||.:|.:.:.:|::|..:.|.:|.::|.|:.||.||||:||.||:.|.:|:|.|:.|
Mosquito  1661 HLARRVQQLETELLDTKDELRKQTAINENRRAKTAAELDLWNKQKRWQQMAERLKVQLKEREVEL 1725

  Fly  1628 EKTRALLQAARTTIARLEKDKQILESKLGRNGPPSNSSGGNNLKCCRTPSCPNLQHVGVSKFAPS 1692
            ||.:.....|:|||||||:|:..|.|....:|.|::...                    :|:  .
Mosquito  1726 EKLKVHFNTAKTTIARLERDRTRLNSAGTGSGAPASLLD--------------------NKY--Q 1768

  Fly  1693 PSESPETY-TGPSSECSSPAHHHTQIFDQSQLDLIEALKSRIELQQRKIIAMELEGRGSNALTTE 1756
            ||.||:.| :..|:|....:...||:|.|:..::|||||||||.|||:||||||:.:|||.:..|
Mosquito  1769 PSGSPDQYCSTDSTESEDTSTITTQMFTQNSKEIIEALKSRIESQQRRIIAMELDRKGSNTVAHE 1833

  Fly  1757 LEKLQERCQAIEAQNIRLEARNLQLQLDSDLLRQGDSSDRLQKRIKHLEDYIMALKEEMARNE-- 1819
            |||:||:...:||||:||||:.||||||:|:|||.|.|:||:::|||||:|::|||||:|:..  
Mosquito  1834 LEKMQEKLCNMEAQNVRLEAKTLQLQLDNDMLRQSDESERLKRQIKHLEEYVIALKEEIAKATAG 1898

  Fly  1820 --------------SRRELGSGLKVSTNQGQSAEQTILSLRNLVEKLRSENKFLKD--GRRSTES 1868
                          |||   ||......:..:.|||:|:|:.::||||:|||.||:  .|....|
Mosquito  1899 CPESINFENLCVRCSRR---SGTNDLAERNANLEQTVLTLKRMIEKLRAENKHLKEHRNRERAAS 1960

  Fly  1869 RSSMDSTPAEAA------RLQQQH-------AEALEKISALQQELQ-KRTTKCSQC--------- 1910
            ..|:.:.|.|..      ||:::|       .:||.|:|..|.|:: ..:.:|::|         
Mosquito  1961 AESLANPPNETIAKELYDRLKKEHEKMQQNLTDALNKVSVQQVEIELLSSVRCTRCKVSAGAAGS 2025

  Fly  1911 GGRSK----DAANEELKFIKEQLVKKTQLLQKAKVLLTRAAAKEKVLREQLALWKRKCSELQNVP 1971
            ||.::    ..|:|||   :::|.||:|||:|||:||.||||||:.|:||:.|.:||||:|||||
Mosquito  2026 GGPNRADTATGADEEL---RDKLEKKSQLLEKAKILLQRAAAKERYLKEQIDLLRRKCSDLQNVP 2087

  Fly  1972 VIDEISE 1978
            |||||||
Mosquito  2088 VIDEISE 2094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cep290NP_612064.1 Smc <11..>524 CDD:440809 177/509 (35%)
SMC_prok_B <839..>1092 CDD:274008 83/288 (29%)
Smc <854..>1413 CDD:440809 172/613 (28%)
GumC <1477..>1655 CDD:442439 79/177 (45%)
YhaN 1492..>1899 CDD:443752 180/438 (41%)
Cep290XP_313977.5 None

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