DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13894 and THAP3

DIOPT Version :9

Sequence 1:	NP_612054.1	Gene:	CG13894 / 38086	FlyBaseID:	FBgn0035157	Length:	528	Species:	Drosophila melanogaster
Sequence 2:	NP_001381425.1	Gene:	THAP3 / 90326	HGNCID:	20855	Length:	246	Species:	Homo sapiens

Alignment Length:	287	Identity:	56/287 - (19%)
Similarity:	101/287 - (35%)	Gaps:	73/287 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RRCCIIGCLSNSRQHPSMQFFAFPRPENPFHKLWKE-ACHASLRRIVPFKKPVVCALHFDP---S 65
            |:||  ...|:.|:..:...|.|.|||     |.|| ..:.......|.:..|:|:.||.|   |
Human     8 RQCC--NRYSSRRKQLTFHRFPFSRPE-----LLKEWVLNIGRGNFKPKQHTVICSEHFRPECFS 65

  Fly    66 VLGGRR-LQSNALPTL------RLEVPSNLEAVEQQ--AMVEEIERSRKCAYINAVVYEWLVRAN 121
            ..|.|: |:.||:||:      ..:|..|.:...::  |...:.|::..|            |:.
Human    66 AFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERGNASSSQKEKTSPC------------RSQ 118

  Fly   122 INPQL-RGSITHGMIKDKAENARQVIGSTSFIADNRWLNRFRETHLQGFAQKLASNQLKPLGSSL 185
            :.|:. .|..:.|...|.|....|:                 ..:.:|..::::..:
Human   119 VLPEAGAGEDSPGRNMDTALEELQL-----------------PPNAEGHVKQVSPRR-------- 158

  Fly   186 WIPDIVQDLAHLFPPASAERVAKLEEMPEQYMTYMQQYGEYEEDDDSMDVKEQSYQEQQQQQQQH 250
              |...:.:.....||...|....:.....|...         |.||:  |::.:...::.::..
Human   159 --PQATEAVGRPTGPAGLRRTPNKQPSDHSYALL---------DLDSL--KKKLFLTLKENEKLR 210

  Fly   251 FALQQQHMQQQQHQMGHPWPPFPGHPG 277
            ..||.|.:..:  :|........||.|
Human   211 KRLQAQRLVMR--RMSSRLRACKGHQG 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13894	NP_612054.1	THAP	6..82	CDD:214951	26/86 (30%)
		CENPB	104..165	CDD:197828	8/61 (13%)
		NST1	382..>468	CDD:290656
THAP3	NP_001381425.1	THAP	4..82	CDD:214951	27/80 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144926
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930