DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hiro and scpep1

DIOPT Version :9

Sequence 1:	NP_612051.1	Gene:	hiro / 38083	FlyBaseID:	FBgn0035154	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_956486.1	Gene:	scpep1 / 393161	ZFINID:	ZDB-GENE-040426-890	Length:	445	Species:	Danio rerio

Alignment Length:	478	Identity:	177/478 - (37%)
Similarity:	260/478 - (54%)	Gaps:	69/478 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGRAIIALLALLGFA------GLASVDARKGYGPGDQDWGFVDVRTGAHMFYWLYYTTANVSSY 59
            |..|:.|.:|.:|.||      ....|.|:       :.||:||||.|||||:||||..::.:||
Zfish     1 MMARSWIGMLVVLLFAVSFYEGSCVPVQAK-------ESWGYVDVRDGAHMFWWLYYANSSSASY 58

  Fly    60 TERPLAIWLQGGPGASSTGYGNFEELGPLKLDGSYRDWTWVKDMNVMFIDNPVGSGFSYVDGSSY 124
            .|.||.:|||||||.||.|:|||||:|||..|...|:.:||:..:|:|:|||||:|:||.|....
Zfish    59 KELPLVMWLQGGPGGSSCGFGNFEEIGPLDRDLKLRETSWVRAASVLFVDNPVGTGYSYTDTEDA 123

  Fly   125 YTTNNKQIALDLVELMKGFYTNHPEFKTVPLHIFCESYGGKMAPEFALELDYAIKRGEIESNFVS 189
            .|.:...:|.|::.|:|.|::...||:::|.:||.||||||||...:|||..||:.|.|:.||..
Zfish   124 LTKDVAMVASDMMVLLKKFFSLKTEFQSIPFYIFSESYGGKMAAAISLELTKAIQAGSIKCNFAG 188

  Fly   190 VALGDPWTSPIDSVLSWAPFLLQLGIVDQDGHDKIEASALKTKDYVDREKWTQATLQWSSTQSVV 254
            |||||.|.||||||::|..:|....::|..|.:::..:|....:.|.:..:.:||..||..::||
Zfish   189 VALGDSWISPIDSVMTWGAYLYSTSLLDDTGLNEVYTAAKAVMEAVQQGDYLKATDLWSMIENVV 253

  Fly   255 LRESKGVDFYNVETPTLGDQYRLMSRAAMTPEEVMYRTLVKFDVDEDRD---------------- 303
            .:.:.||:|||:.|....:                   :||...|:..|
Zfish   254 EQNTNGVNFYNILTQNSDE-------------------MVKSSADQAADGFLLALKRRHIRPLHR 299

  Fly   304 KLLEDLMLGPVTEALG-INTGVKWGAQSGTTFTKLMGDFMKPAVDVVGELLNNTTVKVGVFSGGL 367
            :.|.:||.||:.:.|| |...|.||.|:...|..:.||||||.||||.:|| ...|.|.|::|.|
Zfish   300 QSLSELMNGPIRQKLGVIPKNVTWGGQAEDVFVSMAGDFMKPVVDVVDQLL-AAGVNVTVYNGQL 363

  Fly   368 DLICATPGAVNWIEAMEWSAKPSY-----------QVSPRVGITVDRVLEGYEKTYGNFSMFWVN 421
            |||..|.|...|::.::|....::           |...:.|        .:.|||.||:.:|:.
Zfish   364 DLIVDTMGQEMWVKKLKWDGLQNFNKLKWTALEDPQEQSQTG--------AFYKTYKNFAFYWIL 420

  Fly   422 RAGHMVPADNPAAMSHILRHFTK 444
            :||||:|:|.......:|:..|:
Zfish   421 KAGHMIPSDQGPMALRMLKMVTQ 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hiro	NP_612051.1	Peptidase_S10	29..444	CDD:298660	167/442 (38%)
scpep1	NP_956486.1	Peptidase_S10	26..439	CDD:298660	168/447 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592602
Domainoid	1	1.000	316	1.000	Domainoid score	I1245
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41443
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2521
OMA	1	1.010	-	-		QHG54069
OrthoDB	1	1.010	-	-		D274674at33208
OrthoFinder	1	1.000	-	-		FOG0003531
OrthoInspector	1	1.000	-	-		otm26594
orthoMCL	1	0.900	-	-		OOG6_105329
Panther	1	1.100	-	-	O	PTHR11802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2409
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770