DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42553 and RGD1308147

DIOPT Version :9

Sequence 1:	NP_612060.2	Gene:	CG42553 / 38094	FlyBaseID:	FBgn0260755	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_001014032.1	Gene:	RGD1308147 / 307008	RGDID:	1308147	Length:	421	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	135/402 - (33%)
Similarity:	211/402 - (52%)	Gaps:	48/402 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AHKKVKLGEELKKALKDFEDLPGVSKVQRKIQQELKFLNKVITTR-SVKEHHITSSNFVYYDFLI 77
            |.:.:|..|.|.::.|.  .:.|.:|:..|::.|||||.|:.:.: ::||.|:.|:|..:...::
  Rat    14 AKELIKRAESLSRSKKG--GIEGGAKLCSKLKSELKFLQKIESGKVAIKESHLQSTNLTHLKAIV 76

  Fly    78 KTLRLQQGVVDINAVFRLE---SRDSPLRVDIVANNGLKWVKVIARNSKSVEDAARGCVSIGARS 139
            ::....:.||.:..||...   .....|.||:|||.|..|||.|.|.::::.:...|....|.:|
  Rat    77 ESAENLEEVVSVLRVFGYTDSLGEKQTLVVDVVANGGHTWVKAIGRKAEALHNIWLGRGQYGDKS 141

  Fly   140 VIDQAEDYLEASELSFCMFQRPKIVFYFSNKIEDSLHEELMEMGVQ--------TASLDSPD--- 193
            :|:||||:|:||......:..|.|||.|.|.:...:.::|.:||:.        .:.|:.|:
  Rat   142 IIEQAEDFLQASRQQPVQYSNPHIVFAFYNSVSSPMADKLKDMGISVRGDIVAVNSLLNHPEEYL 206

  Fly   194 ------------------TDLD-----------MYATTSNELNLDVTTLLAYVSALTNGSANWVY 229
                              .|||           :.......:|||:|||:.||||::.|..::::
  Rat   207 LSESESDDEGQELLQVTRVDLDNVLARVAFPTEIKVDVCRRVNLDITTLITYVSAMSYGGCHFIF 271

  Fly   230 KEPLLTEQAERERASPLKPLLEKILEGKTLVCCQLAYDAFQSILDIVGGEGERKRAEELMKRVTV 294
            ||.:||||||:||...:.|.||..::.|.|..|:.|...||||||.:||.|||:||..|:||:.|
  Rat   272 KEKVLTEQAEQERKERVLPQLEAFMKDKELFACESAVKDFQSILDTLGGPGERERAAVLIKRINV 336

  Fly   295 YPDVETIPEEFSHIRFTANVNERSLKIFSFGMARQIFTVTSNKAFVRSAKMQGINVPVFVHASVA 359
            .||..:  |....:..::.:|.|||.||..|...:..|:|:|..|||:|..||:...||:|...|
  Rat   337 VPDQPS--ERALKLVASSKINSRSLTIFGTGDTLKAITMTANSGFVRAANNQGVKFSVFIHQPRA 399

  Fly   360 LTEGKQATGRPL 371
            |||.|:|...||
  Rat   400 LTESKEALAVPL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42553	NP_612060.2	DUF1308	41..361	CDD:284430	121/363 (33%)
RGD1308147	NP_001014032.1	DUF1308	38..401	CDD:284430	121/364 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353837
Domainoid	1	1.000	139	1.000	Domainoid score	I4704
eggNOG	1	0.900	-	-		E1_KOG4529
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11439
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3563
OMA	1	1.010	-	-		QHG52563
OrthoDB	1	1.010	-	-		D1139278at2759
OrthoFinder	1	1.000	-	-		FOG0006171
OrthoInspector	1	1.000	-	-		oto95955
orthoMCL	1	0.900	-	-		OOG6_106746
Panther	1	1.100	-	-	LDO	PTHR13379
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5894
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770