DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rev1 and DNApol-eta

DIOPT Version :9

Sequence 1:	NP_612047.1	Gene:	Rev1 / 38079	FlyBaseID:	FBgn0035150	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	181/930 - (19%)
Similarity:	308/930 - (33%)	Gaps:	314/930 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 SLANSH---HNCLERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHS---KGGNAATDVPVHPQA 320
            |.|.||   .|..:|.|:.:||||||..|..:..||.|..|:||...   :||.
  Fly     2 SSARSHVSMQNKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGG----------- 55

  Fly   321 DRKAELELFAQRFEHHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQALKLCP 385
                                                  |.:.:|.||.||:...|...:|..|||
  Fly    56 --------------------------------------IIAVNYAARAKGVTRHMRGDEAKDLCP 82

  Fly   386 E--LKTIP-----YDFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTDLAHE---------- 433
            |  |..:|     .|...|::....:.:.:.::|..:|..|.||.::::|:..:.
  Fly    83 EIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQMQSGAF 147

  Fly   434 -------LNVDVMAFVS------------------------------------------------ 443
                   :|...:.:.|
  Fly   148 ALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSDIRLLIGASVA 212

  Fly   444 -HLRQEVYSKTGCPCSAGVAGNKLLARMATKEAKPNGQFLLDSSNDILAYMAPMSLDLLP----- 502
             .:|..|..:||..||||:|.||:||::|....|||.|.:|..:.....:      |.||
  Fly   213 GEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLF------DSLPVGKIK 271

  Fly   503 GVGSSISHKL-KQAGLNNCGDVQNTTLEKMEKVLGKKLGQNLFQNCRGIDDRPLAYEQIRKTVSA 566
            |:|......: :..|:...|.|...:...:::...:|.|..||...||||...:......|::..
  Fly   272 GLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKSIGC 336

  Fly   567 EMNFGIR--FTNSVECEQFLCQLSEEVTKRL----VEIRRKARSINLKIMVRAAEAPVETSKYMG 625
            ...|..|  .|.....:.:|.:||.|:..||    :|..|:|:.:.::.:.......|.:|:
  Fly   337 CKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEEVASSR--- 398

  Fly   626 HGVCDIINKSSLIKYATDDVNVITTVVLDLMKDADI-----PPDE------LRGLGIHLTRLEDA 679
                    .::|..|   |...|..:.|||:| |:.     |..|      ::.|||.:.:.|..
  Fly   399 --------STALRDY---DQESIVRLSLDLIK-ANTKTFLRPGSESALNNAIKFLGISVGKFETV 451

  Fly   680 NEVRKENNIKEMFGKMSEMRK----DKP--IPQGAVGDKSIGDDKVNKPLVFEN-----KPKPRE 733
            :.  .:|.::|||...:..::    |:|  :|:..:..|....|:......|.|     |.:..:
  Fly   452 SS--GQNKLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAK 514

  Fly   734 PRNVLS--MLTAAAVSRKSVTED--------------------------------RSQRGTSKP- 763
            ...:.:  :..||....|:..|:                                :.|:.|.:.
  Fly   515 ADGISANPLAAAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKTGQQG 579

  Fly   764 --ITRPLSL-VPKLDEDVLA-------QLPEDIRLEVIANREEHLCIAEYDGYRSPQYPTLRSPP 818
              .:|..|| |.:|.|::.|       ...||...|.....:.|:...|.....:.|.   :.|.
  Fly   580 SVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQE---QDPN 641

  Fly   819 LLNP------YVTTNVSP--LKATDLKPSTSRAAVARLQKR----KE----------RKEQEHYI 861
            .||.      ||.|.:.|  |...:||||||:.....::..    ||          |.:....|
  Fly   642 TLNDSTGNDLYVETGIVPPTLTEDELKPSTSKRKFDEIESSVSNYKECYVEFAVPNLRTDILPTI 706

  Fly   862 RSDQI---VADYIDDLPDFVNPHILKLISHPVEMPELLMGDNYKDLLNDWVSREE---------- 913
            :.||.   :.|.:..|....:.|..:.:|..:...|                |||
  Fly   707 KCDQCGANIPDEVKSLQTHRDHHFAQELSRTLRSTE----------------REERTQSRQKISL 755

  Fly   914 ---------------------VPKPNDVDLIL--KQVSRMIKNDQLDHVCDVMKYWCRIINMKRS 955
                                 .|..|.:....  |.......:|...:.|...|.:.:.::|..
  Fly   756 KPTPPKKSKKTAGSGSSSYSTAPPSNSITKFFRAKPTQEQAPSDPQMNQCPECKAFIKCVDMPE- 819

  Fly   956 SSCCWHVAYKHIEESIQNQM 975
                 |:.| |:..::|.::
  Fly   820 -----HLDY-HVARNLQREL 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	110/515 (21%)
		Rev1_C	890..985	CDD:213388	15/119 (13%)
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	103/496 (21%)
		zf_UBZ	705..736	CDD:408236	6/30 (20%)
		zf_UBZ	805..832	CDD:408236	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740