DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JMJD5 and KDM8

DIOPT Version :9

Sequence 1:	NP_612063.2	Gene:	JMJD5 / 38097	FlyBaseID:	FBgn0035166	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_001138820.1	Gene:	KDM8 / 79831	HGNCID:	25840	Length:	454	Species:	Homo sapiens

Alignment Length:	418	Identity:	154/418 - (36%)
Similarity:	216/418 - (51%)	Gaps:	49/418 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTQLLPR-----WVDL-ENVVRGEVEARYILKRAADHLANLRSGGDSGAEETGYLVGALVDRNWE 66
            |..|||.     .:|| |.|.|..|.   :|:||.:.....|......:.|      .::|.:||
Human    60 LRALLPHSKEDLKLDLGEKVERSVVT---LLQRATELFYEGRRDECLQSSE------VILDYSWE 115

  Fly    67 RIHTGHFSQVPLVTRKIYAIACCFKIFFLLLESTSPAQKDACSEILDEAQLLGCMEDWSELKVAL 131
            :::||.:..|....|::|||.|..|...|...........|...:.|...|:|.        ..|
Human   116 KLNTGTWQDVDKDWRRVYAIGCLLKALCLCQAPEDANTVAAALRVCDMGLLMGA--------AIL 172

  Fly   132 MDYLDKDGAVALNSAP--------LPTLEPLTR-----------VTSNCDIPQLDAPSLEEFQTK 177
            .|.|.|..|:.....|        ||. :|.|:           |.....:|:|..|||:.|:.:
Human   173 GDILLKVAAILQTHLPGKRPARGSLPE-QPCTKKARADHGLIPDVKLEKTVPRLHRPSLQHFREQ 236

  Fly   178 CFEAGQPTLLLNTIQHWPALHKWLDLNYLLQVAGNRTVPIEIGSNYASDEWSQQLVKIRDFLSRQ 242
            ....|:|.:|.....|||.:.|| .|.|:.::||.||||:|:||.|..:||||.|:.:.:|:|:.
Human   237 FLVPGRPVILKGVADHWPCMQKW-SLEYIQEIAGCRTVPVEVGSRYTDEEWSQTLMTVNEFISKY 300

  Fly   243 FGKEPSKAGQNIEYLAQHELFAQIPALKEDISIPDYCTISNEDTPGAVDIKAWLGPAGTVSPMHY 307
            ...||...|    |||||:||.|||.||:||||||||::.:.:.. .:.|.||.||.||:||:|.
Human   301 IVNEPRDVG----YLAQHQLFDQIPELKQDISIPDYCSLGDGEEE-EITINAWFGPQGTISPLHQ 360

  Fly   308 DPKHNLLCQVFGSKRIILAAPADTDNLYPHDSEFLANTARIDAAQLDPETYPLVAKVKFYQLLLQ 372
            ||:.|.|.||.|.|.|.|.:|.::..|||||:..|.||:::|....|.|.:|..||..|...:|.
Human   361 DPQQNFLVQVMGRKYIRLYSPQESGALYPHDTHLLHNTSQVDVENPDLEKFPKFAKAPFLSCILS 425

  Fly   373 PGDCLYMPPKWWHYVRSEAPSFSVSFWW 400
            ||:.|::|.|:|||||:...||||||||
Human   426 PGEILFIPVKYWHYVRALDLSFSVSFWW 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD5	NP_612063.2	Cupin_8	172..401	CDD:290351	106/229 (46%)
KDM8	NP_001138820.1	Cupin_8	233..454	CDD:290351	106/227 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160459
Domainoid	1	1.000	229	1.000	Domainoid score	I2483
eggNOG	1	0.900	-	-		E1_KOG2132
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49791
Inparanoid	1	1.050	258	1.000	Inparanoid score	I3149
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55837
OrthoDB	1	1.010	-	-		D1385616at2759
OrthoFinder	1	1.000	-	-		FOG0005789
OrthoInspector	1	1.000	-	-		oto91170
orthoMCL	1	0.900	-	-		OOG6_103632
Panther	1	1.100	-	-	LDO	PTHR12461
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3673
SonicParanoid	1	1.000	-	-		X4765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800