DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13893 and sec14l8

DIOPT Version :9

Sequence 1:	NP_612042.3	Gene:	CG13893 / 38074	FlyBaseID:	FBgn0035146	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001093463.1	Gene:	sec14l8 / 558964	ZFINID:	ZDB-GENE-060526-180	Length:	395	Species:	Danio rerio

Alignment Length:	409	Identity:	125/409 - (30%)
Similarity:	218/409 - (53%)	Gaps:	23/409 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGPLPEISEEQRAILEKFRKQMDDAL--VGTHDDYFLVRWLRARKWNLEAAEKMLRASLKTRAM 63
            |||.:.::|.:|...|.:||:::.|.|  ..:..|:||:||||||.:||:.:|.|||..::.|..
Zfish     1 MSGRVGDLSVKQAEALAQFREKVQDVLPQCPSQSDHFLLRWLRARNFNLQKSEAMLRKHIEFRKH 65

  Fly    64 WNVDNI-EKWDPPKALQEYLPYGLMGYDNEGSPVLVCPFANFDMWGMMHCVTRFEFQKYLVLLLE 127
            ..||.| .:|..|:.:.:||..|:.|:|.|||||........|..|:||..::.:..|..|...|
Zfish    66 MKVDTITTEWQVPEVIDKYLSGGMCGHDREGSPVWYDVIGPLDPKGLMHSASKQDLIKSKVRDCE 130

  Fly   128 RFMKIAYDQSQKHGWRARQLVVFFDMQDVNLKQYAWRPAAECVISTVKQYEANFPELLKMCYIIN 192
            ...|....||::.|.....:.:.:|.:.:.:| :.::||.|.....:..:|.|:||.||..::|.
Zfish   131 ILQKDCDRQSERLGRNIESITMVYDCEGLGMK-HLYKPAIETYGEVLTMFEDNYPEGLKRLFVIK 194

  Fly   193 APKLFSVAFNIVKKFLDENTTSKIVIYKSGVDRWQEQLFSHVNRKAFPKAWGGEMVDRNGDPQCK 257
            |||||.||:|:||.||.|:|..|:::..|   .|||.|..:::.:..|..:||::.|.:|||:|:
Zfish   195 APKLFPVAYNLVKHFLSEDTRRKVIVLGS---NWQEVLQKYIDPEELPAYYGGKLTDPDGDPKCR 256

  Fly   258 ALMVWGGKLPEELYIDQSSQQSDRDFVEA-QVPKGDKLKLHFKVNVEEQKILSWEFRTFDYDIKF 321
            ..:.:|.::|:..|:..|.:.   |:.:: .:.:|...::.::: :.....|.|:|.....||.|
Zfish   257 TRITFGSEIPKSYYVRDSIKV---DYEQSVSIGRGSSHQMEYEL-IAPNCALRWQFSCDGADIGF 317

  Fly   322 GIYSVDD-----KTGEKRSEVPLGTVYSNEMDEIGYISTRPNTTYTVVFDNSASYLRSKKLRYWV 381
            |:|....     |.||.|..||.....::.:.|.|.::......|.:.|||:.|..:||.:::.|
Zfish   318 GVYLKKKMGERMKAGEMREIVPNQRYNAHLVPEDGSLTCPEPGVYVLRFDNTYSVFQSKTVKFTV 382

  Fly   382 DLISEEEEGISELTTQMDN 400
            :::      :.....|.||
Zfish   383 EVL------LPSQVNQSDN 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13893	NP_612042.3	CRAL_TRIO_N	16..57	CDD:215024	20/42 (48%)
		SEC14	75..246	CDD:238099	56/170 (33%)
		GOLD_2	303..381	CDD:290608	23/82 (28%)
sec14l8	NP_001093463.1	CRAL_TRIO_N	13..59	CDD:215024	20/45 (44%)
		SEC14	78..246	CDD:214706	57/171 (33%)
		GOLD_2	304..382	CDD:290608	23/77 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586533
Domainoid	1	1.000	54	1.000	Domainoid score	I11246
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3678
OMA	1	1.010	-	-		QHG52454
OrthoDB	1	1.010	-	-		D1133487at2759
OrthoFinder	1	1.000	-	-		FOG0000197
OrthoInspector	1	1.000	-	-		otm26332
orthoMCL	1	0.900	-	-		OOG6_102488
Panther	1	1.100	-	-	LDO	PTHR23324
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1304
SonicParanoid	1	1.000	-	-		X1090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800