DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rev1 and Poli

DIOPT Version :9

Sequence 1:	NP_612047.1	Gene:	Rev1 / 38079	FlyBaseID:	FBgn0035150	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_001099607.1	Gene:	Poli / 291526	RGDID:	1305212	Length:	732	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	174/791 - (21%)
Similarity:	294/791 - (37%)	Gaps:	223/791 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 AGFKQYVCRLRQKHGTQGFPKRETLKSLANSHHNCLERYVMHIDMDCFFVSVGLRTRPELRGLPI 300
            ||..:.||       .||.|.|     :|:|      |.::|:|:|||:..|.:.:.|||:..|:
  Rat    29 AGGSRAVC-------DQGAPSR-----IASS------RVIVHVDLDCFYAQVEMISNPELKDKPL 75

  Fly   301 AVTHSKGGNAATDVPVHPQADRKAELELFAQRFEHHFHDGDKAEKVRSGFDKKMSLSEIASCSYE 365
            .|                           .|::                        .:.:|:||
  Rat    76 GV---------------------------QQKY------------------------LVVTCNYE 89

  Fly   366 AREKGIRNGMFVGQALKLCPELKTI-PYDFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTD 429
            ||:.|::..|.|..|.:.||:|..: ..|...|:|:::.:.:.:.:::..:|.:..||.||:||:
  Rat    90 ARKLGVKKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTE 154

  Fly   430 LA----HELNVDVMAFV-----------------SHLRQEVYSK---------------TGCPCS 458
            :.    .:|..|.:..|                 :|:|..|.|:               |||
  Rat   155 MVEKRLQQLPSDEVPSVTMSGHVYNNQSVNLHSSTHVRLAVGSQIAAEMREAMHNQLGLTGC--- 216

  Fly   459 AGVAGNKLLARMATKEAKPNG---------QFLLDSSNDILAYMAPMSLDLLPGVGSSISHKLKQ 514
            ||||.|||||::.:...|||.         |.|:.|.|.|..         :||:|...:.:|:.
  Rat   217 AGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKE---------MPGIGYKTAKRLEV 272

  Fly   515 AGLNNCGDVQNTTLEKMEKVLGKKLGQNLFQNCRGIDDRPLAYEQIRKTVSAEMNFGIRFTNSVE 579
            .|:|:..|:|...::.:||.||..:.|.:.:...|.|..|:......::.|.|..|. :.::.||
  Rat   273 LGINSVHDLQTFPIKTLEKELGISVAQRIRKLSFGEDKSPVTPSGPPQSFSEEDTFK-KCSSEVE 336

  Fly   580 CEQFLCQLSEEVTKRLVEIRRKARSINLKIM----------VRAAEAPVETSKYMGHGVCDIIN- 633
            .:..:.:|...:..|:....||..:|.|.|.          .|....|....:.:|.|..|.:.
  Rat   337 AKTKIEELLSSLLNRVCHDGRKPHTIRLVIRRYSDKHCNRESRQCPIPSHVIQKLGTGNYDAVPP 401

  Fly   634 -KSSLIKYATDDVNVITTVVLDLMKDADIPPDELRGLGIHLTRLEDANEVRKENNIKEMFGKMSE 697
             ...|:|...:.|||.....|.|             |.:....|:..|..:|        |.|..
  Rat   402 LMEILMKLFRNMVNVKMAFHLTL-------------LSVCFCNLKALNSAKK--------GPMDC 445

  Fly   698 MRKDKPIPQGAVGDKSIGDDKVNKPLVFENKPKPRE-------PRNVLSMLTAAAVSRKSVTEDR 755
            ............|.:|.   || |.:..|:..|.:|       .|.:.|  |....|....|...
  Rat   446 FLTSSLSTTACSGKRSF---KV-KDIHMEDSYKEKEANWDCLPSRRIES--TRRGESPSDATCFP 504

  Fly   756 SQRGTSKPITRPLSLVPK-LDEDVLAQLPEDIRLEVIANR-EEHLCIAEYDGYRSPQYPTLRSPP 818
            .::.||   ..||..:|: :|::|..|||.||:.|:::.: .|:|     .|..|...|...|..
  Rat   505 KEKDTS---DLPLQFLPEGVDQEVFTQLPADIQEEILSGKSRENL-----QGKGSLSCPLHASRG 561

  Fly   819 LLNPYVT--TNVSPLKATD-------------LKPSTSRAAVARLQKRKERKEQEHYIRSDQIVA 868
            :|:.:.|  |....|...|             .:|.||..:.:........|:..:|: .:|:..
  Rat   562 VLSFFSTKQTQAGCLSPRDTLLTGKQASAVSPCEPGTSGLSTSSSSHPSCGKDCSYYV-DNQLKD 625

  Fly   869 DYIDDLP--------DFVNPHILKLISHPVEMPELLM-----GDNYKDLL----------NDWVS 910
            :.:...|        ...||.:....|.|....|.|.     .|::|...          ....:
  Rat   626 ERMSQGPTESQGFHFSNTNPAVSVFHSFPNLQSEQLFSTHRTADSHKQTATTSHQGLENREQDSA 690

  Fly   911 REEVPKPNDVD 921
            .|::..|:|:|
  Rat   691 DEKLTFPSDID 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	113/497 (23%)
		Rev1_C	890..985	CDD:213388	8/47 (17%)
Poli	NP_001099607.1	DinP	48..384	CDD:223466	91/399 (23%)
Poli	NP_001099607.1	PolY_Pol_iota	51..431	CDD:176457	102/456 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810