DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rev1 and polh-1

DIOPT Version :9

Sequence 1:	NP_612047.1	Gene:	Rev1 / 38079	FlyBaseID:	FBgn0035150	Length:	995	Species:	Drosophila melanogaster
Sequence 2:	NP_497480.2	Gene:	polh-1 / 175337	WormBaseID:	WBGene00018721	Length:	584	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	127/577 - (22%)
Similarity:	213/577 - (36%)	Gaps:	186/577 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 LERYVMHIDMDCFFVSVGLRTRPELRGLP-IAVTHSKGGNAATDVPVHPQADRKAELELFAQRFE 334
            ::|.:..||||||:..|..|..|.|.|.| |.|.||:.|
Worm     1 MKRVISLIDMDCFYAQVEQRDNPSLWGQPVIVVQHSRQG-------------------------- 39

  Fly   335 HHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQALKLCPELKT--IPY----- 392
                       :..|         |.:.|||||..|::.||.|.:|...||::..  :|.
Worm    40 -----------IEGG---------ILAVSYEARPFGVKRGMTVAEAKLKCPQISICHVPIGEYVD 84

  Fly   393 --DFEGYKEVAFTLYDTVAQY--TLNIEAVSCDEMFVEL-------------------------- 427
              |.:.|::.:..::..:..|  .:.||..|.||.|::|
Worm    85 KADIQKYRDASAEVFRVLNNYDSQIIIEKASVDEAFLDLSAYTNQKLQELRENEGLEEFLQAAIT 149

  Fly   428 ----TDLA--------HELNVDVM--------------------AFVSHLRQEVYSKTGCPCSAG 460
                |.||        ..|..||:                    ..|..:||:::.:|...||||
Worm   150 YLPTTHLATGEDVKENEHLREDVLLEYIENARNCTENLLLLIAAVTVEQIRQQIHEETQFFCSAG 214

  Fly   461 VAGNKLLARMATKEAKPNGQFLLDSSNDILAYMAPMSLDLLP-----GVGSSISHKLKQAGLNNC 520
            |..||::|::.....||..|.|:.     ..|:..: |.|.|     |.|..:.::::
Worm   215 VGNNKMMAKLVCARHKPRQQTLIP-----WFYVREI-LRLTPIGDVRGFGGKMGNRIQ------- 266

  Fly   521 GDVQNTTLEKMEKVLGKKLGQ--NLFQN--------CRGIDDRPLAYEQIRKTVSAEMNF--GIR 573
             ::.|.||  |.::|...:.|  ..|.|        ..|..|.|:...:...:::...||  .:.
Worm   267 -EMLNITL--MGELLEVDISQLIETFPNQHEYLRSVAEGHCDEPVRPRKESSSIAVSKNFPGKLS 328

  Fly   574 FTNSVECEQFLCQLSEEVTKRL----VEIRRKARSINLKIMVRAAEAPVETSKYMGH-------- 626
            ..:.:|.:::|..|::|:.|||    .|.:|.|.::...::....: |.:|.|...:
Worm   329 IRSVLELKKWLDGLTKELAKRLATDQAENKRTAENLVYSLLTEDGK-PQKTLKITSYHPDTLFEQ 392

  Fly   627 --GVCDIINKSSLIKYATDDVNVITTVVLDLMKDA-----DIPPDELRGLGIHLTRLEDANEVRK 684
              .....:||::..|  .:|....|..:|::...|     .||... |.:...|...:.....||
Worm   393 IWAAMKGLNKTNATK--NEDSGPWTPPILNISLSATRFQPGIPAQN-RSIHEWLYEKKTRKSRRK 454

  Fly   685 -----ENNIKE--MFGKMSE-MRKDKPIPQ--GAVGD----KSIGDDKVNKPLVFEN 727
                 ||:.:|  :|.:..| ::|..|.|:  |..||    .|..||.|.:|...:|
Worm   455 AAIYDENDGREDVIFVEPPEKLKKPNPTPKSTGTDGDFIVLGSDSDDDVVQPKTDDN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rev1	NP_612047.1	BRCT_Rev1	39..121	CDD:349351
		PolY_Rev1	218..676	CDD:176455	108/510 (21%)
		Rev1_C	890..985	CDD:213388
polh-1	NP_497480.2	PolY	7..426	CDD:391962	102/483 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0389
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810