DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hiro and Y32F6A.5

DIOPT Version :9

Sequence 1:	NP_612051.1	Gene:	hiro / 38083	FlyBaseID:	FBgn0035154	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001256221.1	Gene:	Y32F6A.5 / 179459	WormBaseID:	WBGene00012530	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	444	Identity:	174/444 - (39%)
Similarity:	255/444 - (57%)	Gaps:	13/444 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IIALLALLGFAGLASVDARKGYGPGDQDWGFVDVRTGAHMFYWLYYTTANVSSYTERPLAIWLQG 70
            |::|::|.......||:...|....|:|||:||:||.||.|:|||   |...:.::|||.:||||
Worm     6 ILSLVSLAAAGASNSVNTWGGVIQYDEDWGYVDIRTNAHTFWWLY---AAKPANSQRPLFLWLQG 67

  Fly    71 GPGASSTGYGNFEELGPLKLDGSYRDWTWVKDMNVMFIDNPVGSGFSYVDGSSYYTTNNKQIALD 135
            |||:||:|:|||||.||..|:||....||::..:::::|||||:||||||..|.|||...||..|
Worm    68 GPGSSSSGFGNFEETGPKTLNGSDNPATWLQVADMVYVDNPVGAGFSYVDDKSAYTTEITQIGKD 132

  Fly   136 LVELMKGFYTNHPEFKTVPLHIFCESYGGKMAPEFALELDYAIKRGEIESNFVSVALGDPWTSPI 200
            |:..::.|...|||::|.|.:||||||||||:.:||..:..:||.|.::.||.:|||||.|.|.:
Worm   133 LLAWLRKFLALHPEYRTRPFYIFCESYGGKMSAQFAKVITDSIKAGSLQLNFRAVALGDSWISAM 197

  Fly   201 DSVLSWAPFLLQLGIVDQDGHDKIEASALKTKDYVDREKWTQATLQWSSTQSVVLRESKGVDFYN 265
            |.|.:|.|:|.....:|....:.:.|.|.:.:..||::||.:||..|.:.::::..|:..|.:||
Worm   198 DYVNTWGPYLYANSFLDDHQLNTVNAEAARCQALVDQQKWEKATNCWGNMENLISVETNDVSWYN 262

  Fly   266 VETPTLGDQYRLMSRAAMTPEEVM---YRTLVKFDVDEDRDKLLEDLMLGPVTEALG-INTGVKW 326
            :......|.:   |.:||....||   .|...:|...::.|. |.:.|...|.:.|| |...||:
Worm   263 ILKKGDTDDW---SSSAMRSNRVMTSTRRLYNRFVAPQNLDS-LSNYMDTVVRKKLGIIPDKVKF 323

  Fly   327 GAQSGTTFTKLMGDFMKPAVDVVGELLNNTTVKVGVFSGGLDLICATPGAVNWIEAMEWSAKPSY 391
            |.|:|..|:...||||.|....|.:||.: ...|.|::|..||||.|.|...|:..:.|....::
Worm   324 GGQAGDVFSYQQGDFMTPIWSTVDQLLKD-GYNVIVYNGNEDLICNTMGTAAWVNRLTWDGAATF 387

  Fly   392 QVSPRVGI-TVDRVLEGYEKTYGNFSMFWVNRAGHMVPADNPAAMSHILRHFTK 444
            ..:.|... |....|.||.|||.|...:|:.||||||..|.|.:...:|:...|
Worm   388 NSTTRHSFKTQSFPLAGYYKTYKNLQFWWILRAGHMVAYDTPESAIFMLKAVVK 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hiro	NP_612051.1	Peptidase_S10	29..444	CDD:298660	167/419 (40%)
Y32F6A.5	NP_001256221.1	Peptidase_S10	34..442	CDD:415488	166/416 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	306	1.000	Domainoid score	I738
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41443
Inparanoid	1	1.050	311	1.000	Inparanoid score	I1546
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54069
OrthoDB	1	1.010	-	-		D274674at33208
OrthoFinder	1	1.000	-	-		FOG0003531
OrthoInspector	1	1.000	-	-		otm14371
orthoMCL	1	0.900	-	-		OOG6_105329
Panther	1	1.100	-	-	O	PTHR11802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	1	1.000	-	-		X2409
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.010