Protein Alignment CG13895 and TIGD3

DIOPT Version :10

• Sequence 1: NP_001261220.1
• Gene: CG13895 / 38087
• FlyBaseID: FBgn0035158
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_663771.1
• Gene: TIGD3 / 220359
• HGNCID: 18334
• Length: 471
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 115/552 - (20%)
• Similarity: 188/552 - (34%)
• Gaps: 169/552 - (30%)

  Fly    27 NVLTLEERVAAIRQYDIVPM-YSKIARNFNCSWEQIKSIVSNREAILEFHKATNRLSQPANKDAE 90
            :.|:|.|::..:...|...| .|::||.|..|..||..|..|:|.:|     .:..|..||::.:
Human    10 HALSLAEKIQVLELLDESKMSQSEVARRFQVSQPQISRICKNKEKLL-----ADWCSGTANRERK 69

  Fly    91 LRRRKLNFLG-----HCLYEYIQRAQFYLHSDVNEEMIRNRAIEFRDLMQLDGFVPNKPWINHFK 150
             |:|:..:.|     .|.| :|.||:.:   ||...|:.::|.|..|:|..| |||:..|:..:|
Human    70 -RKRESKYSGIDEALLCWY-HIARAKAW---DVTGPMLLHKAKELADIMGQD-FVPSIGWLVRWK 128

  Fly   151 AAYNITLSNRQITIVRRPPRSMDLRDIMSYCGRHTSMSCSLAPRSPEPALTSSDRP-LYRT---- 210
            ...|:....|.:.....||.... ..:.|    ...:..||...|||.....::.| |||.
Human   129 RRNNVGFGARHVLAPSFPPEPPP-PGLTS----QAQLPLSLKDFSPEDVFGCAELPLLYRAVPGS 188

  Fly   211 -----KTLVTTSSQNQATSDEVHLRRKRKLAFLE---KCVYEYIQRSQLVRQGRLDLDNLRFVAI 267
                 :..|...:.::.|.     :|:..|..|:   :|.:                 .:|..|:
Human   189 FGACDQVQVLLCANSRGTE-----KRRVLLGGLQAAPRCFF-----------------GIRSEAL 231

  Fly   268 SLRDILKIDSFFPDK--VWLKHFKSRYNFNFTVGVQVTNRRLPLSLDLRDIVSYCGRNEHKITLD 330
            ..       |:.||.  .||:...   .|:..:|.|  .|::.|.|..|.:....|..    .|.
Human   232 PA-------SYHPDLGIPWLEWLA---QFDRDMGQQ--GRQVALLLAARVVEELAGLP----GLY 280

  Fly   331 HKKSQEELSQSDKPEVDQCPQVEPKPE--------EFEH-----------EEDDDCVA------- 369
            |.|.....:.|..|         |.|.        .:.|           |.|...:|
Human   281 HVKLLPLAASSTTP---------PLPSSVVRAFKAHYRHRLLGKLAAIQSERDGTSLAEAGAGIT 336

  Fly   370 ------------IEVPPELI-------EIKDDEDNDDEHNDNEDLPERATKRKSDENGGPIPCGL 415
                        .:|||:||       .:...:.....|..:| :|             |:|.||
Human   337 VLDALHVASAAWAKVPPQLIFSSFIQEGLAPGKTPPSSHKTSE-MP-------------PVPGGL 387

  Fly   416 KIQKIQSLNESLPEDTELLPANSP---------GHYSETSDEAHLPRCVESYKDALRLLKPLEEF 471
            .:::.....:        |....|         |...|..|.......:.:..||||.|..|..:
Human   388 SLEEFSRFVD--------LEGEEPRSGVCKEEIGTEDEKGDREGAFEPLPTKADALRALGTLRRW 444

  Fly   472 VLMEENYRAIGLLTQLEKIFESAAKKSEEMDK 503
              .|.|       :...::||......||:::
Human   445 --FECN-------STSPELFEKFYDCEEEVER 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13895	NP_001261220.1	CENP-B_N	24..74	CDD:461229	16/47 (34%)
		CENPB	93..159	CDD:197828	21/70 (30%)
		CENPB	232..298	CDD:197828	11/70 (16%)
TIGD3	NP_663771.1	CENP-B_N	6..57	CDD:461229	16/51 (31%)
		HTH_Tnp_Tc5	76..133	CDD:460850	19/61 (31%)
		DDE_3	193..360	CDD:481203	37/213 (17%)