DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vti1a and VTI1B

DIOPT Version :9

Sequence 1:	NP_612053.1	Gene:	Vti1a / 38085	FlyBaseID:	FBgn0260862	Length:	230	Species:	Drosophila melanogaster
Sequence 2:	NP_006361.1	Gene:	VTI1B / 10490	HGNCID:	17793	Length:	232	Species:	Homo sapiens

Alignment Length:	205	Identity:	52/205 - (25%)
Similarity:	91/205 - (44%)	Gaps:	15/205 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RLQQQNNNSERHDLCSKIDSSLPEAQELLEQMGLEVRELNPGLRSSFNGKLQVAQAELKRLQAEY 88
            ||.......|:..|....|....||.|.|.:|..|:|......|:....||:..:.:|.:|..|.
Human    31 RLLGTAGTEEKKKLIRDFDEKQQEANETLAEMEEELRYAPLSFRNPMMSKLRNYRKDLAKLHREV 95

  Fly    89 RLTKDKQRSQANTFTTLDLGD--------SYEDVSISTDQRQRLLDNSERIERTGNRLTEGYRVA 145
                   ||...|.|....||        ..|.::....||..||..:|.:.|....:...:|:|
Human    96 -------RSTPLTATPGGRGDMKYGIYAVENEHMNRLQSQRAMLLQGTESLNRATQSIERSHRIA 153

  Fly   146 LETEQLGAQVLNDLHHQRETLQGARARLRETNAELGRASRTLNTMMLRALREKVVLYGVGVCFVV 210
            .||:|:|::::.:|..||:.|:..::||..|:..|.::.:.|.:|..:....|::|..:.:..:.
Human   154 TETDQIGSEIIEELGEQRDQLERTKSRLVNTSENLSKSRKILRSMSRKVTTNKLLLSIIILLELA 218

  Fly   211 AVGVSLYLTF 220
            .:|..:|..|
Human   219 ILGGLVYYKF 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vti1a	NP_612053.1	V-SNARE	11..89	CDD:282816	18/64 (28%)
Vti1a	NP_612053.1	SNARE_Vti1a	128..189	CDD:277244	17/60 (28%)
VTI1B	NP_006361.1	Interaction with CLINT1. /evidence=ECO:0000269\|PubMed:18033301, ECO:0007744\|PDB:2V8S	2..23
		V-SNARE	18..96	CDD:309928	18/71 (25%)
		Interaction with CLINT1. /evidence=ECO:0000269\|PubMed:18033301, ECO:0007744\|PDB:2V8S	69..73		0/3 (0%)
		SNARE_Vti1b	136..197	CDD:277243	17/60 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1666
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54893
OrthoDB	1	1.010	-	-		D1195966at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830