DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13893 and SEC14L6

DIOPT Version :9

Sequence 1:	NP_612042.3	Gene:	CG13893 / 38074	FlyBaseID:	FBgn0035146	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	XP_016884420.1	Gene:	SEC14L6 / 730005	HGNCID:	40047	Length:	432	Species:	Homo sapiens

Alignment Length:	429	Identity:	122/429 - (28%)
Similarity:	215/429 - (50%)	Gaps:	50/429 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGPLPEISEEQRAILEKFRKQMDDAL--VGTHDDYFLVRWLRARKWNLEAAEKMLRASLKTRAM 63
            |||.:.::|..|...|.:||:.:.|.|  :...|||||:|||:||.::|:.:|.|||..::.|..
Human     4 MSGQVGDLSPSQEKSLAQFRENIQDVLSALPNPDDYFLLRWLQARSFDLQKSEDMLRKHMEFRKQ 68

  Fly    64 WNVDNIEKWDPPKALQEYLPYGLMGYDNEGSPVLVCPFANFDMWGMMHCVTRFEFQKYLVLLLER 128
            .::.||..|.||:.::.|...|:.|:|.|||||......:.|..|::...::.|..:......|.
Human    69 QDLANILAWQPPEVVRLYNANGICGHDGEGSPVWYHIVGSLDPKGLLLSASKQELLRDSFRSCEL 133

  Fly   129 FMKIAYDQSQKHGW--------------------------------RARQLVVFFDMQDVNLKQY 161
            .::....||||..|                                |..:::..|.::.:.|:.
Human   134 LLRECELQSQKPHWTRGTGISAPLDRRGNCNTAIWPPMDRHKELGKRVEKIIAIFGLEGLGLRD- 197

  Fly   162 AWRPAAECVISTVKQYEANFPELLKMCYIINAPKLFSVAFNIVKKFLDENTTSKIVIYKSGVDRW 226
            .|:|..|.:.......|||:||:||...::.|||||:||||:||.::.|.|..|:||..   |.|
Human   198 LWKPGIELLQEFFSALEANYPEILKSLIVVRAPKLFAVAFNLVKSYMSEETRRKVVILG---DNW 259

  Fly   227 QEQLFSHVNRKAFPKAWGGEMVDRNGDPQCKALMVWGGKLPEELYI-DQSSQQSDRDFVEAQVPK 290
            :::|...::....|..:||.|.|.:|:|:|...:.:||::|:..|: .|...|.:.   ...|.:
Human   260 KQELTKFISPDQLPVEFGGTMTDPDGNPKCLTKINYGGEVPKSYYLCKQVRLQYEH---TRSVGR 321

  Fly   291 GDKLKLHFKVNVEEQKILSWEFRTFDYDIKFGIYSVDDKTGEKR-----SEVPLGTVYSNEM-DE 349
            |..|::..:: :....:|.|:|.:...||.||:: :..|.||::     :||.....|:..| .|
Human   322 GSSLQVENEI-LFPGCVLRWQFASDGGDIGFGVF-LKTKMGERQRAREMTEVLPSQRYNAHMVPE 384

  Fly   350 IGYISTRPNTTYTVVFDNSASYLRSKKLRYWVDLISEEE 388
            .|.::.....:|.:.|.|:.|.:.||::.|.|:::..::
Human   385 DGILTCLQAGSYVLRFYNTYSLVHSKRISYTVEVLLPDQ 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13893	NP_612042.3	CRAL_TRIO_N	16..57	CDD:215024	20/42 (48%)
		SEC14	75..246	CDD:238099	53/202 (26%)
		GOLD_2	303..381	CDD:290608	23/83 (28%)
SEC14L6	XP_016884420.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151944
Domainoid	1	1.000	63	0.304	Domainoid score	I10238
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3520
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52454
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		otm41197
orthoMCL	1	0.900	-	-		OOG6_102488
Panther	1	1.100	-	-	O	PTHR23324
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770