DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rev1 and Poli

DIOPT Version :9

Sequence 1:	NP_612047.1	Gene:	Rev1 / 38079	FlyBaseID:	FBgn0035150	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_036102.2	Gene:	Poli / 26447	MGIID:	1347081	Length:	737	Species:	Mus musculus

Alignment Length:	808	Identity:	170/808 - (21%)
Similarity:	298/808 - (36%)	Gaps:	252/808 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 AGFKQYVCRLRQKHGTQGFPKRETLKSLANSHHNCLERYVMHIDMDCFFVSVGLRTRPELRGLPI 300
            ||..:.||       :||.|.:     :::|      |.::|:|:|||:..|.:.:.|||:..|:
Mouse    29 AGSSRAVC-------SQGPPTQ-----ISSS------RVIVHVDLDCFYAQVEMISNPELKDRPL 75

  Fly   301 AVTHSKGGNAATDVPVHPQADRKAELELFAQRFEHHFHDGDKAEKVRSGFDKKMSLSEIASCSYE 365
            .|                           .|::                        .:.:|:||
Mouse    76 GV---------------------------QQKY------------------------LVVTCNYE 89

  Fly   366 AREKGIRNGMFVGQALKLCPELKTI-PYDFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTD 429
            ||:.|:|..|.|..|.:.||:|..: ..|...|:|:::.:.:.:.:::..:|.:..||.||:||:
Mouse    90 ARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTE 154

  Fly   430 LAHEL----------NVDVMAFV-----------------------SHLRQEVYSKTGCPCSAGV 461
            :..:.          :|.|...|                       :.:|:.:|::.|....|||
Mouse   155 MVEKRLQQLPSEEVPSVTVFGHVYNNQSVNLHNIMHRRLVVGSQIAAEMREAMYNQLGLTGCAGV 219

  Fly   462 AGNKLLARMATKEAKPNG---------QFLLDSSNDILAYMAPMSLDLLPGVGSSISHKLKQAGL 517
            |.|||||::.:...|||.         |.|:.|.|.|..         :||:|...:.:|:..|:
Mouse   220 APNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKE---------IPGIGYKTAKRLEVLGI 275

  Fly   518 NNCGDVQNTTLEKMEKVLGKKLGQNLFQNCRGIDDRPLAYEQIRKTVSAEMNFGIRFTNSVECEQ 582
            |:..|:|...::.:||.||..:.|.:.|...|.|..|:......::.|.|..|. :.::.||.:.
Mouse   276 NSVHDLQTFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTFK-KCSSEVEAKA 339

  Fly   583 FLCQLSEEVTKRLVEIRRKARSINLKIM----------VRAAEAPVETSKYMGHG-------VCD 630
            .:.:|...:..|:.:..||..::.|.|.          .|....|....:.:|.|       :.|
Mouse   340 KIEELLSSLLTRVCQDGRKPHTVRLVIRRYSDKHCNRESRQCPIPSHVIQKLGTGNHDSMPPLID 404

  Fly   631 IINKSSLIKYATDDVNVITTVVLDLM----------KDADIPPDELRGLGIHLTRLE-DANEVRK 684
            |     |:|...:.|||.....|.||          ..|...|     :..:||.|. .|...::
Mouse   405 I-----LMKLFRNMVNVKMPFHLTLMSVCFCNLKALSSAKKGP-----MDCYLTSLSTPAYTDKR 459

  Fly   685 ENNIKEMFGKMSEMRKDKP---IPQGAVGDKSIGDDKVNKPLVFENKPKPREPRNVLSMLTAAAV 746
            ...:|:...:.|...|:..   :|...:.....|:                      |.|.|...
Mouse   460 AFKVKDTHTEDSHKEKEANWDCLPSRRIESTGTGE----------------------SPLDATCF 502

  Fly   747 SRKSVTEDRSQRGTSKPITRPLSLVPK-LDEDVLAQLPEDIRLEVIANR-EEHLCIAEYDGYRSP 809
            .::..|.|           .||..:|: :|::|..|||.||:.|:::.: .|:|     .|..|.
Mouse   503 PKEKDTSD-----------LPLQALPEGVDQEVFKQLPADIQEEILSGKSRENL-----KGKGSL 551

  Fly   810 QYPTLRSPPLLNPYVT-----TNVSP----------LKATDLKPSTSRAAVARLQKRKERKEQEH 859
            ..|...|..:|:.:.|     :.:||          ..|:..:|.||..:..........|:..:
Mouse   552 SCPLHASRGVLSFFSTKQMQASRLSPRDTALPSKRVSAASPCEPGTSGLSPGSTSHPSCGKDCSY 616

  Fly   860 YIRSDQIVADYIDDLP--------DFVNPHILKLISHPVEMPELLMG-----DNYKDL------- 904
            ||.| |:..:.....|        ...||.:....|.|....|.|..     |::|..
Mouse   617 YIDS-QLKDEQTSQGPTESQGCQFSSTNPAVSGFHSFPNLQTEQLFSTHRTVDSHKQTATASHQG 680

  Fly   905 -----------LNDWVSREEVPKPNDVD 921
                       |:.  :.|::|.|.|:|
Mouse   681 LESHQGLESRELDS--AEEKLPFPPDID 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	113/509 (22%)
		Rev1_C	890..985	CDD:213388	10/55 (18%)
Poli	NP_036102.2	PolY_Pol_iota	51..431	CDD:176457	100/445 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810