DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hiro and Cpvl

DIOPT Version :9

Sequence 1:	NP_612051.1	Gene:	hiro / 38083	FlyBaseID:	FBgn0035154	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_006506676.1	Gene:	Cpvl / 71287	MGIID:	1918537	Length:	484	Species:	Mus musculus

Alignment Length:	438	Identity:	112/438 - (25%)
Similarity:	190/438 - (43%)	Gaps:	63/438 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GPGDQDW-GFVDVRT--GAHMFYWLYYTTANVSSYTERPLAIWLQGGPGASSTGYGNFEELGPLK 89
            |..|:.: |::.|..  .:::|:|.:.......   :.|:.:|||||||.||. :|.|.|.||..
Mouse    76 GMNDKSYAGYITVNQTYNSNLFFWFFPARMQPE---DAPVVLWLQGGPGGSSM-FGLFVEHGPYI 136

  Fly    90 LDGSY----RDWTWVKDMNVMFIDNPVGSGFSYVDGSSYYTTNNKQIALDLVELMKGFYTNHPEF 150
            :..:.    ||:.|...:::::||||||:|||:.|....|.|:...:|.||...:..|:|..||:
Mouse   137 ITSNMTVVARDFPWTFTLSMLYIDNPVGTGFSFTDHFQGYATSEDDVAQDLYSALIQFFTLFPEY 201

  Fly   151 KTVPLHIFCESYGGKMAPEFALELDYAIKRGEIESNFVSVALGDPWTSPIDSVLSWAPFLLQLGI 215
            .....::..|||.||..|..|..:.......:.:.....:|:||.:|.|...:..:|.||.::|:
Mouse   202 AKNDFYVTGESYAGKYVPALAHYIHSLNPVRKFKIRLKGIAIGDAYTDPESIIGGYAAFLYEIGL 266

  Fly   216 VDQDGHDKIEASALKTKDYVDREKWTQA------------TLQWSSTQSVVLRESKGVDFYNVET 268
            :|:......:....|...|:..::|.:|            |...|..|:|    :...::||:..
Mouse   267 LDEQQQKYFQKQCSKCVKYIKEQEWMKAFEILDKLLDGDVTTGSSFFQNV----TGCTNYYNILQ 327

  Fly   269 PTLGDQYRLMSRAAMTPEEVMYRTLVKFDVDEDRDKLLEDLMLGPVTEALGI-NTGVKWGAQSGT 332
            .|             .|:|..|  ..||            |.|..|.:|:.: |.....||:
Mouse   328 CT-------------EPKEQSY--FAKF------------LTLPQVRQAIHVGNQNFSDGAE--- 362

  Fly   333 TFTKLMGDFMKPAVDVVGELLNNTTVKVGVFSGGLDLICATPGAVNWIEAMEWSAKPSYQVSPRV 397
            ....|..|.:|.....:.|::|  ..||.:::|.||:|.|.......:.||:|....:|:.:.|.
Mouse   363 VEKHLREDTVKSVKPWLSEIMN--YYKVLIYNGQLDIIVAAALTERSLMAMDWKGSRAYRRARRK 425

  Fly   398 GITV---DRVLEGYEKTYGNFSMFWVNRAGHMVPADNPAAMSHILRHF 442
            ...:   |..:.||.:..|.|....|...||::|.|.|.....::..|
Mouse   426 VWKIFKSDNEVAGYVRRVGKFHQVIVRGGGHILPYDQPMRSFDMINRF 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hiro	NP_612051.1	Peptidase_S10	29..444	CDD:298660	111/437 (25%)
Cpvl	XP_006506676.1	Peptidase_S10	78..474	CDD:366108	111/436 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54069
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850