DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rev1 and Polk

DIOPT Version :9

Sequence 1:	NP_612047.1	Gene:	Rev1 / 38079	FlyBaseID:	FBgn0035150	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_036178.1	Gene:	Polk / 27015	MGIID:	1349767	Length:	852	Species:	Mus musculus

Alignment Length:	965	Identity:	181/965 - (18%)
Similarity:	322/965 - (33%)	Gaps:	338/965 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 KPKDN---------GANESKSDVEP-PKDKA-EVEVDSTK------DETQMELGGILKNLQQAVA 183
            |.|||         |.|::|:.:|. .|:|. ::.:::||      :|.:.|     |.:.|.:.
Mouse     5 KEKDNFKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKE-----KQVNQRIE 64

  Fly   184 TSPEKEASASESKITNLSTTSNNSTTARTAADPNFLSEFYKNSRLHHIATLGAGFKQYVCRLRQK 248
            ...:::|          ..||.....|:...| .|..|..:|..|::.
Mouse    65 NMMQQKA----------QITSQQLRKAQLQVD-KFAMELERNRNLNNT----------------- 101

  Fly   249 HGTQGFPKRETLKSLANSHHNCLERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHSKGGNAATD 313
                                      ::|:|||.|:.:|.:|..|||:..||||.
Mouse   102 --------------------------IVHVDMDAFYAAVEMRDNPELKDKPIAVG---------- 130

  Fly   314 VPVHPQADRKAELELFAQRFEHHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGM--F 376
                                                     |:|.:|:.:|.||..|:|..|  |
Mouse   131 -----------------------------------------SMSMLATSNYHARRFGVRAAMPGF 154

  Fly   377 VGQALKLCPELKTIPYDFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTD------------ 429
            :  |.:|||:|..:|.:|:.|:.|:..:.:.:|:|..|..|:|.||.::.:|.
Mouse   155 I--AKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQDWPEDK 217

  Fly   430 -----------------------LAHELNVDVMAF------------------------------ 441
                                   ..:|.::..:.|
Mouse   218 RRYFIKMGNYLKIDTPRQEANELTEYERSISPLLFEDSPPDLQPQGSPFQLNSEEQNNPQIAQNS 282

  Fly   442 ----------VSHLRQEVYSKTGCPCSAGVAGNKLLARMATKEAKPNGQF-LLDSSNDILAYMAP 495
                      |..:|..:..||....|||:|.|.:||::.:.:.|||||: :|.|.:.::.::..
Mouse   283 VVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPSRSAVMDFIKD 347

  Fly   496 MSLDLLPGVGSSISHKLKQAGLNNCGDVQNTTLEKMEKVLGKKLGQN----LFQNCRGIDDRPLA 556
            :.:..:.|:|......|...|:..|     |.|.:...:|.....:.    ......|:....||
Mouse   348 LPIRKVSGIGKVTEKMLMALGIVTC-----TELYQQRALLSLLFSETSWHYFLHIALGLGSTDLA 407

  Fly   557 YEQIRKTVSAEMNFGIRFTNSVE----CEQFLCQLSEEVTK-----RLVEIRRKARSINLKIMVR 612
            .:..||::|.|..|. ..:.:.|    |::...:|:.::.|     |.|.|  |.:::|.::..|
Mouse   408 RDGERKSMSVERTFS-EISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTI--KLKNVNFEVKTR 469

  Fly   613 AAEAPVETSKYMGHGVCDIINKSSLIKYATDDVNVITTVVLDLMKDADIP-PDELRGLGIHLTRL 676
            |:..|...|                   ..:::..|...:|....:...| |..||.:|:.::..
Mouse   470 ASTVPAAIS-------------------TAEEIFAIAKELLRTEVNVGSPHPLRLRLMGVRMSTF 515

  Fly   677 EDANEVRKENNIKEMFGKMSEMRKDKPIPQGAVGDKSIGD--DKVNKPLVFENKPKPREPRNVLS 739
              ::|..:::..:.:.|.:.         .|.....|.||  ||.:|    ....||.|..:..|
Mouse   516 --SSEDDRKHQQRSIIGFLQ---------AGNQALSSTGDSLDKTDK----TELAKPLEMSHKKS 565

  Fly   740 MLTAAAVSRKSVTEDRSQRGT----SKPITRPLSLVPKLDEDVLAQLPEDIRLEVIANREE---- 796
            ........|.|..:|.|:..|    :..|..|...:.||.|.          .|...|..:
Mouse   566 FFDKKRSERISNCQDTSRCKTAGQQALQILEPSQALKKLSES----------FETSENSNDCQTF 620

  Fly   797 --HLCIAEYDGYRSPQYPTLRSPPLLNPYVTTNVSPLKATDLKPSTSRAAVARLQKRKERKEQEH 859
              .:|..|.:|.         |....|.:|...:.       .||||           |..:...
Mouse   621 ICPVCFREQEGV---------SLEAFNEHVDECLD-------GPSTS-----------ENSKISC 658

  Fly   860 YIRSDQIVADYIDDLPDFVNPHILKLISHPVEMPELLMGDNY--------------KDLLNDWVS 910
            |..:........:|    |:|.|........|..|:.:.|..              .|.|.:..|
Mouse   659 YSHASSADIGQKED----VHPSIPLCEKRGHENGEITLVDGVDLTGTEDRSLKAARMDTLENNRS 719

  Fly   911 REEVP----KPNDVDLILKQVSRMIKNDQL----DHVCDVMKYWCRIINMKRSSS 957
            :||.|    |...:.|..:.:|.:.:.|.:    |.|.......|.:.|:::.:|
Mouse   720 KEECPDIPDKSCPISLENETISTLSRQDSVQPCTDEVVTGRALVCPVCNLEQETS 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	101/549 (18%)
		Rev1_C	890..985	CDD:213388	18/90 (20%)
Polk	NP_036178.1	PolY_Pol_IV_kappa	103..513	CDD:176459	97/489 (20%)
		PRK02406	107..521	CDD:235035	96/495 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..273		1/20 (5%)
		ZnF_Rad18	620..645	CDD:128973	6/33 (18%)
		ZnF_Rad18	761..787	CDD:128973	3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..852
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810