DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b3 and Cpsf160

DIOPT Version :9

Sequence 1:	NP_728546.1	Gene:	Sf3b3 / 38093	FlyBaseID:	FBgn0035162	Length:	1227	Species:	Drosophila melanogaster
Sequence 2:	NP_995833.1	Gene:	Cpsf160 / 44250	FlyBaseID:	FBgn0024698	Length:	1455	Species:	Drosophila melanogaster

Alignment Length:	1557	Identity:	288/1557 - (18%)
Similarity:	544/1557 - (34%)	Gaps:	482/1557 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATGVTHAVHGNFSGGKQQEVLLSRGKSLELLRPDSNTG------------------KVHTLLSTE 57
            ||.|..::...|.....:.::::....|::.|...|..                  ::..|.:..
  Fly    11 ATAVEFSIACRFFNNLDENLVVAGANVLKVYRIAPNVEASQRQKLNPSEMRLAPKMRLECLATYT 75

  Fly    58 IFGCVRALMAFRLTGGTKDYIVVGSDSGRIVILEYNPSKNALEKVHQETFGKSGCRRIVPGQYFA 122
            ::|.|.:|....|.|..:|.:::.....::.:|:::|...||:.:....|.:...|....|:||.
  Fly    76 LYGNVMSLQCVSLAGAMRDALLISFKDAKLSVLQHDPDTFALKTLSLHYFEEDDIRGGWTGRYFV 140

  Fly   123 ----IDPKGRAVMIGAVEKQKLAYIMNRDT---QARLTISSPLE----AHKSNT--LTYHMVG-- 172
                :||..|..::....|:.:.....:|.   :..|....|::    |..|.|  :..:::.
  Fly   141 PTVRVDPDSRCAVMLVYGKRLVVLPFRKDNSLDEIELADVKPIKKAPTAMVSRTPIMASYLIALR 205

  Fly   173 -VDVGFDNPMFACLEIDYEEADMDPSGDAAQRTQQTLTFYE------------------LDLGLN 218
             :|...||    .|:|.:.....:|:         .|..||                  :.:.||
  Fly   206 DLDEKIDN----VLDIQFLHGYYEPT---------LLILYEPVRTCPGRIKVRSDTCVLVAISLN 257

  Fly   219 HVVRKYSEPLEEHANFL---------VSVPGGNDGPSGVLICSENYLTYKN---------LGDQH 265
              :::...|:....|.|         :..|.|     |.|:.:.|.:.|.|         |....
  Fly   258 --IQQRVHPIIWTVNSLPFDCLQVYPIQKPIG-----GCLVMTVNAVIYLNQSVPPYGVSLNSSA 315

  Fly   266 DIRCPIPRRRNDLDDPERGM-IFICSATHRTKSMYFFLLQTEQGDIFKITLETDDDVVSEIKLKY 329
            |.....|.:      |:.|: |.:..|......:...::....||::.:||..|.  :..::..:
  Fly   316 DNSTAFPLK------PQDGVRISLDCANFAFIDVDKLVISLRTGDLYVLTLCVDS--MRTVRNFH 372

  Fly   330 FDTVPPA---TAMCVLKTGFLFVASEFGNHYL----------------------YQIAHLGDDDD 369
            |.....:   :.:|||.:.::|:.|..||..|                      .|..:|.|:|.
  Fly   373 FHKAAASVLTSCICVLHSEYIFLGSRLGNSLLLHFTEEDQSTVITLDEVEQQSEQQQRNLQDEDQ 437

  Fly   370 E-------------PEFSSAMPLEEGETFFFAPRALKNLV--------LVDELPSFAPI------ 407
            .             |..:.:..:|:.|...:...|..:::        :.|.|.:.|||
  Fly   438 NLEEIFDVDQLEMAPTQAKSRRIEDEELEVYGSGAKASVLQLRKFIFEVCDSLMNVAPINYMCAG 502

  Fly   408 ---------IT-----SQVADLANEDTPQLYVLCGRGPRSTLRVLRHGLEVSEMAVSELPGNPNA 458
                     :|     ..:.||..|    |....|......|.|..:.:....:...||.|..:
  Fly   503 ERVEFEEDGVTLRPHAESLQDLKIE----LVAATGHSKNGALSVFVNCINPQIITSFELDGCLD- 562

  Fly   459 VWTV------KKRADDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLCCAALGDDA-L 516
            ||||      |...:|:.| ::::|..|:||||..|:.:.|:.::||....||:....||... :
  Fly   563 VWTVFDDATKKSSRNDQHD-FMLLSQRNSTLVLQTGQEINEIENTGFTVNQPTIFVGNLGQQRFI 626

  Fly   517 VQVYPDGIRHIR------------------------SDKRV--------------NEWKAPGKKS 543
            |||   ..||:|                        :|..|              .|.:...:.:
  Fly   627 VQV---TTRHVRLLQGTRLIQNVPIDVGSPVVQVSIADPYVCLRVLNGQVITLALRETRGTPRLA 688

  Fly   544 ITKCAVNQRQVVITLSG--------------------------------------------RELV 564
            |.|..::....|:.:|.                                            .:|:
  Fly   689 INKHTISSSPAVVAISAYKDLSGLFTVKGDDINLTGSSNSAFGHSFGGYMKAEPNMKVEDEEDLL 753

  Fly   565 Y------FEMDPTGELNEYTER--SEMPAEIMCMALGTVPEGEQRSWFLAVGLADNTVRILSL-- 619
            |      |:|:...:|.:.:::  |:....::..|        :.|::|.|.....|:.|.|:
  Fly   754 YGDAGSAFKMNSMADLAKQSKQKNSDWWRRLLVQA--------KPSYWLVVARQSGTLEIYSMPD 810

  Fly   620 --------DPNN---CLTPCSMQALPSPAESLCLVEMGHTESTTQGGLDDDAPAQRSGNNKGTIY 673
                    |..|   .||. :|:.:|     :.|.    |:..::.|:......|.: |:...:.
  Fly   811 MKLVYLVNDVGNGSMVLTD-AMEFVP-----ISLT----TQENSKAGIVQACMPQHA-NSPLPLE 864

  Fly   674 LN-IGLS-NG----VLLRT----------------------------VLD--PVSGDLADT---- 698
            |: |||. ||    :|:||                            :||  |...||.:.
  Fly   865 LSVIGLGLNGERPLLLVRTRVELLIYQVFRYPKGHLKIRFRKMDQLNLLDQQPTHIDLDENDEQE 929

  Fly   699 -------RTRYLGS-RPVKLFRIKMQGSEAVLAMSSR---TWLSYYHQNRFHLTPLSYETLEYAS 752
                   :.:|:.. ||.    ..:.|...|:.....   .:|::..:.|.|....:.:...:|:
  Fly   930 EIESYQMQPKYVQKLRPF----ANVGGLSGVMVCGVNPCFVFLTFRGELRIHRLLGNGDVRSFAA 990

  Fly   753 GFSSEQCSEGIVAISTN-TLRILALE---KLGAVFNQVAFPLQYTPRTFVIHPDTGRM--LIAET 811
             |::.....|.:...|. .|:|..|.   ...:|:.....||:.|||..|.|.: .|:  ||.:|
  Fly   991 -FNNVNIPNGFLYFDTTYELKISVLPSYLSYDSVWPVRKVPLRCTPRQLVYHRE-NRVYCLITQT 1053

  Fly   812 DHNAYTEDTKSARKEQMAEEMRSAAGDEERELARE-MANAFINEVLP--EDVFSSPKAGLGLWAS 873
            :             |.|.:..|  ...|::||:.| ....||..:..  |.|..||:.    |..
  Fly  1054 E-------------EPMTKYYR--FNGEDKELSEESRGERFIYPIGSQFEMVLISPET----WEI 1099

  Fly   874 QIRCLDAMHGQTMFSVPLTQNEAIMSMAMLKFSIAADG-----RYYLAVGIAKDLQLNPRISQGG 933
               ..||       |:.....|.:.:..::|.|.  :|     :.||.:|  .:...:..|:..|
  Fly  1100 ---VPDA-------SITFEPWEHVTAFKIVKLSY--EGTRSGLKEYLCIG--TNFNYSEDITSRG 1150

  Fly   934 CIDIYKI-----DPTCSSLEFMHRTDIDEI--------PGALCGFQGRLLAGCGRMLRIYDFGKK 985
            .|.||.|     :|.....:|    .|.||        ..|:....|.|:.|.|:.:.|:.....
  Fly  1151 NIHIYDIIEVVPEPGKPMTKF----KIKEIFKKEQKGPVSAISDVLGFLVTGLGQKIYIWQLRDG 1211

  Fly   986 KMLRKC---ENKHIPYQIVNIQAMGHRVYVSDVQESVFFIRYRRAENQLIIFADDTHPRWVTATT 1047
            .::...   .|.:: :||:.::::   ::::||.:|:..:|::.....|.:.:.|.:|..|....
  Fly  1212 DLIGVAFIDTNIYV-HQIITVKSL---IFIADVYKSISLLRFQEEYRTLSLASRDFNPLEVYGIE 1272

  Fly  1048 -LLDYDTIA--IADKFGNLSIQRLPHSVTDDVDEDPTGTKSLWDRGLLSGASQKSENICSFHVGE 1109
             ::|...:.  :.|...|:.:...          .|...:||..:.||..|        .:|:|:
  Fly  1273 FMVDNSNLGFLVTDAERNIIVYMY----------QPEARESLGGQKLLRKA--------DYHLGQ 1319

  Fly  1110 IIMSL-----------QKATLIPGGSEALIYATLSGTVGAFVPFTSREDYDFFQHLEMHMRNENP 1163
            ::.::           |:...:......::|.||.|.:|..:|...:. |..|..|:..:.:...
  Fly  1320 VVNTMFRVQCHQKGLHQRQPFLYENKHFVVYGTLDGALGYCLPLPEKV-YRRFLMLQNVLLSYQE 1383

  Fly  1164 PLCGRDHLSYRS-------SYYPVKNVLDGDLCEQYLSI------EAAKQ-----KSIAGDM 1207
            .|||.:...||:       ...|.:.::||||...|..:      |.||:     :.|.||:
  Fly  1384 HLCGLNPKEYRTLKSSKKQGINPSRCIIDGDLIWSYRLMANSERNEVAKKIGTRTEEILGDL 1445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b3	NP_728546.1	MMS1_N	76..592	CDD:402179	126/731 (17%)
Sf3b3	NP_728546.1	CPSF_A	872..1194	CDD:397339	70/363 (19%)
Cpsf160	NP_995833.1	SFT1	1..1453	CDD:227490	288/1557 (18%)
		MMS1_N	94..674	CDD:287414	115/616 (19%)
		CPSF_A	1086..1419	CDD:281209	74/377 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10644
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940