Protein Alignment JMJD5 and Kdm8

DIOPT Version :10

• Sequence 1: NP_612063.2
• Gene: JMJD5 / 38097
• FlyBaseID: FBgn0035166
• Length: 401
• Species: Drosophila melanogaster
• Sequence 2: NP_084118.1
• Gene: Kdm8 / 77035
• MGIID: 1924285
• Length: 414
• Species: Mus musculus
• Alignment Length: 428
• Identity: 151/428 - (35%)
• Similarity: 214/428 - (50%)
• Gaps: 66/428 - (15%)

  Fly     7 ELTQLLP-----RWVDLENVVRGEVEARYILKRAADHLANLRSGGDSGAEETGYLVG------AL 60
            ||..|||     ..:||...|...|.|  :|::|.            |....|:..|      |:
Mouse    18 ELRTLLPDKEEELKLDLGEKVDRSVAA--LLRQAV------------GLFYAGHWQGCLQASEAV 68

  Fly    61 VDRNWERIHTGHFSQVPLVTRKIYAIACCFKIFFLLLESTSPAQKDACSEIL---DEAQLLGCME 122
            :|.:||:::||.:..|....|::|:..|..|...|   ..:|.:.....|.|   |...|:|.
Mouse    69 LDYSWEKLNTGPWRDVDKEWRRVYSFGCLLKALCL---CQAPQKATTVVEALRVCDMGLLMGA-- 128

  Fly   123 DWSELKVALMDYLDKDGAVALNSAPLPTLEPL--------TRVTSNCD------------IPQLD 167
                  ..|.|.|.|..|| |.:..||..:|.        ....:.||            :|:|.
Mouse   129 ------AILEDILLKVVAV-LQTHQLPGKQPARGPHQDQPATKKAKCDASPAPDVMLERMVPRLR 186

  Fly   168 APSLEEFQTKCFEAGQPTLLLNTIQHWPALHKWLDLNYLLQVAGNRTVPIEIGSNYASDEWSQQL 232
            .|.|:.|:......|:|.:|.....|||.:.|| .|.|:.::||.||||:|:||.|..::|||.|
Mouse   187 CPPLQYFKQHFLVPGRPVILEGVADHWPCMKKW-SLQYIQEIAGCRTVPVEVGSRYTDEDWSQTL 250

  Fly   233 VKIRDFLSRQFGKEPSKAGQNIEYLAQHELFAQIPALKEDISIPDYCTISNEDTPGAVDIKAWLG 297
            :.:.:|:.:....|....|    |||||:||.|||.||.||||||||.:.|.:.. .:.|.||.|
Mouse   251 MTVDEFIQKFILSEAKDVG----YLAQHQLFDQIPELKRDISIPDYCCLGNGEEE-EITINAWFG 310

  Fly   298 PAGTVSPMHYDPKHNLLCQVFGSKRIILAAPADTDNLYPHDSEFLANTARIDAAQLDPETYPLVA 362
            |.||:||:|.||:.|.|.||.|.|.|.|.:|.:::.:|||::..|.||:::|....|.|.:|...
Mouse   311 PQGTISPLHQDPQQNFLVQVLGRKYIRLYSPQESEAVYPHETHILHNTSQVDVENPDLEKFPKFT 375

  Fly   363 KVKFYQLLLQPGDCLYMPPKWWHYVRSEAPSFSVSFWW 400
            :..|...:|.|||.|::|.|:||||||...||||||||
Mouse   376 EAPFLSCILSPGDTLFIPAKYWHYVRSLDLSFSVSFWW 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JMJD5	NP_612063.2	Cupin_8	172..401	CDD:463936	102/229 (45%)
Kdm8	NP_084118.1	Interaction with RCCD1. /evidence=ECO:0000250|UniProtKB:Q8N371	1..107		27/105 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	148..169		2/20 (10%)
		Cupin_8	189..414	CDD:463936	103/231 (45%)