DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JMJD5 and Kdm8

DIOPT Version :9

Sequence 1:	NP_612063.2	Gene:	JMJD5 / 38097	FlyBaseID:	FBgn0035166	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_001032273.1	Gene:	Kdm8 / 308976	RGDID:	1304823	Length:	414	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	136/365 - (37%)
Similarity:	198/365 - (54%)	Gaps:	41/365 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ALVDRNWERIHTGHFSQVPLVTRKIYAIACCFKIFFLLLESTSPAQKDACSEIL---DEAQLLGC 120
            |::|.:||:::||.:..|....|::|:..|..|...|   ..:|.:..|.:|.|   |...|:|.
  Rat    67 AVLDYSWEKLNTGPWRDVDKEWRRVYSFGCLLKTLCL---CQAPQKATAVAEALRVCDMGLLMGA 128

  Fly   121 MEDWSELKVALMDYLDKDGAVALNSAPLPTL---------EPLTR-----------VTSNCDIPQ 165
                    ..|.|.|.| .|..|.:..||..         :|.|:           |..:.::|:
  Rat   129 --------AILGDILLK-VATVLQTHLLPRKQPACGPHQDQPATKKAKHDASSTPDVVLDREVPR 184

  Fly   166 LDAPSLEEFQTKCFEAGQPTLLLNTIQHWPALHKWLDLNYLLQVAGNRTVPIEIGSNYASDEWSQ 230
            |..|.|:.|:......|:|.:|.....|||.:.|| .|.|:.::||.||||:|:||.|..::|||
  Rat   185 LRCPPLQHFKKHFLVPGRPVILEGVADHWPCMKKW-SLQYIQEIAGCRTVPVEVGSRYTDEDWSQ 248

  Fly   231 QLVKIRDFLSRQFGKEPSKAGQNIEYLAQHELFAQIPALKEDISIPDYCTISNEDTPGAVDIKAW 295
            .|:.:.:|:.:....|....|    |||||:||.|||.||:||||||||.:.|.:.. .:.|.||
  Rat   249 TLMTVNEFIHKYILSEAKDVG----YLAQHQLFDQIPELKQDISIPDYCCLGNGEEE-EITINAW 308

  Fly   296 LGPAGTVSPMHYDPKHNLLCQVFGSKRIILAAPADTDNLYPHDSEFLANTARIDAAQLDPETYPL 360
            .||.||:||:|.||:.|.|.||.|.|.|.|.:|.:::.:|||::..|.||:::|....|.|.:|.
  Rat   309 FGPQGTISPLHQDPQQNFLVQVLGRKYIRLYSPQESEAVYPHETHILHNTSQVDVENPDLEKFPK 373

  Fly   361 VAKVKFYQLLLQPGDCLYMPPKWWHYVRSEAPSFSVSFWW 400
            ..:..|...:|.|||.|::|.|:||||||...||||||||
  Rat   374 FTEAPFLSCILSPGDTLFIPAKYWHYVRSLDLSFSVSFWW 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD5	NP_612063.2	Cupin_8	172..401	CDD:290351	102/229 (45%)
Kdm8	NP_001032273.1	Interaction with RCCD1. /evidence=ECO:0000250\|UniProtKB:Q8N371	1..107		12/42 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..173		2/20 (10%)
		Cupin_8	189..414	CDD:290351	103/231 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354523
Domainoid	1	1.000	221	1.000	Domainoid score	I2523
eggNOG	1	0.900	-	-		E1_KOG2132
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49791
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3203
OMA	1	1.010	-	-		QHG55837
OrthoDB	1	1.010	-	-		D1385616at2759
OrthoFinder	1	1.000	-	-		FOG0005789
OrthoInspector	1	1.000	-	-		oto98257
orthoMCL	1	0.900	-	-		OOG6_103632
Panther	1	1.100	-	-	LDO	PTHR12461
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4765
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770