Protein Alignment MED14 and rgr-1

DIOPT Version :10

• Sequence 1: NP_728534.2
• Gene: MED14 / 38073
• FlyBaseID: FBgn0035145
• Length: 1555
• Species: Drosophila melanogaster
• Sequence 2: NP_499067.3
• Gene: rgr-1 / 176320
• WormBaseID: WBGene00004343
• Length: 1388
• Species: Caenorhabditis elegans
• Alignment Length: 1694
• Identity: 389/1694 - (22%)
• Similarity: 610/1694 - (36%)
• Gaps: 528/1694 - (31%)

  Fly    59 LPRKT----DMERKVEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETA 119
            :.|||    :.|||:.:.::|..||..|.:|.|||||.....::|....|...||.|:..|::||
 Worm     1 MQRKTNDQGEQERKMSLVHFAHATRSQFLKLVALVKWIRISKRMDVCYSIDYLLDLQSQYFIDTA 65

  Fly   120 DMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKRQTLLRLNQV 184
            |.|..|:|..|..||||.:||..|::||..|||||:|:.|:|..:|...|||.|::....||||:
 Worm    66 DRLVAMTRGDLELARLPEYHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQKLVTSRLNQL 130

  Fly   185 IQHRL--VTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLVEDKETGD 247
            |:.||  ::..:.|.::|..|.||..|..|..||.:.:|::|:.....|.||:|.:||||.|.|.
 Worm   131 IESRLSRLSSGIPPNIKEIHINNGLATLLVPGEFEIKITLLGETEMTKWTLLNIKILVEDYELGM 195

  Fly   248 GKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNIT 312
            |..||||||:|.:|.::|:|:..:.|.:.|.::.||.||.||||:||:.||.||...||.| |||
 Worm   196 GLPLVHPLQLNQLHGVLQSRMNVSLNPIKEAFSFLHSFCVSLQLDVLFCQTSRLAAGRLRD-NIT 259

  Fly   313 VEEYVPGVK-LTVSYW-----------RDLKSELGYRLTVQSDPSEIGRPLAV---VHVPSLGAK 362
            :|:|.|..: |.|.||           ..:|.:..||:.:..||::....|.|   .|.|.||..
 Worm   260 IEKYDPKERVLVVGYWVKRSKSRRLTVGQVKCDAQYRVQIYEDPNDKLGGLKVRHFPHAPQLGRL 324

  Fly   363 ESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDCEFNLQGTPAILTVPVL 427
            :|.        :..||::||:..|..:|...||..|:...:|  .:...|..:.|    ::.|.|
 Worm   325 DSG--------AGMLSIDRLLSETYVVRCKERLMRLRRILEA--AEPRLEVKMTG----ISAPSL 375

  Fly   428 SPCL------RAEQIHITIDTHTGMFRCHVPKHLDCPIMEEMQDCLNGDRS---------KLPAL 477
            |..|      :.|.:.:::::..|...|:|  |:   :..|.:|.|...::         .:...
 Worm   376 SLALLPDTSSKDEMMTVSVNSFCGKVLCNV--HI---LSAEHEDVLAFGKALYSSQCSAHTIQMY 435

  Fly   478 LSELRFWITHRRCDKTLQHLP---ATATETLPFLVQ-----PDQEILQPGRHKIYVKLHRHPNIV 534
            |.:||..:...|..::::.||   ....|.|||..:     |.|.|:        ::..|..:..
 Worm   436 LRKLRVALVIERYRRSVKALPVREVQEAELLPFAKECLGDAPAQRII--------LQFLRSEDYY 492

  Fly   535 LVVQLK--EKTTMPNEMEYTFHLG----FVAYQKDELDVIDDSAMQLVSIVAQPHSDIPKCYTKL 593
            |:|...  ||..:...::....:|    |:..:.||:     :.|.:...:.|          ..
 Worm   493 LLVTFSPDEKAVVKTHIQLLEVVGDRAQFIQLEDDEM-----NGMHVKEAINQ----------GT 542

  Fly   594 MRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKI 658
            ||      |..:|  .|.:..|.|..:|                         ||..||..:::|
 Worm   543 MR------FSPSH--KTSLQEECSREQR-------------------------LAFAVATVEDRI 574

  Fly   659 PFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFATQQQQQQGAPAVAGENKPSGT 723
            .:|.||..|.|..|   |:.|..::..:         ||.........:
 Worm   575 TYMYLAAELMKKGI---GVDVRKDSAHV---------PGGLALHITDVK---------------- 611

  Fly   724 SGLPKIDSHVWDDLMRRVLSISIRSQTNKNSQVRIWVVEFVFYSTPL-----------QSSHPKE 777
            :.:|...|..::..:|..|.:.     |:|...  :..|..|.:.||           :...||:
 Worm   612 NVVPFEASEFFECCIRCCLRLD-----NRNRYT--FQFEMCFENIPLVRDVPHGLPHRRDGEPKD 669

  Fly   778 QGSRRTVYLTYEQANY----DFSKTVEDLLNDWSKIVYLYTLVYDFAEQLLNKRLSLCDMLVVKS 838
            :.|:...:|  ::.|:    ...|.||.:::...:.:|:|.:|:.|:........:.|:   :::
 Worm   670 RTSKDATWL--QELNHINQSSPEKLVELIIHRLMRYLYMYKVVHQFSLAYEKHFKNYCN---IEA 729

  Fly   839 YSYMNLLLGYGPKKEVSCNIYWSVQSHG-------FRLTFVGGMSAV-----------------N 879
            |::..|::.||..:::...:.::|:|..       |.|.|  |.|..                 |
 Worm   730 YTFHKLVVSYGDNRDMLMILAFNVKSQAPGSSEDFFFLNF--GQSMPHRQFNSTEIDWHQKPRWN 792

  Fly   880 GHSMMRDQLAQHLNQQHSITQIAQILHETYNPLSSIAKLPVLPF---------LGIPRPQVPV-L 934
            .||||...:...|.:.:.:......|.||..||.:|.....:.|         :| |....|. |
 Worm   793 PHSMMSQLMRDDLKETNDLVFTMHFLCETIRPLVAIGNFSRIRFQSQKSLSQLIG-PDVHFPFRL 856

  Fly   935 SFCVLAQSPCLIRLTYQAVYCLELRFRANRLVSIRDGASSR------FE--RNVVEEFTPIQGLK 991
            .:.:.|.....:|| .|....||::......:::||.:..|      |:  .|:..|.|.|..
 Worm   857 KYHLYALDQTTLRL-MQGNVILEIKLLEGCKIAVRDVSRYRPRCAGLFQLFSNIDSETTAIMN-- 918

  Fly   992 AFLSKYVDESAVYRGRASHEDDNPLSPMGMEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDS 1056
                   ||.|:
 Worm   919 -------DEIAI----------------------------------------------------- 923

  Fly  1057 GLRFPAPHTPPSSSNPHTPASPHPSAGAGGGSGPQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLN 1121
                      |.|.||.|             :||...                :|...|.|....
 Worm   924 ----------PQSDNPQT-------------AGPTMW----------------TPEQFMDSLDER 949

  Fly  1122 PQP-SPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPDHKSTGGGAGV 1185
            |:. .|.|..:..|   .:.|| |:...|.                        |.|.|.|
 Worm   950 PEEIDPRMAITSQP---ILMSH-DTIIKAC------------------------DFKDTEG---- 982

  Fly  1186 AGGTDRGGSRGTLNRPWAGAVPTLLTHEALETLCRPSPYPNKDINVPDMSPLERFLGCVYMRRQL 1250
                                   .:|....|.||..|......:.:..|||          |..|
 Worm   983 -----------------------RITCPLDEYLCSISYLQRALLTLERMSP----------RATL 1014

  Fly  1251 HRNIQSEET--LTALNSTEPGVVLFKV-----DGLQCQVVLNQMHMQTLHLKVSQLP-PMPDKHP 1307
            ::|..|..:  ...:...:|..:.|:.     ||      :|...|  :|.|:...| .|..|..
 Worm  1015 NKNSSSNLSCGFVTIIDAKPDFIRFRASQMNGDG------VNATSM--VHYKIYLCPVAMTLKIR 1071

  Fly  1308 PPFQ------LSQDDLLVIEQYFDTRVAAP---PYRPNSLHSICRLLNLPAQVLKDFVQIMRLDL 1363
            ..|:      .:.|:|..:..||: :|..|   .|...|...:.||.:..|  .:....:|.:.:
 Worm  1072 IEFEEGTNSAATADNLKTLTTYFE-KVVFPCGDEYALQSYICLTRLTSFEA--TQSIANLMNVQM 1133

  Fly  1364 K-PELGGDQLKWTVQICL--------RMPPSA--------------------------------- 1386
            : |...    |..||:.|        ::.|:.
 Worm  1134 EHPPTS----KCCVQLSLTYNNTSTKKLAPATKVDQPLQNIIFNVIVSQSRTSESFSVLRFIYRI 1194

  Fly  1387 ---VPIVPSGN------ACVVMGRMKI--------LFFLQITRIPYGAVIGVGKDW----KDSP- 1429
               ..:|||.|      |..|....|.        |..|.:.|...|       ||    :|.|
 Worm  1195 KENFVVVPSANEKNKQMADEVNAETKTSGGNPIWNLVRLVMDRFNSG-------DWNPGNRDEPI 1252

  Fly  1430 -SLVLPIVYDIQTNVTQLAERTGQVISPTMTAASTLLRRFAEFNAQQNQCTLFPAI---TDLLTN 1490
             |.|.|..|          ...|.|..|:..||.      ...:.||....|.|..   ...:..
 Worm  1253 ISSVAPPTY----------VNPGSVAGPSSVAAP------GSVSIQQPGSVLQPGSMMGPQSVNA 1301

  Fly  1491 LQLAA-EMPQPPPN------QSIGPPVGVGVGVGSSPNPMM-PMQQLPQQVGPQGPVGPG--GYP 1545
            ||... ..|...|.      .|:|.|..|| |.||....|| |....|..||..|.|.||  |||
 Worm  1302 LQYGMHRQPMGGPQSMQMNPSSVGQPGSVG-GPGSHQQHMMNPGSVGPGSVGGPGSVNPGSVGYP 1365

  Fly  1546 QMGP 1549
            |..|
 Worm  1366 QWNP 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED14	NP_728534.2	Med14	34..224	CDD:462543	68/170 (40%)
		PHA03247	<1027..1137	CDD:223021	14/110 (13%)
rgr-1	NP_499067.3	Med14	6..172	CDD:462543	65/165 (39%)
		Med15	<1235..>1388	CDD:312941	46/159 (29%)