DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rev1 and polk

DIOPT Version :9

Sequence 1:	NP_612047.1	Gene:	Rev1 / 38079	FlyBaseID:	FBgn0035150	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	XP_012822875.2	Gene:	polk / 448219	XenbaseID:	XB-GENE-985768	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	934	Identity:	183/934 - (19%)
Similarity:	324/934 - (34%)	Gaps:	305/934 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 LKNLQQAVATSPEKEASASESKITNLSTTSNNSTTARTAADPNFLSEFYKNSRLHHIATLGAGF- 238
            :.|.|:| |.:|.|||......:       |::.......|...:::...:      ||.|:.|
Frog     1 MDNKQEA-ALAPSKEAFQFRMGL-------NDNKAGMEGLDKEKINKIIMD------ATKGSRFY 51

  Fly   239 ----------KQYVCRLRQKHG--TQGFPKRETLK----SLANSHHNCLERYVMHIDMDCFFVSV 287
                      .|.:.:|.|:..  |....|:..::    :|....:..|.|.::|:|||.|:.:|
Frog    52 DNELKKDQQVNQRIEKLMQQKSQLTDQQIKKAQIQVDRLALELERNRDLSRIIVHVDMDAFYAAV 116

  Fly   288 GLRTRPELRGLPIAVTHSKGGNAATDVPVHPQADRKAELELFAQRFEHHFHDGDKAEKVRSGFDK 352
            .:|..|||:..|:||    |.|
Frog   117 EMRDSPELKDKPMAV----GSN------------------------------------------- 134

  Fly   353 KMSLSEIASCSYEAREKGIRNGM--FVGQALKLCPELKTIPYDFEGYKEVAFTLYDTVAQYTLNI 415
                |.:::.:|.||..|:|..|  |:  |.||||.||.:|.:|:.|:.|:..:.:.:|||..|.
Frog   135 ----SMLSTSNYLARRFGVRAAMPGFI--AKKLCPTLKIVPPNFDKYRAVSSEVREILAQYDPNF 193

  Fly   416 EAVSCDEMFVELTDLAHE-------------------------------------LNVDVMAFVS 443
            ..:|.||.::::||...|                                     |..|..:||:
Frog   194 LPMSLDEAYLDITDHLSERLAWPEDKRTFMIRTNNSGGNKPLPGKQEQVECTSPVLFEDSPSFVA 258

  Fly   444 -----------------------------------HLRQEVYSKTGCPCSAGVAGNKLLARMATK 473
                                               .:|..:..||....|||:|.|.:||::.:.
Frog   259 DQNFSQPGLGTTEENRKPSLENVVVFGTSVEEAVKEMRFRIEQKTTLTASAGIAPNMMLAKVCSD 323

  Fly   474 EAKPNGQF-LLDSSNDILAYMAPMSLDLLPGVGSSISHKLKQAGLNNCGDV-QNTTLEKMEKVLG 536
            :.|||||: :.:....|..::..:.:..:||:|......||..|:..|.|: |...|  :..:..
Frog   324 KNKPNGQYRIFNDKQAIKDFIKDLPIRKVPGIGKVTEKMLKALGIITCTDLYQQRAL--LSLLFS 386

  Fly   537 KKLGQNLFQNCRGIDDRPLAYEQIRKTVSAEMNFGIRFTNSVE----CEQFLCQLSEEVTK---- 593
            :...||......|:....:..:..||::|.|..|. ..::|.|    |::....|::::.|
Frog   387 ETSWQNFVHISLGLGSTHVERDGERKSMSTERTFS-EISSSEEQYGLCQELCRDLAQDLQKEGLK 450

  Fly   594 -RLVEIRRKARSINLKIMVRAAEAPVETSKYMGHGVCDIINKSSLIKYATDDVNVITTVVLDLMK 657
             :.|.|:.|    |:|..||.....|.::         :..:..:...|.:    |....:||
Frog   451 GKTVTIKLK----NVKFEVRTRALTVGST---------VSTEEEIFAVAKE----ILKAEIDL-- 496

  Fly   658 DADIPPDELRGLGIHLTRLEDANEVRKENNIKEMFGKMSEMRKDKPIPQGAVGDKSIGDDKVN-- 720
             |...|..||.:|:.::..  ..|..|:::.|.:.|   .:...||....::|.    .||.|
Frog   497 -ASPEPLRLRLMGVRVSGF--LTEEEKKHHQKSITG---FLHVSKPGSSSSLGQ----SDKANPS 551

  Fly   721 -------KPLVFENKPKPR-----EPRNVLSMLTAAAVSRKSVTEDRS-----QRGTSKP-ITRP 767
                   :...|..|...|     |...|.|....:..:..|.:|.::     :..:.|| .|.|
Frog   552 ALATGPQRQSFFNQKRAAREHMVQEKHAVCSGFVKSEDATISDSEGKTETLDLENVSQKPEFTCP 616

  Fly   768 LSLVPKLDEDVLAQLPEDIRLEVIANREEHL--CIAEYDGYRSPQYPTLRSPPLLNPYVTTN--- 827
            :..:.:.|.|             :|:..:|:  |::     |||....|.||......:..|
Frog   617 ICFLKESDWD-------------LASFNKHIDKCLS-----RSPISSELESPYKEGAVMMRNEVG 663

  Fly   828 ----------------------VSPLKATDLK--PSTSRAAVARLQKRKERKEQEHYIRSDQIVA 868
                                  ..||.|.|..  .:|....|..::......:..|.|.:..|..
Frog   664 DMEIQCEGIHNADVCAKKQIGHTRPLDAFDDSGINNTETTTVEDVEMNVNMDQSHHSIIATSIKN 728

  Fly   869 DYIDDLPDFVNPHILKLISHPVEMPELLMGDNYKDLLNDWVSREEVPKPNDVDLILKQVSRMIKN 933
            :|             |:.|.|:....|:   ..|..|:|    .||..|:..
Frog   729 EY-------------KMASEPIYAENLI---ECKVNLSD----TEVAHPSSA------------- 760

  Fly   934 DQLDHVCDVMKYWCRIINMKRSSS 957
                ..|:...:.|.:.|:::.::
Frog   761 ----APCEEQSFICPVCNIRQDTA 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	116/559 (21%)
		Rev1_C	890..985	CDD:213388	10/68 (15%)
polk	XP_012822875.2	PolY_Pol_IV_kappa	105..514	CDD:176459	104/484 (21%)
polk	XP_012822875.2	zf-WRNIP1_ubi	768..793	CDD:383112	2/13 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910