Protein Alignment RabX6 and RAB1B

DIOPT Version :10

• Sequence 1: NP_001261219.1
• Gene: RabX6 / 38084
• FlyBaseID: FBgn0035155
• Length: 222
• Species: Drosophila melanogaster
• Sequence 2: NP_112243.1
• Gene: RAB1B / 81876
• HGNCID: 18370
• Length: 201
• Species: Homo sapiens
• Alignment Length: 196
• Identity: 71/196 - (36%)
• Similarity: 108/196 - (55%)
• Gaps: 11/196 - (5%)

  Fly    10 KVILCGDYGVGKSSLFRRFATNTFITDTDRKSTLGLDHIDREYSVNEKQIKLQLWDTGGMERVAS 74
            |::|.||.|||||.|..|||.:|: |:: ..||:|:|...|...::.|.||||:|||.|.||..:
Human    10 KLLLIGDSGVGKSCLLLRFADDTY-TES-YISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRT 72

  Fly    75 VTSSYYKFAEGAILVFALDNAASFHSLSQHLLDIVTYA-ENAKIFICGNKSDLDGREPEVSDEEV 138
            :|||||:.|.|.|:|:.:.:..|:.::.|.|.:|..|| ||....:.||||||..:: .|.:...
Human    73 ITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKK-VVDNTTA 136

  Fly   139 EAFCEQCHSLISATYKTSCRSGAGVEEMF----RDISRQLVHANRSKMELQALEHKSFQVDTASS 199
            :.|.:   ||.....:||.::...||:.|    .:|.:::.....|..|...|:..|..|..|..
Human   137 KEFAD---SLGIPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLKIDSTPVKPAGG 198

  Fly   200 G 200
            |
Human   199 G 199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RabX6	NP_001261219.1	Rab	10..172	CDD:206640	64/166 (39%)
RAB1B	NP_112243.1	Rab1_Ypt1	7..172	CDD:206661	64/167 (38%)
		Switch 1. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	30..45		5/16 (31%)
		Switch 2 region, required for interaction with REP1/CHM	64..83		10/18 (56%)
		Switch 2. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	65..80		8/14 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..201		7/26 (27%)