DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED14 and rgr-1

DIOPT Version :9

Sequence 1:	NP_728534.2	Gene:	MED14 / 38073	FlyBaseID:	FBgn0035145	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	NP_499067.3	Gene:	rgr-1 / 176320	WormBaseID:	WBGene00004343	Length:	1388	Species:	Caenorhabditis elegans

Alignment Length:	1697	Identity:	388/1697 - (22%)
Similarity:	611/1697 - (36%)	Gaps:	534/1697 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LPRKT----DMERKVEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETA 119
            :.|||    :.|||:.:.::|..||..|.:|.|||||.....::|....|...||.|:..|::||
Worm     1 MQRKTNDQGEQERKMSLVHFAHATRSQFLKLVALVKWIRISKRMDVCYSIDYLLDLQSQYFIDTA 65

  Fly   120 DMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKRQTLLRLNQV 184
            |.|..|:|..|..||||.:||..|::||..|||||:|:.|:|..:|...|||.|::....||||:
Worm    66 DRLVAMTRGDLELARLPEYHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQKLVTSRLNQL 130

  Fly   185 IQHRL--VTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLVEDKETGD 247
            |:.||  ::..:.|.::|..|.||..|..|..||.:.:|::|:.....|.||:|.:||||.|.|.
Worm   131 IESRLSRLSSGIPPNIKEIHINNGLATLLVPGEFEIKITLLGETEMTKWTLLNIKILVEDYELGM 195

  Fly   248 GKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNIT 312
            |..||||||:|.:|.::|:|:..:.|.:.|.::.||.||.||||:||:.||.||...||.| |||
Worm   196 GLPLVHPLQLNQLHGVLQSRMNVSLNPIKEAFSFLHSFCVSLQLDVLFCQTSRLAAGRLRD-NIT 259

  Fly   313 VEEYVPGVK-LTVSYW-----------RDLKSELGYRLTVQSDPSEIGRPLAV---VHVPSLGAK 362
            :|:|.|..: |.|.||           ..:|.:..||:.:..||::....|.|   .|.|.||..
Worm   260 IEKYDPKERVLVVGYWVKRSKSRRLTVGQVKCDAQYRVQIYEDPNDKLGGLKVRHFPHAPQLGRL 324

  Fly   363 ESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDCEFNLQGTPAILTVPVL 427
            :|.        :..||::||:..|..:|...||..|:...:|  .:...|..:.|    ::.|.|
Worm   325 DSG--------AGMLSIDRLLSETYVVRCKERLMRLRRILEA--AEPRLEVKMTG----ISAPSL 375

  Fly   428 SPCL------RAEQIHITIDTHTGMFRCHVPKHLDCPIMEEMQDCLNGDRS---------KLPAL 477
            |..|      :.|.:.:::::..|...|:|  |:   :..|.:|.|...::         .:...
Worm   376 SLALLPDTSSKDEMMTVSVNSFCGKVLCNV--HI---LSAEHEDVLAFGKALYSSQCSAHTIQMY 435

  Fly   478 LSELRFWITHRRCDKTLQHLP---ATATETLPFLVQ-----PDQEILQPGRHKIYVKLHRHPNIV 534
            |.:||..:...|..::::.||   ....|.|||..:     |.|.|:        ::..|..:..
Worm   436 LRKLRVALVIERYRRSVKALPVREVQEAELLPFAKECLGDAPAQRII--------LQFLRSEDYY 492

  Fly   535 LVVQLK--EKTTMPNEMEYTFHLG----FVAYQKDELDVIDDSAMQLVSIVAQPHSDIPKCYTKL 593
            |:|...  ||..:...::....:|    |:..:.||:     :.|.:...:.|          ..
Worm   493 LLVTFSPDEKAVVKTHIQLLEVVGDRAQFIQLEDDEM-----NGMHVKEAINQ----------GT 542

  Fly   594 MRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKI 658
            ||      |..:|  .|.:..|.|..:|                         ||..||..:::|
Worm   543 MR------FSPSH--KTSLQEECSREQR-------------------------LAFAVATVEDRI 574

  Fly   659 PFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFATQQQQQQGAPAVAGENKPSGT 723
            .:|.||..|.|..|   |:.|..::..:         ||.........:
Worm   575 TYMYLAAELMKKGI---GVDVRKDSAHV---------PGGLALHITDVK---------------- 611

  Fly   724 SGLPKIDSHVWDDLMRRVLSISIRSQTNKNSQVRIWVVEFVFYSTPL-----------QSSHPKE 777
            :.:|...|..::..:|..|.:.     |:|...  :..|..|.:.||           :...||:
Worm   612 NVVPFEASEFFECCIRCCLRLD-----NRNRYT--FQFEMCFENIPLVRDVPHGLPHRRDGEPKD 669

  Fly   778 QGSRRTVYLTYEQANY----DFSKTVEDLLNDWSKIVYLYTLVYDFAEQLLNKRLSLCDMLVVKS 838
            :.|:...:|  ::.|:    ...|.||.:::...:.:|:|.:|:.|:........:.|:   :::
Worm   670 RTSKDATWL--QELNHINQSSPEKLVELIIHRLMRYLYMYKVVHQFSLAYEKHFKNYCN---IEA 729

  Fly   839 YSYMNLLLGYGPKKEVSCNIYWSVQSHG-------FRLTFVGGMSAV-----------------N 879
            |::..|::.||..:::...:.::|:|..       |.|.|  |.|..                 |
Worm   730 YTFHKLVVSYGDNRDMLMILAFNVKSQAPGSSEDFFFLNF--GQSMPHRQFNSTEIDWHQKPRWN 792

  Fly   880 GHSMMRDQLAQHLNQQHSITQIAQILHETYNPLSSIAKLPVLPF---------LGIPRPQVPV-L 934
            .||||...:...|.:.:.:......|.||..||.:|.....:.|         :| |....|. |
Worm   793 PHSMMSQLMRDDLKETNDLVFTMHFLCETIRPLVAIGNFSRIRFQSQKSLSQLIG-PDVHFPFRL 856

  Fly   935 SFCVLAQSPCLIRLTYQAVYCLELRFRANRLVSIRDGASSR------FE--RNVVEEFTPIQGLK 991
            .:.:.|.....:|| .|....||::......:::||.:..|      |:  .|:..|.|.|..
Worm   857 KYHLYALDQTTLRL-MQGNVILEIKLLEGCKIAVRDVSRYRPRCAGLFQLFSNIDSETTAIMN-- 918

  Fly   992 AFLSKYVDESAVYRGRASHEDDNPLSPMGMEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDS 1056
                   ||.|:
Worm   919 -------DEIAI----------------------------------------------------- 923

  Fly  1057 GLRFPAPHTPPSSSNPHTPASPHPSAGAGGGSGPQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLN 1121
                      |.|.||.|             :||...                :|...|.|....
Worm   924 ----------PQSDNPQT-------------AGPTMW----------------TPEQFMDSLDER 949

  Fly  1122 PQP-SPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPDHKSTGGGAGV 1185
            |:. .|.|..:..|   .:.|| |:...|.                        |.|.|.|
Worm   950 PEEIDPRMAITSQP---ILMSH-DTIIKAC------------------------DFKDTEG---- 982

  Fly  1186 AGGTDRGGSRGTLNRPWAGAVPTLLTHEALETLCRPSPYPNKDINVPDMSPLERFLGCVYMRRQL 1250
                                   .:|....|.||..|......:.:..|||          |..|
Worm   983 -----------------------RITCPLDEYLCSISYLQRALLTLERMSP----------RATL 1014

  Fly  1251 HRNIQSEET--LTALNSTEPGVVLFKV-----DGLQCQVVLNQMHMQTLHLKVSQLP-PMPDKHP 1307
            ::|..|..:  ...:...:|..:.|:.     ||      :|...|  :|.|:...| .|..|..
Worm  1015 NKNSSSNLSCGFVTIIDAKPDFIRFRASQMNGDG------VNATSM--VHYKIYLCPVAMTLKIR 1071

  Fly  1308 PPFQ------LSQDDLLVIEQYFDTRVAAP---PYRPNSLHSICRLLNLPAQVLKDFVQIMRLDL 1363
            ..|:      .:.|:|..:..||: :|..|   .|...|...:.||.:..|  .:....:|.:.:
Worm  1072 IEFEEGTNSAATADNLKTLTTYFE-KVVFPCGDEYALQSYICLTRLTSFEA--TQSIANLMNVQM 1133

  Fly  1364 K-PELGGDQLKWTVQICL--------RMPPSA--------------------------------- 1386
            : |...    |..||:.|        ::.|:.
Worm  1134 EHPPTS----KCCVQLSLTYNNTSTKKLAPATKVDQPLQNIIFNVIVSQSRTSESFSVLRFIYRI 1194

  Fly  1387 ---VPIVPSGN------ACVVMGRMKI--------LFFLQITRIPYGAVIGVGKDW----KDSP- 1429
               ..:|||.|      |..|....|.        |..|.:.|...|       ||    :|.|
Worm  1195 KENFVVVPSANEKNKQMADEVNAETKTSGGNPIWNLVRLVMDRFNSG-------DWNPGNRDEPI 1252

  Fly  1430 -SLVLPIVYDIQTNVTQLAERTGQVISPTMTAASTLLRRFAEFNAQQNQCTLFP-------AITD 1486
             |.|.|..|          ...|.|..|:..||.      ...:.||....|.|       ::..
Worm  1253 ISSVAPPTY----------VNPGSVAGPSSVAAP------GSVSIQQPGSVLQPGSMMGPQSVNA 1301

  Fly  1487 LLTNLQLAAEMPQPPPN------QSIGPPVGVGVGVGSSPNPMM-PMQQLPQQVGPQGPVGPG-- 1542
            |...:.   ..|...|.      .|:|.|..|| |.||....|| |....|..||..|.|.||
Worm  1302 LQYGMH---RQPMGGPQSMQMNPSSVGQPGSVG-GPGSHQQHMMNPGSVGPGSVGGPGSVNPGSV 1362

  Fly  1543 GYPQMGP 1549
            ||||..|
Worm  1363 GYPQWNP 1369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED14	NP_728534.2	Med14	34..224	CDD:285801	68/170 (40%)
rgr-1	NP_499067.3	Med14	6..172	CDD:285801	65/165 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160382
Domainoid	1	1.000	185	1.000	Domainoid score	I2025
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I1410
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1215335at2759
OrthoFinder	1	1.000	-	-		FOG0005245
OrthoInspector	1	1.000	-	-		oto17924
orthoMCL	1	0.900	-	-		OOG6_104094
Panther	1	1.100	-	-	LDO	PTHR12809
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R704
SonicParanoid	1	1.000	-	-		X5631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930