DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED14 and Med14

DIOPT Version :9

Sequence 1:	NP_728534.2	Gene:	MED14 / 38073	FlyBaseID:	FBgn0035145	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_001178656.1	Gene:	Med14 / 317343	RGDID:	1560170	Length:	1459	Species:	Rattus norvegicus

Alignment Length:	1576	Identity:	601/1576 - (38%)
Similarity:	869/1576 - (55%)	Gaps:	196/1576 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAPTPLPLEQM--PGVGGGGGG---------YLPAAQEGGPRINTMS---------MSVLIDFII 45
            |||..|...|:  ||.|||.||         .:||....|..:...:         :|.||:|::
  Rat     1 MAPVQLENHQLIPPGGGGGSGGGGGSSSGSASVPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLL 65

  Fly    46 QRTYHELTVLAELLPRKTDMERKVEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDK 110
            .|.|.||.||.:|||||:|:|||:||..:|:|||.||.||.|||||.|...||:|.:.|.||||:
  Rat    66 HRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQ 130

  Fly   111 QNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKR 175
            |.:|||:|||.||.::|:.||.||||:|.||.|::|||||:|.|||||||::|:|.|.||..||:
  Rat   131 QAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQ 195

  Fly   176 QTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLV 240
            .||.:|||:::|||||..|.||:....:.||||.|.|:.||..:||||||:|.||||||.:::||
  Rat   196 ATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILV 260

  Fly   241 EDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYER 305
            ||||||||::|||.:|:::||||:|:||..:...|.::|||||.||.|||||||::|||.|..||
  Rat   261 EDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRER 325

  Fly   306 LDDNNITVEEYVPGVKLTVSYWRD--LKSELG----YRLTVQSDPSEIGRPLAVVHVPSLGAKES 364
            ..| .:.||.|..|..|::|.|..  |..:.|    :::|::.|.:::.:||.:.|.|.|.|.:|
  Rat   326 WGD-LVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDS 389

  Fly   365 AEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDCEFNLQ---GTPAILTVPV 426
             ::.:||::.:|||:|:|::.:|:.|:..:|.:||    |.|:..:...|..   ..||:: ||:
  Rat   390 -KLVERAMKIDHLSIEKLLIDSVHARAHQKLQELK----AILRSFNANENSSIETALPALI-VPI 448

  Fly   427 LSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPIMEEMQDCLNGDRSKLPALLSELRFWITHRRCD 491
            |.||..:|.:||.:|.|:|||:..: ..||...:|:|:..||.|..::...:.:|:||:..:||.
  Rat   449 LEPCGNSECLHIFVDLHSGMFQLML-YGLDQATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCK 512

  Fly   492 KTLQHLPATATETLPFLVQPDQEILQPGRHKIYVKLHRHPNIVLVVQLKEKTTMPNEMEYTFHLG 556
            ::::|||...||||.........|....::|:::||.|.|...:||::.|....|.::.|.::
  Rat   513 QSIKHLPTITTETLQLANYATHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYY-- 575

  Fly   557 FVAYQKDELDVIDDSAMQLVSIVAQPH-SDIPKCYTKLMRLIEFDTFVATHGPGTEVDAEVSPHK 620
            |::....:.|  |..||.|:....:.: .|:..| |...:    .|...|....::....|...|
  Rat   576 FMSVSTADRD--DSPAMALLLQQFKDNIQDLMSC-TNTGK----QTRTGTKHKLSDDSCPVECKK 633

  Fly   621 RKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATS 685
            .|.:|:..|             |...|||.|||||..:||:.|...||...|||.|:|||.:..|
  Rat   634 AKRSGETCA-------------FNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFS 685

  Fly   686 LVLKILALPQPGKTTFATQQQQQQGAPAVAGENKPSGTSGLPKIDSHVWDDLMRRVLSISIRSQT 750
            ..:::|.:| |.|              .::.|.:.:               |.|.:|..:.|.|.
  Rat   686 HAIRLLKIP-PCK--------------GISEETQKA---------------LDRSLLDCTFRLQG 720

  Fly   751 NKNSQVRIWVVEFVFYSTPLQSSHPKEQGSRRTVYLTYEQANYD---FSKTVEDLLNDWSKIVYL 812
            ..|   |.||.|.||.:.||..:..:|||..|.||||||....:   ..|.||..|||||.|..|
  Rat   721 RNN---RTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARL 782

  Fly   813 YTLVYDFAEQLLNKRLSLCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTF--VGGM 875
            |..|.:||..|......|.....|:.|:|..|:|.||..|..|.:|.|:.....|.::.  ||..
  Rat   783 YECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPN 847

  Fly   876 SAV-NGHSMMRDQLAQHLNQQHSITQIAQILHETYNPLSSIAKLPVLPFLGI-PRPQVPVLSFCV 938
            |.. |.|:.:..||.:..|:..::.|:.|:|.:|..||::|.|||.:|.||: .|.......|.:
  Rat   848 SGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSI 912

  Fly   939 LAQSPCLIRLTYQAVYCLELRFRANRLVSIRDGASSRFERN-VVEEFTPIQGLKAFLSKYVDESA 1002
            |.||...|||.::.:||:::..|:..:|:|||||.|.|:.: :||.|.|..|||.||:.:||.:.
  Rat   913 LPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQ 977

  Fly  1003 VYRGRASHEDDNPLSPMG--MEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDSGLRFPAPHT 1065
            ..|.|:.:|||||.||:|  |.|     |.::.:......||       |:.|..|| .:|.. :
  Rat   978 DARRRSVNEDDNPPSPIGGDMMD-----SLISQLQPPQQQPF-------PKQPGTSG-AYPLT-S 1028

  Fly  1066 PPSSSNPHTPASPHPSAGAGGGSGPQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVH 1130
            ||:|.  |:..:..||.     ...|..||.:..|.|:..:..|||:..:|:    |.||.|.:
  Rat  1029 PPASY--HSTVNQSPSM-----MHTQSPGNLHAASSPSGALRAPSPASFVPT----PPPSSHGI- 1081

  Fly  1131 SPGPNTLYMQSH----QDSPFTAMSPAN--NNWPGSPSMPRPSPR---PGQSP------------ 1174
            |.||...:...|    ..||:|.:||:.  .||||||.:..|||.   ||.||
  Rat  1082 SIGPGASFASPHGALDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDV 1146

  Fly  1175 DHKSTGGGAGVAGGTDRGGSRGTLNRPWAGAVPTLLTHEALETLCRPSPYPNKDINVPDM----- 1234
            .|....|.:.....|:....|....|.||.::||:|||.||..|..|||.|..   ||.:
  Rat  1147 SHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGL---VPGLAGSYL 1208

  Fly  1235 -SPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVVLNQMHMQTLHLKVSQ 1298
             ||||||||.|.|||.|.|.|| :|||..:||.||||::||.|.|:|:|.|:....|||.|||:
  Rat  1209 CSPLERFLGSVIMRRHLQRIIQ-QETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVT- 1271

  Fly  1299 LPPMPDKHPPPFQLSQDDLLVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLDL 1363
                |:.   ..|...|:|.|:|::|:||||.||::.|:|.:..:||..|..:|:|.|.||:|:|
  Rat  1272 ----PEN---AGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLEL 1329

  Fly  1364 KPELGGDQLKWTVQICLRMPPSAVPIVPSGNACVVMGRMKILFFLQITR---IPYGAVIGVGKDW 1425
            .|: ...||||.||.||.:||||.||.|.|...||: :.|:|||||:|:   :|.
  Rat  1330 FPD-QATQLKWNVQFCLTIPPSAPPIAPPGTPAVVL-KSKMLFFLQLTQKTSVPP---------- 1382

  Fly  1426 KDSPSLVLPIVYDIQTNVTQLA----ERTGQVISPTMTAASTLLRRFAEFN-AQQNQCTLFPAIT 1485
            ::..|:::||:||:.:..||.|    ::...|.:|.|  .|.:|:||||.| .:|.:||:|.|:.
  Rat  1383 QEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMM--VSNILKRFAEMNPPRQGECTIFAAVR 1445

  Fly  1486 DLLTNLQLAAEMPQPP 1501
            ||:.||.|      ||
  Rat  1446 DLMANLTL------PP 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED14	NP_728534.2	Med14	34..224	CDD:285801	107/198 (54%)
Med14	NP_001178656.1	Med14	57..244	CDD:285801	107/186 (58%)
Med14	NP_001178656.1	Jun	<1052..1147	CDD:281890	32/99 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342657
Domainoid	1	1.000	691	1.000	Domainoid score	I122
eggNOG	1	0.900	-	-		E1_KOG1875
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22082
Inparanoid	1	1.050	915	1.000	Inparanoid score	I342
OMA	1	1.010	-	-		QHG50140
OrthoDB	1	1.010	-	-		D1215335at2759
OrthoFinder	1	1.000	-	-		FOG0005245
OrthoInspector	1	1.000	-	-		oto97775
orthoMCL	1	0.900	-	-		OOG6_104094
Panther	1	1.100	-	-	LDO	PTHR12809
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770