Protein Alignment MED14 and SWP

DIOPT Version :10

• Sequence 1: NP_728534.2
• Gene: MED14 / 38073
• FlyBaseID: FBgn0035145
• Length: 1555
• Species: Drosophila melanogaster
• Sequence 2: NP_187125.1
• Gene: SWP / 819634
• AraportID: AT3G04740
• Length: 1703
• Species: Arabidopsis thaliana
• Alignment Length: 1666
• Identity: 347/1666 - (20%)
• Similarity: 593/1666 - (35%)
• Gaps: 489/1666 - (29%)

  Fly    34 TMSMSVLIDFIIQRTYHELTVLAELLPRK-----TDMERKVEIYNYAARTRHLFTRLNALVKWGN 93
            |:..|.|:....:.::   ....||:.:.     :|.|:||.:..|.|:|:....|||||.||..
plant     8 TVDFSALVGRAAEESF---LSFKELVDKSKSTELSDTEKKVSLLKYVAKTQQRMLRLNALAKWCK 69

  Fly    94 SVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTC 158
            .|..::....:.|.|...::.|.:.||.|..| .|.|.:||.|.:.:|:|||:|.||:|.|||.|
plant    70 QVPLINYFQDLGSTLSAHDICFTQAADSLFFM-HEGLQQARAPVYDVPSAVEILLTGSYQRLPKC 133

  Fly   159 IRERIVPADAITPAEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVM 223
            : :.:....::...:::..|.:|..:::.:|:...|..::.|.:|..|.||..|..||.|.:|:.
plant   134 L-DDVGMQSSLDEHQQKPALRKLEVLVRSKLLEITLPKEITEVKISKGTVTLSVDGEFKVLVTLG 197

  Fly   224 GDNPTVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQL---IQARLVENPNALSEVYNCLHYF 285
            .......||:|.:|:||.:: :|..|     |:|...|.|   ::.|:....|..:.:|..||..
plant   198 YRGHLSMWRILHLDLLVGER-SGPIK-----LEVTRRHILGDDLERRMSVAENPFTILYAVLHEL 256

  Fly   286 CQSLQLEVLYTQTLRL---------NYERLDDNNIT----------VEEYVPGVKLTVSYWRD-- 329
            |.::.::.:..|...|         .::.:.|...|          |....||:||  .||.|
plant   257 CVAIVMDTVIRQVRALLQGRWKDAIRFDLISDTGTTPANQEGEADSVSLRTPGMKL--FYWSDSD 319

  Fly   330 ------LKSELGYRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVY 388
                  :|.|.|..|.::...|       ...:..|..||:....|::.    :.:|:|::..:.
plant   320 KNSGPFIKIEPGSDLQIKCSHS-------TFVIDPLTGKEAEFSLDQSC----IDVEKLLLKAIC 373

  Fly   389 IRSVSRLSDLKLE---------------FQAFLKD--------VDCEFNLQGTPAILTVPVLSPC 430
            ....:||.:::.|               .||.|.:        ||.:..::  |.:|.|....
plant   374 CNRYTRLLEIQKELLRNTRICRTPSDVILQALLDEPGIEGDNMVDSKERVE--PEVLRVRAYG-- 434

  Fly   431 LRAEQIHITIDTHTGMFRCHVPKH-LDCPIMEEMQDCLN-GDRSKLPALL-----SELRFWIT-- 486
              :....:.|:..||.|.....|. |...|:||.:|.|| |..|.:.|.:     |.|.|:..
plant   435 --SSFFTLGINIRTGRFLLQSSKSILTSSILEEFEDALNQGSISAVDAFINLRSKSILHFFAAIG 497

  Fly   487 ---------H----RRCDKTLQHLPATATETLPFLVQPDQEILQPGRHKIYVKLHRH--PNIVLV 536
                     |    .:..|:|  |..::..||.|   ||.|    ..|.:.::|.:.  |...|:
plant   498 KFLGLEVYEHGFGINKVPKSL--LDGSSILTLGF---PDCE----SSHLLLMELEKDFTPLFKLL 553

  Fly   537 VQLKEKTTMPNEME--------YTFHLGFVAYQKDELDVIDDSAMQLVSIVA------------Q 581
            ....:.:..|....        ....:|.:...:|:|::|....::.||..:            |
plant   554 ETQMDGSGKPQSFNDPSNILRAKKIDIGQIRILEDDLNLITSDVVKFVSSFSDAEGINQASGHRQ 618

  Fly   582 P---------------------------------------HSDIPKCYTKLMRLIEFDTFVATHG 607
            |                                       |..:||..:.          |..||
plant   619 PGLVDEALTEMSGSQLSFSSVVDGVFGLQKVTSALMSIDGHGLVPKNLSA----------VTGHG 673

  Fly   608 PGTEVDAEVS--------PHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLA 664
            ....:.:..|        |.:..|...|.:||.|..                ||  :||...|..
plant   674 KAPMLTSYHSDSLYNRQGPLQSSSYNMLSSPPGKGS----------------AM--KKIAISNSD 720

  Fly   665 QTLSKHNIP--HSGLQVEANATSLVLKILALPQPGKTT--FATQQQQQQGAPAVAGENKPSGTSG 725
            |.||....|  .:|..|..:.:.||.:....|.|...|  .||    ....|.:..:.||...|.
plant   721 QELSLILSPSLSTGNGVSESGSRLVTESSLSPLPLSQTADLAT----SSAGPLLRKDQKPRKRSA 781

  Fly   726 LPKIDSHVWDDLMRRVLSISI---------RSQTNKNSQ---VRIWVVEFVFYSTPLQSSHPKEQ 778
                     .||:|.:.|:.:         |.:|::..|   |:.|.......||.:.:
plant   782 ---------SDLLRLIPSLQVVEGVASPNKRRKTSELVQSELVKSWSPASQTLSTAVST------ 831

  Fly   779 GSRRTVYLTYEQANYDFSKTVEDLLNDWSKIVYLYTLVYDFAEQLLN----KRLSLCDMLVVKSY 839
             |.:|:..:|.....:.:|      .:....|::|.|::......|:    |..|..:.|.::..
plant   832 -STKTIGCSYGNLIAEANK------GNAPSSVFVYALLHVVRHSSLSIKHAKLTSQMEALDIQYV 889

  Fly   840 SYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNGHSMMRDQLAQHLNQQHSITQI--- 901
            ..|.|       ::...:|:       |||.|                 ||:.:.||...|:
plant   890 EEMGL-------RDAFSDIW-------FRLPF-----------------AQNDSWQHICLQLGRP 923

  Fly   902 ------AQILHETYNPLSSIAK-LPVLPF-LGIP-------------RPQVPVLSF-CVLAQS-- 942
                  .:|..:.:..|..:.| ....|: .|:.             .|:..|||: .|.|.|
plant   924 GSMCWDVKINDQHFRDLWELQKGSKTTPWGSGVHIANSSDVDSHIRYDPEGVVLSYQSVEADSIK 988

  Fly   943 ---PCLIRLTYQAVYCLELRFRANRLVSIR-DGASSRFERNVVEEFT--------PIQGLKAF-- 993
               ..:.||:...::.|.:|    :|:.|: |..:.....|...:.:        |:...:||
plant   989 KLVADIQRLSNARMFSLGMR----KLLGIKPDEKTEECSANSTMKGSTGGKGSGEPVDRWRAFKI 1049

  Fly   994 ----------------LSKYVDE-SAVYRGRASHEDDNPLSP--MGMEDNFGGPSSVAGVSA--- 1036
                            |:::|.| .:...|...|...:.|.|  ..:||...|    |.|.:
plant  1050 EAVGLTSLWFSFGSGVLARFVVEWESGKDGCTMHVSPDQLWPHTKFLEDFING----AEVESLLD 1110

  Fly  1037 -----GGSSPFLGTGMRGPQSPRDSGLRFPAPHTPPSSSN--------------PHTPASPHPSA 1082
                 .|....|....|..::...:|:    |..|.::|:              |.|.|:|:
plant  1111 CIRLTAGPLHALAAATRPARASTATGM----PVVPATASSRQSNQIQQTQGIIAPSTLAAPN--- 1168

  Fly  1083 GAGGGSGPQGHGNFNLTSPPAP-----H------MPHPSPSGLMPSSPLNPQPSPHMVHSPGP-- 1134
             |.|.|.....||...:|.|:|     |      ....|..|::|||.|   |....|...||
plant  1169 -ATGQSASATSGNTVASSAPSPLGGGFHGVAMLAAAGRSGPGIVPSSLL---PIDVSVVLRGPYW 1229

  Fly  1135 -NTLYMQSHQ-DSPFTAMSPANNNW--PGSP---------SMPRPSPRP-----------GQSPD 1175
             ..:|.:... |....|   .:..|  |.:|         |:|.|..||           |..|:
plant  1230 IRIIYRKRFAVDMRCFA---GDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPN 1291

  Fly  1176 HKSTGG------GAGVAGGTDR-----GGSRGTLNRPWAGAVPTLLTHEALETLCRPS----PYP 1225
            ...:.|      |.....|.:|     ..:|..:||..:.|..:|:....|.....|.    .:.
plant  1292 LTGSQGATNPNSGNPTVNGVNRVNFSPSSARAAMNRVASVASGSLVVSSGLPVRRTPGTAVPAHV 1356

  Fly  1226 NKDIN----------------VP------DMSPLERFLGCVYMRRQLH---RNI------QSEET 1259
            ..::|                ||      .:..:.::||.:::..||.   |.|      .:|..
plant  1357 RGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKDNEGA 1421

  Fly  1260 LTALNSTEP------GVVLFKVDGLQCQVVLNQMHMQTLHLKVSQLPPMPDKHPPPFQLSQDDLL 1318
            |..|:..:|      |..:|.|...:.|::|..:.::..|.:..|   .........:|:|.::.
plant  1422 LLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQAQQ---NGSSAAAQEELTQSEIG 1483

  Fly  1319 VIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIM 1359
            .|..||..|||:.||..:.:.|...||.||..||::|::::
plant  1484 EICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLI 1524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED14	NP_728534.2	Med14	34..224	CDD:462543	58/194 (30%)
		PHA03247	<1027..1137	CDD:223021	33/145 (23%)
SWP	NP_187125.1	Med14	8..198	CDD:462543	58/194 (30%)