DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hiro and Scpep1

DIOPT Version :9

Sequence 1:	NP_612051.1	Gene:	hiro / 38083	FlyBaseID:	FBgn0035154	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_017452440.1	Gene:	Scpep1 / 114861	RGDID:	620067	Length:	461	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	166/434 - (38%)
Similarity:	246/434 - (56%)	Gaps:	38/434 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GDQDWGFVDVRTGAHMFYWLYYTTANVSSYTERPLAIWLQGGPGASSTGYGNFEELGPLKLDGSY 94
            |.:.|.:|.||..|.||:||||.|....:::|.||.:|||||||.||||:|||||:|||......
  Rat    45 GKEVWDYVTVREDARMFWWLYYATNPCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDTRLKP 109

  Fly    95 RDWTWVKDMNVMFIDNPVGSGFSYVDGSSYYTTNNKQIALDLVELMKGFYTNHPEFKTVPLHIFC 159
            |:.||::..:::|:|||||:|||||:.:..|..:...:|.|::.|:|.|:..|.||:|||.:||.
  Rat   110 RNTTWLQWASLLFVDNPVGTGFSYVNTTDAYAKDLDTVASDMMVLLKSFFDCHKEFQTVPFYIFS 174

  Fly   160 ESYGGKMAPEFALELDYAIKRGEIESNFVSVALGDPWTSPIDSVLSWAPFLLQLGIVDQDGHDKI 224
            ||||||||...:|||..||::|.|:.||..|||||.|.||:||||||.|:|..:.::|..|..::
  Rat   175 ESYGGKMAAGISLELHKAIQQGTIKCNFSGVALGDSWISPVDSVLSWGPYLYSVSLLDNKGLAEV 239

  Fly   225 EASALKTKDYVDREKWTQATLQWSSTQSVVLRESKGVDFYNVETPTLGDQYRLMSRAAMTPEEVM 289
            ...|.:..:.|::..:.:||..|...:.::.:.:.||:|||:.|.:             ||:..|
  Rat   240 SDIAEQVLNAVNKGFYKEATQLWGKAEMIIEKNTDGVNFYNILTKS-------------TPDTSM 291

  Fly   290 YRTLVKF----------DVDEDRDKLLEDLMLGPVTEALG-INTGVKWGAQSGTTFTKLMGDFMK 343
            ..:|..|          .|...:...|..||.||:.:.|. |...|.|||||.:.|..:..||||
  Rat   292 ESSLEFFRSPLVRLCQRHVRHLQGDALSQLMNGPIKKKLKIIPDDVSWGAQSSSVFISMEEDFMK 356

  Fly   344 PAVDVVGELLNNTTVKVGVFSGGLDLICATPGAVNWIEAMEWSAKPSYQ--------VSPRVGIT 400
            |.:|:|..|| ...|.|.|::|.||||..|.|..:|::.::|.....:.        .:|:...|
  Rat   357 PVIDIVDTLL-ELGVNVTVYNGQLDLIVDTIGQESWVQKLKWPQLSRFNQLKWKALYTNPKSSET 420

  Fly   401 VDRVLEGYEKTYGNFSMFWVNRAGHMVPADNPAAMSHILRHFTK 444
                 ..:.|:|.|.:.:|:.:||||||||.......::|..|:
  Rat   421 -----SAFVKSYENLAFYWILKAGHMVPADQGDMALKMMRLVTQ 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hiro	NP_612051.1	Peptidase_S10	29..444	CDD:298660	165/432 (38%)
Scpep1	XP_017452440.1	Peptidase_S10	46..455	CDD:395361	163/427 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350916
Domainoid	1	1.000	312	1.000	Domainoid score	I1263
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41443
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2504
OMA	1	1.010	-	-		QHG54069
OrthoDB	1	1.010	-	-		D274674at33208
OrthoFinder	1	1.000	-	-		FOG0003531
OrthoInspector	1	1.000	-	-		otm44704
orthoMCL	1	0.900	-	-		OOG6_105329
Panther	1	1.100	-	-	O	PTHR11802
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2409
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770