DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13893 and CLVS1

DIOPT Version :9

Sequence 1:	NP_612042.3	Gene:	CG13893 / 38074	FlyBaseID:	FBgn0035146	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_775790.1	Gene:	CLVS1 / 157807	HGNCID:	23139	Length:	354	Species:	Homo sapiens

Alignment Length:	266	Identity:	60/266 - (22%)
Similarity:	118/266 - (44%)	Gaps:	38/266 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SGPLPEISEEQRA-------ILEKFRKQMDDALVG-------THDDYFLVRWLRARKWNLEAAEK 52
            :|..||..|:.|.       :|.:..:|:.|.::.       ..||.|::|:|||||::...|.:
Human    28 AGLSPETIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFR 92

  Fly    53 MLRASLKTRAMWNVD---NIEKWDP--PKALQEYLPYGLMGYDNEGSPVLVCPFANFDMWGMMHC 112
            :|....:.|.: |:|   |.:..||  .:||.:..|..|...|:.|..:|:...||:|.
Human    93 LLAQYFQYRQL-NLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQ------ 150

  Fly   113 VTRFEFQKYL-VLLLERFMKIAYDQSQKHGWRARQLVVFFDMQDVNLKQYAWRPAAECVISTVKQ 176
             :|..|...| .:||...:.|...:.|.:|:     ::..|..:.:.|| |.:.....:...::.
Human   151 -SRNSFTDILRAILLSLEVLIEDPELQINGF-----ILIIDWSNFSFKQ-ASKLTPSILKLAIEG 208

  Fly   177 YEANFPELLKMCYIINAPKLFSVAFNIVKKFLDENTTSKIVIYKSGVDRWQEQLFSHVNRKAFPK 241
            .:.:||......:.:|.|......:.::|.||.:.|..:|.::.:.::    .|...::.:..|.
Human   209 LQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLN----SLHQLIHPEFLPS 269

  Fly   242 AWGGEM 247
            .:||.:
Human   270 EFGGTL 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13893	NP_612042.3	CRAL_TRIO_N	16..57	CDD:215024	14/47 (30%)
		SEC14	75..246	CDD:238099	34/171 (20%)
		GOLD_2	303..381	CDD:290608
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	13/45 (29%)
		CRAL_TRIO	125..274	CDD:306996	32/165 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810