DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rev1 and POLK

DIOPT Version :9

Sequence 1:	NP_612047.1	Gene:	Rev1 / 38079	FlyBaseID:	FBgn0035150	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001374040.1	Gene:	POLK / 51426	HGNCID:	9183	Length:	884	Species:	Homo sapiens

Alignment Length:	958	Identity:	184/958 - (19%)
Similarity:	334/958 - (34%)	Gaps:	310/958 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 DKAEVEVDSTKDETQMELGGILKNLQQAVATSPEKEASASESKITNLSTTSNNSTTARTAADPNF 218
            |..:.:.||.||:..:.:|   .|..:|.....:||      ||..:...:...
Human     2 DSTKEKCDSYKDDLLLRMG---LNDNKAGMEGLDKE------KINKIIMEATKG----------- 46

  Fly   219 LSEFY---------KNSRLHHIATLGAGFKQYVCRLRQKHGTQGFPKRETLKSLANSHHNCLERY 274
             |.||         .|.|:.::....|.......|..|....:...:.|..::|:|:
Human    47 -SRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNT-------- 102

  Fly   275 VMHIDMDCFFVSVGLRTRPELRGLPIAVTHSKGGNAATDVPVHPQADRKAELELFAQRFEHHFHD 339
            ::|||||.|:.:|.:|..|||:..||||.
Human   103 IVHIDMDAFYAAVEMRDNPELKDKPIAVG------------------------------------ 131

  Fly   340 GDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGM--FVGQALKLCPELKTIPYDFEGYKEVAF 402
                           |:|.:::.:|.||..|:|..|  |:  |.:|||:|..:|.:|:.|:.|:.
Human   132 ---------------SMSMLSTSNYHARRFGVRAAMPGFI--AKRLCPQLIIVPPNFDKYRAVSK 179

  Fly   403 TLYDTVAQYTLNIEAVSCDEMFVELT--------------------------DL----------- 430
            .:.:.:|.|..|..|:|.||.::.:|                          ||
Human   180 EVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDLQNLYIQRSITF 244

  Fly   431 ------------AHELNVDVMAF----------------------------------------VS 443
                        .||.::..:.|                                        |.
Human   245 TDNPGKEVNKLSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVK 309

  Fly   444 HLRQEVYSKTGCPCSAGVAGNKLLARMATKEAKPNGQF-LLDSSNDILAYMAPMSLDLLPGVGSS 507
            .:|..:..||....|||:|.|.:||::.:.:.|||||: :|.:...::.::..:.:..:.|:|..
Human   310 EIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKV 374

  Fly   508 ISHKLKQAGLNNCGDV--QNTTLEKMEKVLGKKLGQNLFQNCR-GIDDRPLAYEQIRKTVSAEMN 569
            ....||..|:..|.::  |...|    .:|..:...:.|.:.. |:....|..:..||::|.|..
Human   375 TEKMLKALGIITCTELYQQRALL----SLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERT 435

  Fly   570 FGIRFTNSVECEQFLCQ-LSEEVTKRLVEIRRKARSINLKIMVRAAEAPVETSKYMGHGVCDIIN 633
            |.  ..|..|.:..||| |..|:.:.|.:.|.|.|::.:|:  :.....|:|
Human   436 FS--EINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKL--KNVNFEVKT------------- 483

  Fly   634 KSSLIKYATDDVNVITTVVLDLMK---DADIP-PDELRGLGIHLTRLEDANEVRKENNIKEMFG- 693
            ::|.:.........|..:..:|:|   |||.| |..||.:|:.::..  .||..:::..:.:.|
Human   484 RASTVSSVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSF--PNEEDRKHQQRSIIGF 546

  Fly   694 --------KMSEMRKDKPIPQGAVGDKSIGDDKVNKPLVFENK----PKPREPRNVLSMLT--AA 744
                    ..:|...:|.       ||    ||..|||...:|    .|.|..|......|  ..
Human   547 LQAGNQALSATECTLEKT-------DK----DKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCE 600

  Fly   745 AVSRKSVTEDRSQRGTSKPITRPLSLVPKLDEDVLAQLPEDIR------LEVIANREEHLCIAEY 803
            ||:::|....:..:...|.:...|.:....|:..:...|...|      ||.: |:....|:
Human   601 AVNKQSFQTSQPFQVLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEAL-NKHVDECL--- 661

  Fly   804 DGYRSPQYPTLRSPPLLNPYVTTNVSPLKATDLKPSTSRAAVARLQKRK--------ERKEQEHY 860
            ||                |.::.|....       |.|..:..::.|::        |:::.|.:
Human   662 DG----------------PSISENFKMF-------SCSHVSATKVNKKENVPASSLCEKQDYEAH 703

  Fly   861 IRSDQI-------VADYIDDLPDFVNPHILKLISHPVEMPELLMGDNYKDLLNDWVSRE------ 912
            .:..:|       :.|.||:             |...|..:.|...:.|:..:...|:.
Human   704 PKIKEISSVDCIALVDTIDN-------------SSKAESIDALSNKHSKEECSSLPSKSFNIEHC 755

  Fly   913 EVPKPNDVDLILKQVSRMIKNDQLDHVCDV---MKYWCRIINMKRSSS 957
            .....:.|.|..:.|....:..:..::|:|   ....|.:.|:::.:|
Human   756 HQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCPVCNVEQKTS 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	117/566 (21%)
		Rev1_C	890..985	CDD:213388	12/77 (16%)
POLK	NP_001374040.1	PolY_Pol_IV_kappa	104..530	CDD:176459	106/499 (21%)
		ZnF_Rad18	635..661	CDD:128973	5/26 (19%)
		zf-WRNIP1_ubi	790..816	CDD:383112	3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..872
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810