DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rev1 and poli

DIOPT Version :9

Sequence 1:	NP_612047.1	Gene:	Rev1 / 38079	FlyBaseID:	FBgn0035150	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001017834.1	Gene:	poli / 550532	ZFINID:	ZDB-GENE-050417-376	Length:	710	Species:	Danio rerio

Alignment Length:	799	Identity:	171/799 - (21%)
Similarity:	291/799 - (36%)	Gaps:	251/799 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 ERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHSKGGNAATDVPVHPQADRKAELELFAQRFEHH 336
            :|.::|.|:|||:..|.:...|.||..|:.:                           .|::
Zfish    36 QRVILHFDLDCFYAQVEMIRNPALRTKPLGI---------------------------QQKY--- 70

  Fly   337 FHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQALKLCPELKTIP-YDFEGYKEV 400
                                 .|.:.:|.|||.|:...|.|..|::.||:|..:. .|...|:|:
Zfish    71 ---------------------IIVTSNYVARELGVNKLMSVTDAVEKCPQLVLVKGEDLTHYREM 114

  Fly   401 AFTLYDTVAQYTLNIEAVSCDEMFVELTDLAH----ELNVDVMAFVSH----------------- 444
            ::.:.:.:..|...:|.:..||.|:::|::..    |..:..::|..|
Zfish   115 SYKVTELLMSYCPLVERLGFDENFMDVTEMVEKRIKETRISDLSFNGHVYNHESVVVDEENIRLA 179

  Fly   445 --------LRQEVYSKTGCPCSAGVAGNKLLARMATKEAKPNGQ-FLLDSSN-DILAYMAPMSLD 499
                    :||.::|..|....||||.|||||::.:...|||.| .||..|| ::::.:.  .|.
Zfish   180 VGSVIAAEMRQAIFSTLGLTGCAGVASNKLLAKLVSGSFKPNQQTTLLPHSNAELMSSLT--GLI 242

  Fly   500 LLPGVGSSISHKLKQAGLNNCGDVQNTTLEKMEKVLGK---KLGQNLFQNCRGIDDRPLAYEQIR 561
            .:||:|.....|||..||.|..|:|...|..:.|..|:   |..|||  .| ||||.|:......
Zfish   243 KVPGIGYKTREKLKALGLVNVRDLQLYPLSDLVKEFGEMNAKRVQNL--AC-GIDDSPVTPAGPP 304

  Fly   562 KTVSAEMNFGIRFTNSVE-----CEQFLCQLSEEV--------TKRLVEIR----------RKAR 603
            :::|.|.:|  :..:::|     .|:.|..|:|.:        |.||. ||          |::|
Zfish   305 QSLSDEDSF--KKMSTLEEVLKKIEELLINLTERMHKDGRQPHTLRLT-IRKYTVTNRWFNRESR 366

  Fly   604 S------INLKIMVRAAEAP---VETSKYMGHGVCD--------IIN------------KSSLIK 639
            .      ..|||...::||.   :..|..:.|.:.|        ::|            |||:..
Zfish   367 QCPIPNHTGLKITGGSSEAVPQLLSLSMKLFHKMVDPHQPFHLTLLNVCFSNLQAKSSSKSSIAS 431

  Fly   640 YATDDVNVITTVVLDLMKDADIPPDELRGLGIHLTRLEDANEVRKENNIKEMFGKMSEMRKDKPI 704
            :.|.. :..||.:.....|:|:.......   |.|:.    :|..:|:           :..||:
Zfish   432 FFTHK-SPSTTQIPSQQVDSDLCESVASS---HFTQA----DVLHKND-----------KAWKPV 477

  Fly   705 PQGAVGDKSIGDDKVNKPLVFENKPK----PREPRNVLSMLTAAAVSRKSVTEDRSQR----GTS 761
            ...::.........||        ||    ||:|           ||..|...:.:.|    .::
Zfish   478 NNTSISPTQTQSTSVN--------PKSSLSPRQP-----------VSEHSQHANINIRPPCLSSA 523

  Fly   762 KPITRPLSLVPKLDEDVLAQLPEDIRLEVIANREEHLCIAEYDGYRSP---------QYPTLRSP 817
            ...|....|.|.:|.||...|||.|::|::::      ..:.|.:..|         ..||..|.
Zfish   524 PKTTLHFKLPPNVDADVFKLLPEHIQMELMSS------FKKGDSFYRPADTEDVDPEHQPTFASR 582

  Fly   818 PLLNPYVTTNVSPLKATDLKPSTSRAAVARLQKRKERKEQEHY--------IRSDQIVADYIDDL 874
            ....|              ||..|...|.........:..:::        ..|:.::....||:
Zfish   583 QPKTP--------------KPCESAVNVCTNSASNPHELSQNFSSPQSIPEFSSELVMVTESDDI 633

  Fly   875 PDF-----------VNPHILKLISHPVEMPELLMGDNYKDLLNDWVSREEVPKPNDVDLILKQVS 928
            |..           |:|::..      ::|    .|..::||.:|..:..|.|...........|
Zfish   634 PHSTQAIQPEVPANVDPYVFS------QLP----ADVQRELLTEWRQQRPVLKIPSKHSHKSSNS 688

  Fly   929 RMIKNDQLDHVC-DVMKYW 946
            |..|.......| :::||:
Zfish   689 RDRKTSTKGSQCNNILKYF 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	116/490 (24%)
		Rev1_C	890..985	CDD:213388	13/58 (22%)
poli	NP_001017834.1	PolY_Pol_iota	40..418	CDD:176457	105/436 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810