Protein Alignment cep290 and cep290

DIOPT Version :9

• Sequence 1: NP_001261227.1
• Gene: cep290 / 38099
• FlyBaseID: FBgn0035168
• Length: 1978
• Species: Drosophila melanogaster
• Sequence 2: XP_031754760.1
• Gene: cep290 / 100144438
• XenbaseID: XB-GENE-1221198
• Length: 2457
• Species: Xenopus tropicalis
• Alignment Length: 2429
• Identity: 479/2429 - (19%)
• Similarity: 962/2429 - (39%)
• Gaps: 672/2429 - (27%)

  Fly    27 ETLLELAESID--ELPKKSLRKTLELTLAVLEYKGEQVQQLQESAAGGLSSDRRLQDENEKLKRM 89
            :|.:.:.:|.|  :.|.::|.:...::..:::.|.::||.|.|.|.  .:::.:|:.||: |:..
 Frog    29 QTTISMVKSTDIKDEPNENLIQLFRISQCLMKLKAQEVQLLLEEAE--KANEEQLKTENQ-LRNR 90

  Fly    90 LQKLEDERD--GLKSKAKE---LGEEIRQLELRLQEAAQQAEISDKDSSDPLSELDKQEQLLQNI 149
            :::||:|.:  .|.|.:::   |.|||||||.:|::       |:::..|..:||::::|:.:.:
 Frog    91 VKRLENEIEVAQLSSGSRDSRFLREEIRQLEEQLRQ-------SERECKDMANELEREKQVNEQL 148

  Fly   150 -------DSKNKHIKRLLKEI---------------ETLQNQNIAQSKTIVLHERELQTIK---- 188
                   |::|..::|..:::               |||.:::..|....:|.::.::.:|
 Frog   149 ALRNEETDNENSKLRRENEQLRQDVIDYQRQIDSQRETLMSRSRGQDYKSLLSQKNMELVKYLDE 213

  Fly   189 --------ANLVQLSQDITK-VE---QERKSLKQKEQQQALEITRLEGNLTFLEVEREKQEVEMR 241
                    ..|...:|::|| :|   ||.:.:..:..:..|.:...:..:..|..|:|:..::::
 Frog   214 IQSLSETNEKLEAQNQELTKHLEYSVQEMEKMTDEYNKMKLMVQNSDSTMDRLRKEKEQHRLQVQ 278

  Fly   242 QFLDKYEAKSL--------------GWRQALDDRDKEVERLKKQLEG--KSISSGQTNSSNSQSQ 290
            :..::.:||:.              .|:..|..:|:|:...:|::..  :.:...|.::..|..
 Frog   279 ELAEQLKAKNEEDDPVMRAVNAKVDEWKIILASKDEEISDYQKKIVDLREKLKIAQLDADKSSV- 342

  Fly   291 QEEEHAKLRQLLESREQRIEKLEEKIKSMAEEMVSST----RAMNQLCQEKE-----RAHDPEQP 346
                 ..|:|.|:.|...|:.|.||::...:||.|:|    :...||..||.     .....|:.
 Frog   343 -----LALQQALQERNNHIKMLTEKLEQHTQEMESNTFHIEKLKLQLQTEKGVSGHIEIKQAEEL 402

  Fly   347 RACCQMIEERLREATARCQQLSEMLEAAEQDNVLKSQQALHAISALEAYKRDEDGLIPALRRCSG 411
            .....::|||::|:       ..:.:.||.|...|.::.:.|:..:..|:....||:.|:.....
 Frog   403 VGMLNILEERVKES-------ERIAKLAESDAREKDKELVEALRRMREYEAGVYGLVEAVSEIKE 460

  Fly   412 LEQKVAARDKQLRAYIQELN----SLHEVVQENELLRRKLHI-PDDVVIMA--KNVHSKQRNKDK 469
            |:.::..||:::.:.|::||    .|::::.|||.|:::|.: |...:.:.  ||:.:.:..:.:
 Frog   461 LKTQIKIRDQEIESLIKDLNKHHLKLNDILDENEELKQRLGLDPKTAIDLTEFKNIKALKEQQYR 525

  Fly   470 QIERLTLK-LRTSEELRLQLKLEKSELRRKL-------------LELQQDSPQTLNESLQAPSEV 520
            ...::.|| :...||.|::||.:..:|.::.             |.|..|||:......:.||
 Frog   526 AENQVLLKEVECLEEERIRLKKQIRKLAQEKGKRAACLGLTADDLNLSVDSPEDHKSKKKKPS-- 588

  Fly   521 GEVPHSVHLENSPRRGQGDGAASSEMQ---NRYDEVLAENETLRSGMYEI------LEKL----- 571
                :|:.|:::....:......||.:   .||..:.||   |:|.:.||      ||::
 Frog   589 ----NSIVLDHAEGMNEHLSKQLSEKEQELERYKTITAE---LKSKLKEISEDKKHLEQIPKDIF 646

  Fly   572 -------REYDATSEHITIDSDLLRRLIEALPGGTT-----TPQRLQGQLLELKAREEALRQ--- 621
                   :::....|...|....|.|||.|:....|     ....|:.|:.:|..|.|.|||
 Frog   647 QALKDVEKDHTRNGEATIISVPSLERLIHAIESRNTEGIFDVSIHLKAQVDQLTGRNEELRQELK 711

  Fly   622 -----------LLEQQN-------------------------------YSDSETGELSS-----V 639
                       .||:.|                               .|.:.|..|:|     :
 Frog   712 ESRKEAINISCALEKANEKILHLENELEMLRQLEGANMIFKPINLPDGMSPTSTNLLNSLNEYIL 776

  Fly   640 HSLCEVPEIAEEHPVEEDAVLNTATRPSSPTEATMGL---------------------------- 676
            |.|.|| |..|:..::.:..|....|..:......||
 Frog   777 HLLQEV-ESKEQSVIKFEEALEEYKRKFAVIRHQHGLLYKEYMSEQESWQEELKKLKEENAKLEN 840

  Fly   677 RRPT-----------------VPDPEEKPTNEALAELSILR-------KHYD---ELRLHMSADG 714
            ::.|                 .||..:|...|.|.::::||       :.|.   |:..|:..|.
 Frog   841 QKETDMVQIKEYTNLLDALKMDPDEMKKQVAENLRKMTVLRVNEKLLTRRYTTLLEMEQHLRKDN 905

  Fly   715 SDLMNRNQEL-------------HDQMIALEL--------------QLEQQRNSYSYMRRDY--- 749
            ..|.|...::             :.::.|.::              :||.....|:.:...|
 Frog   906 GKLKNDISDMEAAVAERLGYLQRYKEIAAFKIASLQRALDDSVPISELETANKQYNELTSKYRDM 970

  Fly   750 ---DQLLTETRKQELRFID-DKASLARQLEHSKSEL------CEARE------------------ 786
               |.||.: |..::..:: :.|||..|:.....||      |...|
 Frog   971 LQKDNLLVQ-RTADMEHLEHENASLKSQIAFYNKELEITKEKCNTLEQALEHINNLDGNPAMDKA 1034

  Fly   787 -------------------ELEQVNRRNLYTAEEQQKL-EHRNAILSMQLGQ---AMEQLLGELK 828
                               |::::|.|.  .||..||: ||....|: ||.:   .:|....||
 Frog  1035 TKAITNNEIVSISKKITMLEMKELNERQ--RAEHSQKMYEHLRTTLT-QLEERNFELETKFAEL- 1095

  Fly   829 PTEICAEYGIIRENYQLDY---ITAQDFEEQQQELLTWRSKQAELQRETKQLEGLLHVANEQIHS 890
             |:|..|...:.:..:.|.   ::....:..::.::.....:|||:.|..:|..:..:|..|:.:
 Frog  1096 -TKINLEAQKVEQALRDDLANSVSKAVSDADRKRIMELEKTEAELKAEMSKLRNVSDIAKMQVSA 1159

  Fly   891 ----QQRLLNEITDNHINLRHLVADLQSSSDEKLMLAKVQRDLDSVKAECS----RLETEREKLQ 947
                ||....|:.    ::|..:.|.|..||||.::||:.:.:.:::...|    :||....||:
 Frog  1160 LASRQQSREKEVE----SMRKQILDYQDQSDEKALIAKLHQQIVALQISESTAVGKLEAATAKLR 1220

  Fly   948 LKADCLQTQLEASELSLKQTQQDFQQ----ERTNSDIKHKFLQHSLFMLKDKYAKFTPLVFLTNF 1008
                    ::||..|.|:|...|..|    .|.....:.|.|:.::..|:.:::...||.
 Frog  1221 --------KMEAYNLRLEQKIDDKDQALYYARMEGRNRAKHLRQTVHSLRRQFSGALPLA----- 1272

  Fly  1009 VFAYQKFQRRL------------EEEQVQQRHRD---HTALIDEVTAVVQAKIGLNEESSQQLVK 1058
              ..:||.:.:            |.|:|||..|:   |:           .::.|..:..::|:.
 Frog  1273 --QQEKFSKTMMQLQNDKLKTIHEMERVQQERREAENHS-----------VELELKLKGLEELIS 1324

  Fly  1059 LIK--------SETQTRLLEQRCEILQAKQEELVRELGELRMSQATDTEHWSTIQALFGEGEPRS 1115
            .:|        :|...|:.|.|.:.|:..: ||.::..|::......:|...||..|  |.:...
 Frog  1325 TLKDARGAQKVTEWHRRIEELRLQDLKLSR-ELSQKKEEIKYLNNMISEQERTISIL--EEDLVQ 1386

  Fly  1116 QLKVDAETNTDAVAPNLAMRRAVQLIDRESSPIGSPLRKH---------------PHLDTATQTL 1165
            |.|...|.........:.:.|.:.:.:.:.:.:.|..:|.               ..|:.|.:.:
 Frog  1387 QGKFHEERQMSWDQREVELERQLDMYEHQQNEVLSAAQKFEEATGEVPDSNLPLPEQLEIALRKI 1451

  Fly  1166 EAQVEFSETAVQTNGI-------LSQQNQAVQTADAVEDN--RRDSRAELQKMQETLQEANQRIE 1221
            :..|   :..|:|..:       |.:::..::||   |:|  .||......::|.....|.   |
 Frog  1452 KEHV---KAVVETKSVCRTLEEKLKEKDSLLRTA---ENNILSRDRVINELRLQLPATAAK---E 1507

  Fly  1222 ILGKQLEASRSESRESASPQGGVVEKTILSFHTLLLEKDQSIQKYQDLLQTERDQSQQALSKQVA 1286
            .|...|...:.:|.:..:.:  |..:|:.:....|.:|::.::|||.||...|::.::...|..
 Frog  1508 TLLSNLNQIKEDSEQHQALK--VAHQTVANMQARLNQKEEMLKKYQHLLAKAREEQEEVTKKHA- 1569

  Fly  1287 ENESLRATVNNLNFNIKTKDAEIQGLKEKLRQ---KP--EVP----------VERNPSTDSRSSS 1336
              |.|:...:.|||   ..|..|...||..::   ||  ::|          :|:..:....|.:
 Frog  1570 --EDLKELHHKLNF---YSDTSINNFKEAAKEFMKKPSLQIPSSANLIRLAEMEQTVAEQENSLA 1629

  Fly  1337 SSDSSVNELTDE----------KIEELFESSSVERPPQEELEVPVEAGPENIVTEEPEGEEEKQD 1391
            |..:.:.:.|.|          |:.| ||:|......:..:|:                ::.|.|
 Frog  1630 SLSNQLRKATSELEKQKQITIAKVNE-FENSKTRLEEKHIVEI----------------KKLKND 1677

  Fly  1392 TEELK-EVPTLHKQIKDLKDKLEYSERSLKTR------EEEVDILKEKLKLCQEREK-------- 1441
            .|:|: .:....|:|..|..:|| :::...||      :..|:.||.::.|.:::::
 Frog  1678 AEDLRARIAETEKEINYLNTELE-AQKEANTRAPTSTMKNLVERLKNQVALKEKQQQALSKALLT 1741

  Fly  1442 ------------------------SVESTVNPELDQLRIFLDEKDKHIKDLMDTLKNFHDDQQRY 1482
                                    :|:..|:.|...|:..:::.::....|.:.|||....:...
 Frog  1742 LRAEMTSQAEQHIIAAAAQKEENINVQQIVDKETKDLKARIEKLNEQQLKLKEALKNSKSRENAL 1806

  Fly  1483 IKDTSNFSED------QIAKLAADLNRTEATNKIYHTQMEALRRQLANVTQREKQARDLSQSLRQ 1541
            |::..|.::|      .::||..|.:..|..|       |.|::::.::|...:...||.
 Frog  1807 IEEAENLNQDLRGKEKALSKLQKDKDEMERDN-------EELKKRIKDLTINFQGKVDLH----- 1859

  Fly  1542 QLLKRPVVSIKTELNARVKNENQLKRIQQLELDLDEARGQLQRQQTLLEAKRTRSANEVQLWEKQ 1606
                          |....:|:..:||::||.:|.:...:.:|:....:..   |..|:..||:.
 Frog  1860 --------------NKHNTSEDLQRRIKKLEAELAKKSEEAERKPVRDDKS---SKEEIIRWEES 1907

  Fly  1607 KRYQQQAEKTKARLEETELALEKTRALLQAARTTIARLEKDKQILESKLGRNGPPSNSSGGNNLK 1671
            |::|.:.|..:::|::.|..::.....|...:...::.|::|.:|:.||...|...:...|
 Frog  1908 KKWQIKIEGMRSKLKDKEKEVDSLTKQLTTLKDLYSKGEQEKLMLQKKLKSRGVTVDQVVG---- 1968

  Fly  1672 CCRTPSCP---------------NLQHVGVSKFAPSPSESPETYTGPSSECSSPAHHHTQIFDQS 1721
             .||....               .:||:...:..|..|...:.             |....|.|.
 Frog  1969 -ARTAESEREVEELRKKNQELENEIQHMKTKQALPRDSVIDDL-------------HLKNRFLQE 2019

  Fly  1722 QLDLIEALKSRIELQQRKIIAMELEGRGSNALTTELEKLQERCQAIEAQNIRLEARNLQLQLDSD 1786
            :|..:|.     :|.|.........|.||:..|.||||          :|::|.:.|::||..
 Frog  2020 KLQALER-----QLSQENTSRPSTSGLGSDDQTRELEK----------ENLKLTSENVELQFH-- 2067

  Fly  1787 LLRQGDSS-DRLQKRIKHLEDYIMALKEEMARNESRRELGSGLKVSTNQGQSA---EQTILSLRN 1847
             |.|.:.. .||:.:|::|::....||:|  :.|:.|::.| ::.|...|::.   |:||..::.
 Frog  2068 -LEQANKDLPRLKDQIENLKEMCDLLKKE--KIEAERKVAS-VRGSGRSGKTVPELEKTIALMKR 2128

  Fly  1848 LVEKLRSENKFLK--DGRRSTESRSSM----DSTPAEAARLQ-----------QQHAEALEKISA 1895
            :||:::.||:.||  .|..|.|..:::    :....|..:||           :...:.:||:.|
 Frog  2129 VVERVQKENEELKKAPGIVSNEKLTNLEMENEKLKLEIEKLQLHVGGQLSMRYEAKTKGIEKLIA 2193

  Fly  1896 ----LQQELQKRTTKCSQCGGRSKDAANEELKFIKEQLVKKTQLLQKAKVLLTR----------- 1945
                |::|| |..|:.|:    ....|...|:.|||:|.:.   |::|::.::.
 Frog  2194 ENDRLRKEL-KTETETSE----KLRIAKRNLEVIKEKLARD---LEEARMNISERSGPQLEGTQG 2250

  Fly  1946 AAAKEKVLREQLALWKRKCSELQN 1969
            .|.|..|:.:   :::.|..||::
 Frog  2251 KAWKSTVVSK---MFENKIKELES 2271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cep290	NP_001261227.1	SMC_prok_B	208..>973	CDD:274008	200/1033 (19%)
cep290	XP_031754760.1	Smc	64..860	CDD:224117	214/1099 (19%)
		pneumo_PspA	793..>1146	CDD:411490	84/394 (21%)
		SMC_prok_B	1163..1993	CDD:274008	190/939 (20%)
		CEP209_CC5	1280..1407	CDD:406877	29/152 (19%)
		Smc	1613..2406	CDD:224117	89/410 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4742
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3647
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19529at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18879
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.160