DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13893 and SEC14

DIOPT Version :9

Sequence 1:	NP_612042.3	Gene:	CG13893 / 38074	FlyBaseID:	FBgn0035146	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_013796.1	Gene:	SEC14 / 855103	SGDID:	S000004684	Length:	304	Species:	Saccharomyces cerevisiae

Alignment Length:	320	Identity:	85/320 - (26%)
Similarity:	138/320 - (43%)	Gaps:	62/320 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGPLPEISEEQRAILEKFRKQMDDA-LVGTHDDYFLVRWLRARKWNLEAAEKMLRASLKTRAMW 64
            :.|....:...|...|.:.||.::|| .:...||..|:|:|||||::::.|::|.....|.|..:
Yeast    22 LPGTPGNLDSAQEKALAELRKLLEDAGFIERLDDSTLLRFLRARKFDVQLAKEMFENCEKWRKDY 86

  Fly    65 NVDNIEK---WDPPKALQEYLPYGLMGYDNEGSPVLVCPFANFDMWGMMHCVTRFEFQKYLVLLL 126
            ..|.|.:   :|....:.::.|......|.:|.||.      |:..|   .|...|..|  |...
Yeast    87 GTDTILQDFHYDEKPLIAKFYPQYYHKTDKDGRPVY------FEELG---AVNLHEMNK--VTSE 140

  Fly   127 ERFMK-IAYDQSQKHGWR-------ARQLV----VFFDMQDVNLKQYAWRPAAECVISTVKQYEA 179
            ||.:| :.::......:|       |..||    ...|::.:::.      :|..|:|.|:  ||
Yeast   141 ERMLKNLVWEYESVVQYRLPACSRAAGHLVETSCTIMDLKGISIS------SAYSVMSYVR--EA 197

  Fly   180 N------FPELLKMCYIINAPKLFSVAFNIVKKFLDENTTSKIVIYKSGVDRWQEQLFSHVNRKA 238
            :      :||.:...||||||..||.||.:.|.|||..|.|||.|..|.   :|::|...:..:.
Yeast   198 SYISQNYYPERMGKFYIINAPFGFSTAFRLFKPFLDPVTVSKIFILGSS---YQKELLKQIPAEN 259

  Fly   239 FPKAWGGEM-VDRNGDPQCKALMVWGGKLPEELYIDQSSQQSDRDFV--EAQVPKGDKLK 295
            .|..:||:. ||.:.          ||     ||:.......|..::  |.:.|:...:|
Yeast   260 LPVKFGGKSEVDESK----------GG-----LYLSDIGPWRDPKYIGPEGEAPEAFSMK 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13893	NP_612042.3	CRAL_TRIO_N	16..57	CDD:215024	16/41 (39%)
		SEC14	75..246	CDD:238099	51/188 (27%)
		GOLD_2	303..381	CDD:290608
SEC14	NP_013796.1	CRAL_TRIO_N	34..79	CDD:215024	16/44 (36%)
SEC14	NP_013796.1	SEC14	99..269	CDD:214706	52/191 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I1667
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		mtm9225
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890