DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b3 and SF3B3

DIOPT Version :9

Sequence 1:	NP_728546.1	Gene:	Sf3b3 / 38093	FlyBaseID:	FBgn0035162	Length:	1227	Species:	Drosophila melanogaster
Sequence 2:	NP_036558.3	Gene:	SF3B3 / 23450	HGNCID:	10770	Length:	1217	Species:	Homo sapiens

Alignment Length:	1227	Identity:	922/1227 - (75%)
Similarity:	1065/1227 - (86%)	Gaps:	10/1227 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYLYNLTLQKATGVTHAVHGNFSGGKQQEVLLSRGKSLELLRPDSNTGKVHTLLSTEIFGCVRAL 65
            |:|||||||:|||::.|:||||||.||||:::||||.|||||||.|||||||||:.|:||.:|:|
Human     1 MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSL 65

  Fly    66 MAFRLTGGTKDYIVVGSDSGRIVILEYNPSKNALEKVHQETFGKSGCRRIVPGQYFAIDPKGRAV 130
            |||||||||||||||||||||||||||.||||..||:|||||||||||||||||:.|:|||||||
Human    66 MAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAV 130

  Fly   131 MIGAVEKQKLAYIMNRDTQARLTISSPLEAHKSNTLTYHMVGVDVGFDNPMFACLEIDYEEADMD 195
            ||.|:|||||.||:|||..|||||||||||||:|||.||:|||||||:||||||||:||||||.|
Human   131 MISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADND 195

  Fly   196 PSGDAAQRTQQTLTFYELDLGLNHVVRKYSEPLEEHANFLVSVPGGNDGPSGVLICSENYLTYKN 260
            |:|:||..||||||||||||||||||||||||||||.|||::||||:|||||||||||||:||||
Human   196 PTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKN 260

  Fly   261 LGDQHDIRCPIPRRRNDLDDPERGMIFICSATHRTKSMYFFLLQTEQGDIFKITLETDDDVVSEI 325
            .|||.||||||||||||||||||||||:|||||:||||:|||.|||||||||||||||:|:|:||
Human   261 FGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEI 325

  Fly   326 KLKYFDTVPPATAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDDEPEFSSAMPLEEGETFFFAPR 390
            :||||||||.|.|||||||||||||||||||||||||||||||:|||||||||||||:||||.||
Human   326 RLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPR 390

  Fly   391 ALKNLVLVDELPSFAPIITSQVADLANEDTPQLYVLCGRGPRSTLRVLRHGLEVSEMAVSELPGN 455
            .||||||||||.|.:||:..|:|||||||||||||.|||||||:|||||||||||||||||||||
Human   391 PLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGN 455

  Fly   456 PNAVWTVKKRADDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLCCAALGDDALVQVY 520
            |||||||::..:|||||||||||||||||||||||||||||||||||||||.|:.||||||||||
Human   456 PNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVY 520

  Fly   521 PDGIRHIRSDKRVNEWKAPGKKSITKCAVNQRQVVITLSGRELVYFEMDPTGELNEYTERSEMPA 585
            ||||||||:||||||||.||||:|.|||||||||||.|:|.|||||||||:|:|||||||.||.|
Human   521 PDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSA 585

  Fly   586 EIMCMALGTVPEGEQRSWFLAVGLADNTVRILSLDPNNCLTPCSMQALPSPAESLCLVEMGHTES 650
            :::||:|..||.|||||.||||||.||||||:||||::||.|.||||||:..||||:||||.||.
Human   586 DVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEK 650

  Fly   651 TTQGGLDDDAPAQRSGNNKGTIYLNIGLSNGVLLRTVLDPVSGDLADTRTRYLGSRPVKLFRIKM 715
            ..:.|         ...:.|.:||||||.||||||||||||:|||:||||||||||||||||::|
Human   651 QDELG---------ERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRM 706

  Fly   716 QGSEAVLAMSSRTWLSYYHQNRFHLTPLSYETLEYASGFSSEQCSEGIVAISTNTLRILALEKLG 780
            ||.|||||||||:||||.:|:|||||||||||||:||||:||||.||||||||||||||||||||
Human   707 QGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLG 771

  Fly   781 AVFNQVAFPLQYTPRTFVIHPDTGRMLIAETDHNAYTEDTKSARKEQMAEEMRSAAGDEERELAR 845
            |||||||||||||||.|||||::..::|.|||||||||.||:.||:||||||..|||::|||||.
Human   772 AVFNQVAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAA 836

  Fly   846 EMANAFINEVLPEDVFSSPKAGLGLWASQIRCLDAMHGQTMFSVPLTQNEAIMSMAMLKFSIAAD 910
            |||.||:||.|||.:|.:||||.|.|||.||.::.:.|.|:..|.|.||||..|:|:.:||...:
Human   837 EMAAAFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGE 901

  Fly   911 GRYYLAVGIAKDLQLNPRISQGGCIDIYKIDPTCSSLEFMHRTDIDEIPGALCGFQGRLLAGCGR 975
            . :|:.||:||||.||||...||.:..||:......|||:|:|.::|:|.|:..||||:|.|.|:
Human   902 D-WYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGK 965

  Fly   976 MLRIYDFGKKKMLRKCENKHIPYQIVNIQAMGHRVYVSDVQESVFFIRYRRAENQLIIFADDTHP 1040
            :||:||.||||:|||||||||...|..||.:||||.|||||||..::||:|.|||||||||||:|
Human   966 LLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYP 1030

  Fly  1041 RWVTATTLLDYDTIAIADKFGNLSIQRLPHSVTDDVDEDPTGTKSLWDRGLLSGASQKSENICSF 1105
            ||||..:||||||:|.||||||:.:.|||.:..|:|||||||.|:|||||||:|||||:|.|.::
Human  1031 RWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNY 1095

  Fly  1106 HVGEIIMSLQKATLIPGGSEALIYATLSGTVGAFVPFTSREDYDFFQHLEMHMRNENPPLCGRDH 1170
            ||||.::||||.||||||||:|:|.||||.:|..|||||.||:|||||:|||:|:|:||||||||
Human  1096 HVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEMHLRSEHPPLCGRDH 1160

  Fly  1171 LSYRSSYYPVKNVLDGDLCEQYLSIEAAKQKSIAGDMFRTPNQICKKLEDIRTRYAF 1227
            ||:||.|:|||||:|||||||:.|:|..|||:::.::.|||.::.||||||||||||
Human  1161 LSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEVSKKLEDIRTRYAF 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b3	NP_728546.1	MMS1_N	76..592	CDD:402179	440/515 (85%)
Sf3b3	NP_728546.1	CPSF_A	872..1194	CDD:397339	200/321 (62%)
SF3B3	NP_036558.3	MMS1_N	76..592	CDD:402179	440/515 (85%)
		Interaction with PHF5A, SF3B1 and SF3B5. /evidence=ECO:0000269\|PubMed:27720643	105..119		13/13 (100%)
		Interaction with PHF5A, SF3B1 and SF3B5. /evidence=ECO:0000269\|PubMed:27720643	145..168		19/22 (86%)
		Interaction with SF3B1 and SF3B5. /evidence=ECO:0000269\|PubMed:27720643	193..231		32/37 (86%)
		Interaction with SF3B1 and SF3B5. /evidence=ECO:0000269\|PubMed:27720643	786..804		9/17 (53%)
		CPSF_A	863..1182	CDD:397339	199/319 (62%)
		Interaction with SF3B1. /evidence=ECO:0000269\|PubMed:27720643	1028..1049		14/20 (70%)
		Interaction with SF3B5. /evidence=ECO:0000269\|PubMed:27720643	1100..1123		15/22 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160159
Domainoid	1	1.000	921	1.000	Domainoid score	I45
eggNOG	1	0.900	-	-		E1_KOG1898
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6579
Inparanoid	1	1.050	1895	1.000	Inparanoid score	I59
Isobase	1	0.950	-	0	Normalized mean entropy	S1325
OMA	1	1.010	-	-		QHG54483
OrthoDB	1	1.010	-	-		D57158at33208
OrthoFinder	1	1.000	-	-		FOG0004388
OrthoInspector	1	1.000	-	-		oto88985
orthoMCL	1	0.900	-	-		OOG6_102496
Panther	1	1.100	-	-	LDO	PTHR10644
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1253
SonicParanoid	1	1.000	-	-		X3106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750