DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MED14 and med14

DIOPT Version :9

Sequence 1:	NP_728534.2	Gene:	MED14 / 38073	FlyBaseID:	FBgn0035145	Length:	1555	Species:	Drosophila melanogaster
Sequence 2:	XP_002932839.1	Gene:	med14 / 100379915	XenbaseID:	XB-GENE-982316	Length:	1442	Species:	Xenopus tropicalis

Alignment Length:	1560	Identity:	599/1560 - (38%)
Similarity:	857/1560 - (54%)	Gaps:	187/1560 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PLPLEQMPGVGGGGGGYLPAAQEGGPRINTMS------MSVLIDFIIQRTYHELTVLAELLPRKT 63
            |:.||....|..||...:|.....|..:.:.:      :|.||:|::||||.||.|||:|||||:
Frog     3 PVQLESSQLVVSGGPTSVPQPPPPGTVVASTAASHGYRLSTLIEFLLQRTYQELNVLADLLPRKS 67

  Fly    64 DMERKVEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRE 128
            |||||:||..:|:|||.||.||.|||||.|:..||:|.:.|.:|||:|.:|||:|||.||.::|:
Frog    68 DMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISNFLDQQTILFVDTADRLASLARD 132

  Fly   129 TLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKRQTLLRLNQVIQHRLVTGK 193
            .||.||||:|.||.|::|||||:|.|||||||::|:|.|.||..||:.||.:|||:::|||||..
Frog   133 ALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKNEKQTTLHQLNQILRHRLVTTD 197

  Fly   194 LLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLVEDKETGDGKSLVHPLQVN 258
            |.||:....:.||||.|.|:.||..:||||||:|.:|||||.:::||||||||||::|||.:|:|
Frog   198 LPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQIN 262

  Fly   259 YIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLT 323
            :||||:|:||..:...|.::|||||.||.|||||||::|||.|..||..| .:.|:.|:.|..||
Frog   263 FIHQLVQSRLFADDKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGD-LVQVDRYLAGKFLT 326

  Fly   324 VSYWRD--LKSELG----YRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERL 382
            :..|..  |..:.|    :::||:.|.::..:.|.:.|.|.|.|.:| ::.:||:|.:|||:|:|
Frog   327 LIVWNQQVLGRKTGTASVHKVTVKIDETDCSKTLQISHEPPLPACDS-KLMERAMRIDHLSIEKL 390

  Fly   383 IVHTVYIRSVSRLSDLKLEFQAFLKDVDCEFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMF 447
            ::.:|:.||..:|.:||...::| ...|..|.....|. |.:|:|.||.|:|.:|:.:|.|:|||
Frog   391 LIDSVHARSHQKLQELKTILKSF-NPSDNSFVETALPT-LVIPILEPCGRSECLHVFVDLHSGMF 453

  Fly   448 RCHVPKHLDCPIMEEMQDCLNGDRSKLPALLSELRFWITHRRCDKTLQHLPATATETLPFLVQPD 512
            :..: ...|...:::|:..:|.|..::...|.:|:||:..:||..:::|||...:|||.......
Frog   454 QLML-YGFDQTTLDDMEKSINDDMKRIIPWLQQLKFWLGQQRCRHSVKHLPTVCSETLHLTNYTT 517

  Fly   513 QEILQPGRHKIYVKLHRHPNIVLVVQLKEKTTMPNEMEYTFHLGFVAYQKDELDVIDDSAMQLVS 577
            ..|....||.:|:||.|.|...:||::.|....|.::||.:|...|::.:.|    |:....||.
Frog   518 HPISNLSRHSLYIKLTRLPQYYIVVEMFEVPGSPTQLEYAYHFLSVSHTEGE----DNPPTALVL 578

  Fly   578 IVAQPH-SDIP---KCYTKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDLLAPPAKQQK-T 637
            ...:|: .|:.   .|..::.                      :.:|||.:|:..:|.:|:.| |
Frog   579 QKFKPNVEDLALDGACRKQVK----------------------AGNKRKLSGEQGSPESKKPKRT 621

  Fly   638 IFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFA 702
            .....|...|||.|||||..:||:.|...||...|||.|:|:|.:..|..:::|.:|....|:..
Frog   622 GEICAFNKVLAHFVAMCDSNMPFIGLRMELSTMEIPHQGVQIEGDGFSHAIRLLRVPPCKGTSEE 686

  Fly   703 TQQQQQQGAPAVAGENKPSGTSGLPKIDSHVWDDLMRRVLSISIRSQTNKNSQVRIWVVEFVFYS 767
            ||:..:|.                              :|..:.|.|...|   |.||.|.||.:
Frog   687 TQKALEQS------------------------------LLDCTFRLQGRNN---RTWVAELVFAN 718

  Fly   768 TPLQSSHPKEQGSRRTVYLTYEQANYD---FSKTVEDLLNDWSKIVYLYTLVYDFAEQLLNKRLS 829
            .||.|...:|||..|.|.||||....:   ..|.||..||||:.|..||..|.:|:..|.:....
Frog   719 CPLNSIVSREQGPTRHVNLTYENPLSEPVGGRKVVEMFLNDWNSIARLYDCVLEFSRSLQDIPAH 783

  Fly   830 LCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTF--VGGMSAV-NGHSMMRDQLAQH 891
            |.....|:.|:|..|:|.|||.|..|.:|.|:.....|.::.  ||..|.. |.|:::..||.:.
Frog   784 LNMFCEVRVYNYRKLILCYGPTKGSSISIQWNSVHRKFHISLGTVGPNSGCSNCHNIILHQLQEM 848

  Fly   892 LNQQHSITQIAQILHETYNPLSSIAKLPVLPFLGI-PRPQVPVLSFCVLAQSPCLIRLTYQAVYC 955
            .|:..::.|:.|:|::|..||:||.|||.:|.||: .|.......|.:|.|||..|||.::.:||
Frog   849 FNKVPNVVQLLQVLYDTQAPLTSINKLPTVPMLGLTQRINTAYQCFSILPQSPTHIRLAFRNMYC 913

  Fly   956 LELRFRANRLVSIRDGASSRFERN-VVEEFTPIQGLKAFLSKYVDESAVYRGRASHEDDNPLSPM 1019
            :::..|:..:|:|||||.|.|:.: :||.|.|..|||.||:.:||.:...|.|:.:|||||.||:
Frog   914 IDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPI 978

  Fly  1020 G--MEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSA 1082
            |  |.|:.             .|.....|.:..|..:..|.....|.|.|.||. |...:|.||.
Frog   979 GGDMMDSL-------------LSQLQPQGQQTQQFTKQMGASGAYPLTSPPSSY-HNTVTPSPSM 1029

  Fly  1083 GAGGGSGPQGHGNFN------LTSP-PAPHMPHPSPSGL-MPSSPLNPQPSPHMVHSPGPNTLYM 1139
                 ...|..||..      |.:| ||...|.||||.| :...|.:...|||....|
Frog  1030 -----MHSQSPGNLQSSPSGVLRAPSPASFGPTPSPSSLGISMVPTSNFASPHGALDP------- 1082

  Fly  1140 QSHQDSPFTAMSPAN--NNWPGSPSMPRPSP---RPGQSPDHKSTGGGAGVAGGTDRGGS----- 1194
                .||:|.|||:.  .||||||.:..|||   .||.||.:.|.......|..:.|.|:
Frog  1083 ----SSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQSM 1143

  Fly  1195 -------RGTLNRPWAGAVPTLLTHEALETLCRPSPYPNKDINVPDM------SPLERFLGCVYM 1246
                   |....|.||.::||:|||.||..|..|||.|..   .|.:      ||||||||.|.|
Frog  1144 PTNMPPPRKLPQRSWAASIPTILTHSALHVLLLPSPTPGL---APALAGSYLCSPLERFLGSVNM 1205

  Fly  1247 RRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVVLNQMHMQTLHLKVSQLPPMPDKHPPPFQ 1311
            ||.|.|.|| :|||..:||.||||::||.|.|:|:|.||....|||.|||:     |:.   ..|
Frog  1206 RRHLQRIIQ-QETLQLINSNEPGVIMFKTDVLKCRVALNPTTNQTLQLKVT-----PEN---AGQ 1261

  Fly  1312 LSQDDLLVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLDLKPELGGDQLKWTV 1376
            ...::|.|:|::|:||||.||::.|:|.:..:||..||.:|:|.|.||:|:|.|: ...||||.|
Frog  1262 WKPEELQVLERFFETRVAGPPFKANTLIAFTKLLGAPAHILRDCVHIMKLELFPD-QTTQLKWNV 1325

  Fly  1377 QICLRMPPSAVPIVPSGNACVVMGRMKILFFLQITRIPYGAVIGVGKDWKDSPSLVLPIVYDIQT 1441
            |.||.:||||.||.|||...||: :.|:|||||:|:......        |:.|:::||:||:.:
Frog  1326 QFCLTIPPSAPPIAPSGTPAVVL-KSKMLFFLQLTQKTSAPT--------DAFSIIVPIIYDMAS 1381

  Fly  1442 NVTQLAE----RTGQVISPTMTAASTLLRRFAEFN-AQQNQCTLFPAITDLLTNLQLAAEMPQPP 1501
            ..||.||    :...|.:|  ...|.:|:||||.| .:..:||:|.|:.||:.||.|      ||
Frog  1382 GTTQQAEIPRQQNSSVTAP--LTVSNILKRFAEMNPPRPGECTIFAAVRDLMANLTL------PP 1438

Fly 1502 1501
Frog 1439 1438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED14	NP_728534.2	Med14	34..224	CDD:285801	110/195 (56%)
med14	XP_002932839.1	Med14	41..226	CDD:370023	108/184 (59%)
med14	XP_002932839.1	Herpes_BLLF1	<1007..>1186	CDD:282904	66/198 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	661	1.000	Domainoid score	I152
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22082
Inparanoid	1	1.050	887	1.000	Inparanoid score	I390
OMA	1	1.010	-	-		QHG50140
OrthoDB	1	1.010	-	-		D1215335at2759
OrthoFinder	1	1.000	-	-		FOG0005245
OrthoInspector	1	1.000	-	-		oto104459
Panther	1	1.100	-	-	LDO	PTHR12809
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R704
SonicParanoid	1	1.000	-	-		X5631
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110