DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gale and gal10

DIOPT Version :9

Sequence 1:	NP_001246537.1	Gene:	Gale / 38076	FlyBaseID:	FBgn0035147	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_596858.1	Gene:	gal10 / 2541411	PomBaseID:	SPBPB2B2.12c	Length:	713	Species:	Schizosaccharomyces pombe

Alignment Length:	349	Identity:	179/349 - (51%)
Similarity:	235/349 - (67%)	Gaps:	15/349 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLVTGGAGYIGSHTVLEMLNAGYNVICVDNLCNA-YSSGAKLPEALSRVQEITGKKVNFYRVDIT 69
            :||||||||||||||:|::|.||.||.||||||: |       :|::||:.|..|.:.|:::|:.
pombe     8 ILVTGGAGYIGSHTVIELINHGYKVIIVDNLCNSCY-------DAVARVEFIVRKSIKFFKLDLR 65

  Fly    70 DREQVRSVFQEHKIDMVAHFAALKAVGESCRIPLQYYHNNMTGTNVLLEAMADNNVFKFVYSSSA 134
            |:|.:..:|...||..|.|||||||||||.::||:||.||:.||..||..|.::.|...|:||||
pombe    66 DKEGLAQIFDTFKIKGVIHFAALKAVGESMKLPLEYYDNNICGTITLLNVMREHRVKTVVFSSSA 130

  Fly   135 TVYGE----PKFLPVTEEHPTGNCTSPYGKTKYFTEEILKDLCKSDKRWAVVSLRYFNPVGAHIS 195
            ||||:    ...:|:.|..| .:.|:|||||||..|.|:|||..||..|....||||||:|||.|
pombe   131 TVYGDATRFDNMIPIPESCP-NDPTNPYGKTKYAIENIIKDLHTSDNTWRGAILRYFNPIGAHPS 194

  Fly   196 GRIGEDPNGEPNNLMPYIAQVAVGRRPSLSVYGSDFPTHDGTGVRDYIHIVDLAEGHVKALDKLR 260
            |.:||||.|.||||:|::||||:|||..|.|:|.|:.:||||.:|||||:||||:||:.||:.|.
pombe   195 GLLGEDPLGIPNNLLPFLAQVAIGRREKLLVFGDDYDSHDGTPIRDYIHVVDLAKGHIAALNYLN 259

  Fly   261 NI--AETGFFAYNLGTGVGYSVLDMVKAFEKASGKKVNYTLVDRRSGDVATCYADATLADKKLGW 323
            .|  :|..:..:|||||.|.||.|:..||.|..||.:.|.:|.||:|||....|....|:.:|.|
pombe   260 KINNSEGMYREWNLGTGKGSSVFDIYHAFCKEVGKDLPYEVVGRRTGDVLNLTASPNRANSELKW 324

  Fly   324 KAERGIDKMCEDTWRWQSQNPNGY 347
            |||..|...|.|.|:|..:||.|:
pombe   325 KAELSITDACRDLWKWTIENPFGF 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gale	NP_001246537.1	UDP_G4E_1_SDR_e	5..341	CDD:187558	176/341 (52%)
Gale	NP_001246537.1	galE	6..343	CDD:273487	176/343 (51%)
gal10	NP_596858.1	galE	8..344	CDD:273487	176/343 (51%)
		UDP_G4E_1_SDR_e	8..340	CDD:187558	175/339 (52%)
		galactose_mutarotase_like	376..689	CDD:185696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	332	1.000	Domainoid score	I205
eggNOG	1	0.900	-	-		E1_COG1087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001696
OrthoInspector	1	1.000	-	-		otm47034
orthoMCL	1	0.900	-	-		OOG6_100506
Panther	1	1.100	-	-	LDO	PTHR43725
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1854
SonicParanoid	1	1.000	-	-		X1246
TreeFam	1	0.960	-	-
	10	9.800