DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vti1a and VTI1A

DIOPT Version :9

Sequence 1:	NP_612053.1	Gene:	Vti1a / 38085	FlyBaseID:	FBgn0260862	Length:	230	Species:	Drosophila melanogaster
Sequence 2:	NP_001305132.1	Gene:	VTI1A / 143187	HGNCID:	17792	Length:	224	Species:	Homo sapiens

Alignment Length:	218	Identity:	81/218 - (37%)
Similarity:	140/218 - (64%)	Gaps:	4/218 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EQYEQQYATLIAEITAHIGRLQQQNNNSERHDLCSKIDSSLPEAQELLEQMGLEVRELNPGLRSS 69
            |.|||.:|.|.||||:.|.|:.:...: |:..:.:.::..|.||:||||||.|||||:.|..|..
Human     6 EGYEQDFAVLTAEITSKIARVPRLPPD-EKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGM 69

  Fly    70 FNGKLQVAQAELKRLQAEYRLTKDKQRSQANTFTTLDLGDSYEDVSIS-TDQRQRLLDNSERIER 133
            ::.:::..:.|:.:|:.:::.::.....:.......|.|:|.|:..|. .::|..||||:||:||
Human    70 YSNRMRSYKQEMGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQLIKLREERAHLLDNTERLER 134

  Fly   134 TGNRLTEGYRVALETEQLGAQVLNDLHHQRETLQGARARLRETNAELGRASRTLNTMMLRALREK 198
            :..||..||::|:||||:|.::|.:|.|.||.:|.||.|||||:|.||::||.|..|:.|.::.:
Human   135 SSRRLEAGYQIAVETEQIGQEMLENLSHDREKIQRARERLRETDANLGKSSRILTGMLRRIIQNR 199

  Fly   199 VVLYGVGVCFVVAVGVSLYLTFA 221
            ::|..:|:  :|.:.:.:.:||:
Human   200 ILLVILGI--IVVITILMAITFS 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vti1a	NP_612053.1	V-SNARE	11..89	CDD:282816	27/77 (35%)
Vti1a	NP_612053.1	SNARE_Vti1a	128..189	CDD:277244	33/60 (55%)
VTI1A	NP_001305132.1	V-SNARE	12..90	CDD:368237	27/78 (35%)
VTI1A	NP_001305132.1	SNARE_Vti1a	129..190	CDD:277244	33/60 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143555
Domainoid	1	1.000	75	1.000	Domainoid score	I9091
eggNOG	1	0.900	-	-		E1_KOG1666
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39963
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4391
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54893
OrthoDB	1	1.010	-	-		D1195966at2759
OrthoFinder	1	1.000	-	-		FOG0003233
OrthoInspector	1	1.000	-	-		oto88550
orthoMCL	1	0.900	-	-		OOG6_101479
Panther	1	1.100	-	-	LDO	PTHR21230
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1665
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800