DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13893 and Ttpa

DIOPT Version :9

Sequence 1:	NP_612042.3	Gene:	CG13893 / 38074	FlyBaseID:	FBgn0035146	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_056582.1	Gene:	Ttpa / 50500	MGIID:	1354168	Length:	278	Species:	Mus musculus

Alignment Length:	265	Identity:	61/265 - (23%)
Similarity:	115/265 - (43%)	Gaps:	60/265 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PL--PEISEEQRAILEKFRKQMDDALVGTHDDYFLVRWLRARKWNLEAAEKMLRASLKTRAMWNV 66
            ||  |.::|.:|.:.|....|....|.    |.||:|:||||.::|:.|.::::
Mouse    22 PLLQPGLAELRRRVQEAGVPQTPQPLT----DAFLLRFLRARDFDLDLAWRLMK----------- 71

  Fly    67 DNIEKW--DPPKALQEYLPYGLMGY------------DNEGSPVLVCPFANFDMWGMMHCVTRFE 117
             |..||  :.|:...:..|..::|.            |:.||.||:...|.:|    ....|.::
Mouse    72 -NYYKWRAECPELSADLRPRSILGLLKAGYHGVLRSRDSTGSRVLIYRIAYWD----PKVFTAYD 131

  Fly   118 FQKYLVLLLERFMKIAYDQSQKHGWRARQLVVFFDMQDVNLKQYAWR--PAAECVISTVKQYEA- 179
            .  :.|.|:...:.:...::|::|.:|     .||::       .|:  .|.:...|..|:..|
Mouse   132 V--FRVSLITSELIVQEVETQRNGVKA-----IFDLE-------GWQVSHAFQITPSVAKKIAAV 182

  Fly   180 ---NFPELLKMCYIINAPKLFSVAFNIVKKFLDENTTSKIVIYKSGVDRWQEQLFSHVNRKAFPK 241
               :||..::..::||.|.:|...|:::|.||.|....:|.::.:.......|.|..:    .|:
Mouse   183 LTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHLHGNNYKSSMLQHFPDI----LPR 243

  Fly   242 AWGGE 246
            .:||:
Mouse   244 EYGGK 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13893	NP_612042.3	CRAL_TRIO_N	16..57	CDD:215024	13/40 (33%)
		SEC14	75..246	CDD:238099	39/188 (21%)
		GOLD_2	303..381	CDD:290608
Ttpa	NP_056582.1	CRAL_TRIO_N	25..73	CDD:215024	16/63 (25%)
		CRAL_TRIO	99..248	CDD:279044	36/170 (21%)
		Phosphatidylinositol 3,4-bisphosphate binding. /evidence=ECO:0000269\|PubMed:23599266, ECO:0007744\|PDB:3W67	190..192		0/1 (0%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000269\|PubMed:23599266, ECO:0007744\|PDB:3W68	208..211		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810