DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gale and GAL10

DIOPT Version :9

Sequence 1:	NP_001246537.1	Gene:	Gale / 38076	FlyBaseID:	FBgn0035147	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_009575.1	Gene:	GAL10 / 852307	SGDID:	S000000223	Length:	699	Species:	Saccharomyces cerevisiae

Alignment Length:	350	Identity:	182/350 - (52%)
Similarity:	236/350 - (67%)	Gaps:	16/350 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLVTGGAGYIGSHTVLEMLNAGYNVICVDNLCNA-YSSGAKLPEALSRVQEITGKKVNFYRVDIT 69
            |||||||||||||||:|::..||:.:..|||.|: |.|       ::|::.:|...:.||.||:.
Yeast    14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDS-------VARLEVLTKHHIPFYEVDLC 71

  Fly    70 DREQVRSVFQEHKIDMVAHFAALKAVGESCRIPLQYYHNNMTGTNVLLEAMADNNVFKFVYSSSA 134
            ||:.:..||:|:|||.|.|||.|||||||.:|||:|||||:.||.||||.|...||.|||:||||
Yeast    72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFSSSA 136

  Fly   135 TVYGE----PKFLPVTEEHPTGNCTSPYGKTKYFTEEILKDLCKSDKR-WAVVSLRYFNPVGAHI 194
            ||||:    |..:|:.||.|.|. |:|||.|||..|.||.||..|||: |....||||||:|||.
Yeast   137 TVYGDATRFPNMIPIPEECPLGP-TNPYGHTKYAIENILNDLYNSDKKSWKFAILRYFNPIGAHP 200

  Fly   195 SGRIGEDPNGEPNNLMPYIAQVAVGRRPSLSVYGSDFPTHDGTGVRDYIHIVDLAEGHVKALDKL 259
            ||.|||||.|.||||:||:||||||||..|.::|.|:.:.|||.:|||||:||||:||:.||..|
Yeast   201 SGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHVVDLAKGHIAALQYL 265

  Fly   260 RNIAETGFFA--YNLGTGVGYSVLDMVKAFEKASGKKVNYTLVDRRSGDVATCYADATLADKKLG 322
            ....|.....  :|||:|.|.:|.::..||.||||..:.|.:..||:|||....|....|.::|.
Yeast   266 EAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELK 330

  Fly   323 WKAERGIDKMCEDTWRWQSQNPNGY 347
            |:.|..::..|:|.|:|.::||.||
Yeast   331 WQTELQVEDSCKDLWKWTTENPFGY 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gale	NP_001246537.1	UDP_G4E_1_SDR_e	5..341	CDD:187558	178/342 (52%)
Gale	NP_001246537.1	galE	6..343	CDD:273487	178/344 (52%)
GAL10	NP_009575.1	UDP_G4E_1_SDR_e	14..349	CDD:187558	178/342 (52%)
GAL10	NP_009575.1	galactose_mutarotase_like	376..698	CDD:185696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	328	1.000	Domainoid score	I173
eggNOG	1	0.900	-	-		E1_COG1087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001696
OrthoInspector	1	1.000	-	-		oto99091
orthoMCL	1	0.900	-	-		OOG6_100506
Panther	1	1.100	-	-	LDO	PTHR43725
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1854
SonicParanoid	1	1.000	-	-		X1246
TreeFam	1	0.960	-	-
	10	9.800