DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JMJD5 and Kdm8

DIOPT Version :9

Sequence 1:	NP_612063.2	Gene:	JMJD5 / 38097	FlyBaseID:	FBgn0035166	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_084118.1	Gene:	Kdm8 / 77035	MGIID:	1924285	Length:	414	Species:	Mus musculus

Alignment Length:	428	Identity:	151/428 - (35%)
Similarity:	214/428 - (50%)	Gaps:	66/428 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ELTQLLP-----RWVDLENVVRGEVEARYILKRAADHLANLRSGGDSGAEETGYLVG------AL 60
            ||..|||     ..:||...|...|.|  :|::|.            |....|:..|      |:
Mouse    18 ELRTLLPDKEEELKLDLGEKVDRSVAA--LLRQAV------------GLFYAGHWQGCLQASEAV 68

  Fly    61 VDRNWERIHTGHFSQVPLVTRKIYAIACCFKIFFLLLESTSPAQKDACSEIL---DEAQLLGCME 122
            :|.:||:::||.:..|....|::|:..|..|...|   ..:|.:.....|.|   |...|:|.
Mouse    69 LDYSWEKLNTGPWRDVDKEWRRVYSFGCLLKALCL---CQAPQKATTVVEALRVCDMGLLMGA-- 128

  Fly   123 DWSELKVALMDYLDKDGAVALNSAPLPTLEPL--------TRVTSNCD------------IPQLD 167
                  ..|.|.|.|..|| |.:..||..:|.        ....:.||            :|:|.
Mouse   129 ------AILEDILLKVVAV-LQTHQLPGKQPARGPHQDQPATKKAKCDASPAPDVMLERMVPRLR 186

  Fly   168 APSLEEFQTKCFEAGQPTLLLNTIQHWPALHKWLDLNYLLQVAGNRTVPIEIGSNYASDEWSQQL 232
            .|.|:.|:......|:|.:|.....|||.:.|| .|.|:.::||.||||:|:||.|..::|||.|
Mouse   187 CPPLQYFKQHFLVPGRPVILEGVADHWPCMKKW-SLQYIQEIAGCRTVPVEVGSRYTDEDWSQTL 250

  Fly   233 VKIRDFLSRQFGKEPSKAGQNIEYLAQHELFAQIPALKEDISIPDYCTISNEDTPGAVDIKAWLG 297
            :.:.:|:.:....|....|    |||||:||.|||.||.||||||||.:.|.:.. .:.|.||.|
Mouse   251 MTVDEFIQKFILSEAKDVG----YLAQHQLFDQIPELKRDISIPDYCCLGNGEEE-EITINAWFG 310

  Fly   298 PAGTVSPMHYDPKHNLLCQVFGSKRIILAAPADTDNLYPHDSEFLANTARIDAAQLDPETYPLVA 362
            |.||:||:|.||:.|.|.||.|.|.|.|.:|.:::.:|||::..|.||:::|....|.|.:|...
Mouse   311 PQGTISPLHQDPQQNFLVQVLGRKYIRLYSPQESEAVYPHETHILHNTSQVDVENPDLEKFPKFT 375

  Fly   363 KVKFYQLLLQPGDCLYMPPKWWHYVRSEAPSFSVSFWW 400
            :..|...:|.|||.|::|.|:||||||...||||||||
Mouse   376 EAPFLSCILSPGDTLFIPAKYWHYVRSLDLSFSVSFWW 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD5	NP_612063.2	Cupin_8	172..401	CDD:290351	102/229 (45%)
Kdm8	NP_084118.1	Interaction with RCCD1. /evidence=ECO:0000250\|UniProtKB:Q8N371	1..107		27/105 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..169		2/20 (10%)
		Cupin_8	189..414	CDD:290351	103/231 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850806
Domainoid	1	1.000	219	1.000	Domainoid score	I2634
eggNOG	1	0.900	-	-		E1_KOG2132
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49791
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3295
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55837
OrthoDB	1	1.010	-	-		D1385616at2759
OrthoFinder	1	1.000	-	-		FOG0005789
OrthoInspector	1	1.000	-	-		oto94754
orthoMCL	1	0.900	-	-		OOG6_103632
Panther	1	1.100	-	-	LDO	PTHR12461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4765
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770