DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rev1 and POLH

DIOPT Version :9

Sequence 1:NP_612047.1 Gene:Rev1 / 38079 FlyBaseID:FBgn0035150 Length:995 Species:Drosophila melanogaster
Sequence 2:NP_006493.1 Gene:POLH / 5429 HGNCID:9181 Length:713 Species:Homo sapiens


Alignment Length:746 Identity:160/746 - (21%)
Similarity:264/746 - (35%) Gaps:201/746 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   272 ERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHS---KGGNAATDVPVHPQADRKAELELFAQRF 333
            :|.|..:|||||||.|..|..|.||..|.||...   |||.                        
Human     6 DRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGG------------------------ 46

  Fly   334 EHHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQALKLCPELKTIPY------ 392
                                     |.:.|||||..|:...|:...|.||||:|.....      
Human    47 -------------------------IIAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGK 86

  Fly   393 -DFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTDLAHE----------------------- 433
             :...|:|.:..:.:.::::.: ||..|.||.:|:||....|                       
Human    87 ANLTKYREASVEVMEIMSRFAV-IERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL 150

  Fly   434 ---------------------------LNVDVM-----------AFVSHLRQEVYSKTGCPCSAG 460
                                       |.:|.:           ..|..:|..:..:||..||||
Human   151 PQGPTTAEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAG 215

  Fly   461 VAGNKLLARMATKEAKPNGQFLLD--SSNDILAYMAPMSLDLLPG-VGSSISHKLKQAGLNNCGD 522
            ::.||:||::|....|||.|.|:.  |...:.:.|....:..|.| :|:|:   ::..|:...|:
Human   216 ISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASV---IEILGIEYMGE 277

  Fly   523 VQNTTLEKMEKVLGKKLGQNLFQNCRGIDDRPLAYEQIRKTVSAEMNF--GIRFTNSVECEQFLC 585
            :...|..:::...|:|.|..|:..||||:..|:...|:.||:....||  ........:.:.:|.
Human   278 LTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLL 342

  Fly   586 QLSEEVTKRLVEIR----RKARSINLKIMVR-----------AAEAPVETSKYMGHGVCDII--- 632
            ||::|:.:||.:.|    |.|..:.:.|.|:           .|....:..| |.|....:|   
Human   343 QLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHK-MSHDAFTVIKNC 406

  Fly   633 NKSSL---------------IKYATDDVNVITTVVLDLMKDADIPPD--------ELRGLGIHLT 674
            |.|.:               .|::....:..|.:...|..|....|.        :.:|.|..:|
Human   407 NTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVPVTSSEAKTQGSGPAVT 471

  Fly   675 RLEDANEVRKENNIKEMFGKMSEMRKDKPIPQGAVGDKSIGDDKVNKPLVFENKP-KPREP-RNV 737
            ..:.|.     .:::..|.|.:|.:|        |.:.|:............|.| ||..| :..
Human   472 ATKKAT-----TSLESFFQKAAERQK--------VKEASLSSLTAPTQAPMSNSPSKPSLPFQTS 523

  Fly   738 LSMLTAAAVSRKSVTEDRSQ---RGTSKPITRPLSLVPKLDEDVLAQLPEDIRL-EVIANREE-- 796
            .|..|.....:||:...:.|   ...|.|...|.|....|...:..:.|..:.: |.::..||  
Human   524 QSTGTEPFFKQKSLLLKQKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPVCEGVSKLEESS 588

  Fly   797 HLCIAEYDGYRSPQ--YPTLRSPPLL--NPYVTTNVSPLKATDLKPSTSRAAVARLQKRKERKEQ 857
            ....||.|...:.|  :.:..|..:|  ....|.|.|.|.|.|..|.....::..:....|..: 
Human   589 KATPAEMDLAHNSQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEHMD- 652

  Fly   858 EHYIRSDQIVADYIDDLPDFVNPHILKLISH 888
              |..:.::...::.  |...||.::..:||
Human   653 --YHFALELQKSFLQ--PHSSNPQVVSAVSH 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rev1NP_612047.1 BRCT_Rev1 39..121 CDD:349351
PolY_Rev1 218..676 CDD:176455 114/520 (22%)
Rev1_C 890..985 CDD:213388
POLHNP_006493.1 DinP 7..>354 CDD:223466 94/399 (24%)
PolY_Pol_eta 10..428 CDD:176456 104/471 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..472 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 495..527 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 677..705 2/3 (67%)
PIP-box. /evidence=ECO:0000269|PubMed:15149598, ECO:0000269|PubMed:16357261 701..708
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0389
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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