DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hiro and CTSA

DIOPT Version :9

Sequence 1:	NP_612051.1	Gene:	hiro / 38083	FlyBaseID:	FBgn0035154	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001161066.1	Gene:	CTSA / 5476	HGNCID:	9251	Length:	481	Species:	Homo sapiens

Alignment Length:	502	Identity:	103/502 - (20%)
Similarity:	194/502 - (38%)	Gaps:	122/502 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IIALLALLGFAGLASVDARKGYGPGDQD-----------------WGFVDVRTGAHMFYWLYYTT 53
            ::.||.|:.:|.       :|....|||                 .|::......|:.||...:.
Human    31 LLLLLLLVSWAS-------RGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQ 88

  Fly    54 ANVSSYTERPLAIWLQGGPGASSTGYGNFEELGPLKLDGSYRDWTWVKDMNVMFIDNPVGSGFSY 118
            .:..:   .|:.:||.||||.||.. |...|.||..:            .||:::::|.|.||||
Human    89 KDPEN---SPVVLWLNGGPGCSSLD-GLLTEHGPFLI------------ANVLYLESPAGVGFSY 137

  Fly   119 VDGSSYYTTNNKQIALDLVELMKGFYTNHPEFKTVPLHIFCESYGGKMAPEFALELDYAIKRGEI 183
            .| ..:|.||:.::|....|.::.|:...||:|...|.:..|||.|...|..|:     :...:.
Human   138 SD-DKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAV-----LVMQDP 196

  Fly   184 ESNFVSVALGDPWTSPIDSVLSWAPFLLQLGIVDQDGHDKIE---ASALKTKDYVDREKWTQATL 245
            ..|...:|:|:..:|...:..|...|....|::.......::   .|..|...|.:::......|
Human   197 SMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNL 261

  Fly   246 QWSSTQSVVLRESKGVDFYNVETPTLG----------------DQYRLMSRAAMTPEEVMYRTLV 294
            |    :...:..:.|::.||:..|..|                |...:.:|..:  :.:.::.|:
Human   262 Q----EVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPL--KRMWHQALL 320

  Fly   295 KFDVDEDRDKLLEDLMLGPVTEALGINTGV----------------KW-------GAQSGTTFTK 336
            :     ..||:..|   .|.|.....:|.:                :|       ..|....:..
Human   321 R-----SGDKVRMD---PPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRS 377

  Fly   337 LMGDFMKPAVDVVGELLNNTTVKVGVFSGGLDLICATPGAVNWIEAMEWSAKPSYQVSP---RVG 398
            :...::|        ||::...::.:::|.:|:.|...|...:::::  :.|...|..|   :.|
Human   378 MNSQYLK--------LLSSQKYQILLYNGDVDMACNFMGDEWFVDSL--NQKMEVQRRPWLVKYG 432

  Fly   399 ITVDRVLEGYEKTYGNFSMFWVNRAGHMVPADNPAAMSHILRHFTKF 445
            .:.::: .|:.|.:.:.:...:..||||||.|.|.|.      ||.|
Human   433 DSGEQI-AGFVKEFSHIAFLTIKGAGHMVPTDKPLAA------FTMF 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hiro	NP_612051.1	Peptidase_S10	29..444	CDD:298660	96/476 (20%)
CTSA	NP_001161066.1	Peptidase_S10	57..477	CDD:278857	95/469 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940