DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3b3 and AgaP_AGAP011340

DIOPT Version :9

Sequence 1:	NP_728546.1	Gene:	Sf3b3 / 38093	FlyBaseID:	FBgn0035162	Length:	1227	Species:	Drosophila melanogaster
Sequence 2:	XP_309311.4	Gene:	AgaP_AGAP011340 / 1270599	VectorBaseID:	AGAP011340	Length:	1434	Species:	Anopheles gambiae

Alignment Length:	1564	Identity:	287/1564 - (18%)
Similarity:	528/1564 - (33%)	Gaps:	482/1564 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LYNLTLQ--KATGVTHAVHGNFSGGKQQEVLLSRGKSLELLR--PDSNTG-------------KV 50
            :::|..|  :||.|..::..:|....::.::......|::.|  ||::..             |:
Mosquito     1 MFSLCKQPHEATAVEFSLTCHFFNHNEKSLVTGGANVLKVYRVIPDADPATRDKYTAARPPNMKL 65

  Fly    51 HTLLSTEIFGCVRALMAFRLTGGTKDYIVVGSDSGRIVILEYNPSKNALEKVHQETFGKSGCRRI 115
            ..:.|..:.|.::::.:..|.|..:|.:::.....::.:::::|....|:.:....|.....|..
Mosquito    66 ECVASYRLNGNIKSMQSVSLAGSLRDALLISFPDAKLSVVQFDPDNFDLKTLSLHYFEDEDIRGG 130

  Fly   116 VPGQY----FAIDPKGR-AVMIGAVEKQKLAYIMNRDTQA-----------------RLTISSPL 158
            ..|.|    ..:||..| |||:  |..:||..:..|...:                 :|...:|:
Mosquito   131 WTGHYHIPMVRVDPDNRCAVML--VYGRKLVVLPFRKDSSLDEIELQDVKPIKKAPMQLVAKTPI 193

  Fly   159 EAHKSNTLTYHMVGVDVGFDNPMFACLEIDYEEADMDPS------------GDAAQRTQQTLTFY 211
            .|    :....:..:|...||    .::|.:.....:|:            |..|.|: .|.|..
Mosquito   194 LA----SYIIELKDLDEKIDN----VIDIQFLHGYYEPTLLILYEPVRTFPGRIAVRS-DTCTMV 249

  Fly   212 ELDLGLNHVVRKY-----SEPLEEHANFLVSVPGGNDGPSGVLICSENYLTYKN---------LG 262
            .|.|.:...|...     |.|.:......::.|.|     |.|:...|.|.|.|         |.
Mosquito   250 ALSLNIQQRVHPVIWTVNSLPFDCIQAIPINKPIG-----GCLVMCVNSLIYLNQSVPPYGVSLN 309

  Fly   263 DQHDIRCPIPRRRND-----LD-------DPERGMIFICSATHRTKSMYFFLLQTEQGDIFKITL 315
            ...|.....|.:..|     ||       :||:                 .:|..:.|:::.:||
Mosquito   310 SSADHSTSFPLKPQDGVRISLDAAQVCFIEPEK-----------------LVLSLKGGELYVLTL 357

  Fly   316 ETDDDVVSEIKLKYFDTVPPA---TAMCVLKTGFLFVASEFGNHYLYQIAHLG-------DDDDE 370
            ..|.  :..::..:|:....:   :.:||.:..:||:.|..||..|.:.....       ||...
Mosquito   358 CADS--MRSVRNFHFNKAAASVLTSCICVCEDEYLFLGSRLGNSLLLRFKEKDESLVITIDDSGA 420

  Fly   371 PEFSSAMP-LEEGETFFFAPRALKNLVLV-------DELPSFAPI----ITSQVADLANEDTPQL 423
            .|.....| |||.|...:......::.|.       |.:.:..||    :..:||:...|:.|.:
Mosquito   421 VEKEPKRPRLEEEELEVYGSGYKTSVQLTSYIFEVCDNVLNIGPIAHMAVGERVAEEDAENQPDV 485

  Fly   424 YVL-----------CGRGPRSTLRVLRHGLEVSEMAVSELPGNPNAVWT-----VKKRADD--EF 470
            .::           .|.|....|.||:..::...:....|.|..: |||     |.:||:|  ..
Mosquito   486 QIVQNKLDIEVVTSSGHGKNGALCVLQSSIKPQVITSFGLSGCVD-VWTVFDEAVARRAEDGPST 549

  Fly   471 DAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLCCAALGDDA-LVQVYPDGIRHIR------ 528
            .|::|:|....|:||..||.:.|:.::||..|.||:....:|.:. :|||....||.::
Mosquito   550 HAFMILSQEGGTMVLQTGEEINEIENTGFATTVPTIHVGNIGTNRFIVQVTTKSIRLLQGTRLLQ 614

  Fly   529 ------------------------SDKRV-----NEWKAPGKKSITKCAVNQRQVVITLSGRELV 564
                                    |:.||     .|.|...:.::.|..::....|:.:|....|
Mosquito   615 NIPIDLGCPLASVAIVDPYVCVRSSEGRVITLALREGKGTPRLAVNKNTISPTPAVVAISAYRDV 679

  Fly   565 ----------YFEMDPTGELNEYTE-------------------------RSEMPAEIMCMALGT 594
                      .:::...|..:.|:.                         ||.....:..||:..
Mosquito   680 SGLFTKKIEDVYDLSRGGAASAYSSGFGSMKPEPHMKIEDEEDLLYGESGRSFKMTSMADMAIAG 744

  Fly   595 VPEGEQRSW-----------FLAVGLADNTVRILSL-------------DPNNCLTPCSMQALPS 635
            ...|....|           :|.....:.|:.|.|:             :.|..|:. ||:.:|.
Mosquito   745 KSGGSADFWMKYMQQVKPTYWLFAARDNGTLEIYSMPDLKLVYLITNVGNGNKVLSD-SMEFVPL 808

  Fly   636 PAESLCLVEMGHTESTTQGGLDDDAPAQRSGNNKGTIYLNIGLSNGVLLRTVLDPVSGDLADTRT 700
            |        ||.:.|      .:||        ......:.|:|..:|.:.:|....|.
Mosquito   809 P--------MGKSAS------QEDA--------SSAFGASFGVSASLLPKEILMVALGS------ 845

  Fly   701 RYLGSRPV------------KLFR-----IKMQ-------------------GSEAVLAMSSRTW 729
              .||||:            ::||     :|::                   |:.|..|.:
Mosquito   846 --YGSRPLLFIRLEHDLLIYRVFRYSKGHLKLRFKRLSTSVTCPVFRTPEPSGAGATEAAN---- 904

  Fly   730 LSYYHQNRFHLTPLSYETLEYASGFSSEQCSEGIVA---------------ISTNTLRILALEKL 779
                .|.:...|.:.||.:.....|::.....|:..               :.::.|....:.|.
Mosquito   905 ----EQQQARATKVLYENISMIRYFANVSGYAGVAVCGEKPYFLFLTAHGELRSHRLYARTVMKA 965

  Fly   780 GAVFNQV---------------------------------AFPLQYTPRTFVIHPDTGRMLI--- 808
            .|.||.|                                 ..||:.:|:..|.|.:.....:
Mosquito   966 FAPFNNVNCPNGFLYFDEQYELKISIFPTYLSYDSVWPVRKIPLRSSPKQIVYHRENKVYCVVMD 1030

  Fly   809 AETDHNAY---TEDTKSARKEQMAEEMRSAAGDEERELAREMANAFINEVLPEDVFSSPKAGLGL 870
            ||...|.|   ..:.|...:|...|......|   ...:..:......||:||.
Mosquito  1031 AEEICNKYYRFNGEDKELTEENKGERFLYPMG---HRFSVVLVTPAAWEVVPET----------- 1081

  Fly   871 WASQIRCLDAMHGQTMFSVPLTQNEAIMSM--AMLKFSIAADG-RYYLAVG----IAKDLQLNPR 928
                             |:.|.:.|.::::  ..|.:..|..| :.|:|||    .::|:....|
Mosquito  1082 -----------------SINLEEWEHVIALKNVSLTYEGARSGLKEYIAVGTNFNYSEDITSRGR 1129

  Fly   929 ISQGGCIDIYKIDPTCSSLEFMHR---TDIDEIPGA------LCGFQGRLLAGCGRMLRIYDFGK 984
            :.   ..||.::.|........|:   ..:.:..|.      :|||   |:...|:.:.::....
Mosquito  1130 LL---LYDIIEVVPEPGKPLTKHKFKEVIVKDQKGPVSAISHVCGF---LVGAVGQKVYLWQMKD 1188

  Fly   985 KKMLRKC--ENKHIPYQIVNIQAMGHRVYVSDVQESVFFIRYRRAENQLIIFADDTHPRWVTATT 1047
            ..::...  :.....:|:|:|:::   :.|:||.:||..:|::.....|.:.:.|.||
Mosquito  1189 DDLVGVAFIDTNIFVHQMVSIKSL---ILVADVYKSVSLLRFQEEYRTLSVVSRDYHP------- 1243

  Fly  1048 LLDYDTIAIADKFGNLSIQRLPHSVTDDVDE------DPTGTKSLWDRGLLSGASQKSE------ 1100
            |..:....:.|. .||..     .|:||...      .|...:|...:.||    :||:
Mosquito  1244 LNVFQVEYVVDN-ANLGF-----LVSDDQCNLITYMYQPESRESFGGQRLL----RKSDYHLGQQ 1298

  Fly  1101 -NI-----CSFHVGEIIMSLQKATLIPGGSEALIYATLSGTVGAFVPFTSREDYDFFQHLEMHMR 1159
             |.     |.||..:::    |.||.........:|||.|.:|..:|...:.....|. |:..:.
Mosquito  1299 VNCMFRVQCDFHETDVM----KRTLNYDNKHTTFFATLDGGIGFVLPLPEKTYRRLFM-LQNVLL 1358

  Fly  1160 NENPPLCGRDHLSYRS-------SYYPVKNVLDGDLCEQYLSIEAAKQKSIAGDMFRTPNQICKK 1217
            ..:|..||.:..:||:       ...|.:.|:||||...:|.:.|.::..:|..:.....:||..
Mosquito  1359 THSPHTCGLNPKAYRTIKQTRKLPINPSRCVVDGDLVWSFLELPANEKHEVAKKIGTRIEEICAD 1423

  Fly  1218 LEDI 1221
            |.:|
Mosquito  1424 LMEI 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3b3	NP_728546.1	MMS1_N	76..592	CDD:402179	129/686 (19%)
Sf3b3	NP_728546.1	CPSF_A	872..1194	CDD:397339	74/364 (20%)
AgaP_AGAP011340	XP_309311.4	SFT1	1..1428	CDD:227490	287/1564 (18%)
		MMS1_N	101..646	CDD:287414	117/580 (20%)
		CPSF_A	1064..1400	CDD:281209	78/394 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910